著者

川島 栄吉

出版者

公益社団法人日本生物工学会

雑誌

醗酵工學雑誌 (ISSN:03675963)

巻号頁・発行日

vol.51, no.1, pp.41-46, 1973

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A respiration-less of Saccharomyces was cultivated by the batch or the continuous method in a culture stirred fermenter with glucose as the limiting substrate. In the batch cluture, initial conditions had an important effect upon the characteristics of the lag phase. The inoculation of more cells, or more active cells, shortened the period of the lag pahse. Monod's equation could not explain the above experimental results. And so, a mathematical model for the microbial growth process aws presented on the assumption that the growth rate is controlled in two steps and the lag phase is represented Eqs. 1 to 7. The parameters involved in the above equations were estimated by certain experimental data. The activity of cell accounted by the intermediate drived from glucose in cell. On the other hand, for the continuous culture, substituting in these equations with the mass balance ezuations, two steady states were obtained for each dilution rate; one was stable and the other was unstable. It was suggested that continuous culture may tend to wash out under certain initial conditions, in spite of a lower dilution rate.