著者

白 云哲 奥村 敏 常松 尚志 焦 其彬 小野 伸二 鈴木 さやか 黒谷 玲子 佐藤 元彦 南沢 享 石川 義弘

出版者

日本生理学会

雑誌

日本生理学会大会発表要旨集

巻号頁・発行日

vol.2008, pp.180-180, 2008

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Objective: Autonomic nervous activity is altered under microgravity. Cardiac response to autonomic regulation is mostly determined by &beta;-adrenergic receptors/cAMP signal that is regulated by adenylyl cyclase (AC). We thus examined the role of a major cardiac AC isoform, type 5 AC (AC5), in the autonomic regulation of the heart under microgravity induced by parabolic flights. Methods: We used transgenic mice with either disrupted (AC5KO) or overexpressed AC5 in the heart (AC5TG), and analyzed heart rate variability during parabolic flight. Results: The standard deviation of normal R-R intervals, a marker of total autonomic variability, was significantly greater under microgravity in AC5KO while no significant changes in WT and AC5TG. LF (low frequency)/HF (high frequency), a marker of sympathetic activity, became significantly lower under microgravity in WT and AC5TG while there was no such a decrease in AC5KO. Normalized HF, a marker of parasympathetic activity, became significantly greater in WT under microgravity, and became even greater in AC5TG, while no such increase in AC5KO. Conclusions: Putting together, changes in autonomic indexes in response to microgravity were augmented in AC5TG while attenuated in AC5KO, suggesting that AC5 plays a major role in determining the magnitude of cardiac responses to autonomic regulation under microgravity. <b>[J Physiol Sci. 2008;58 Suppl:S180]</b>

著者

野地 雅人 稲垣 浩 遠藤 聡 常松 尚志

出版者

日本脊髄外科学会

雑誌

脊髄外科 (ISSN:09146024)

巻号頁・発行日

vol.31, no.1, pp.80-86, 2017 (Released:2017-07-08)

参考文献数

25

被引用文献数

1

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Cervical angina is a pathological condition characterized by angina-like paroxysmal precordial pain caused by a lesion in the proximity of the cervical spine without cardiovascular abnormality. The symptom cannot be alleviated even with nitroglycerin administration. Although various reports have suggested possible causes, no report has identified the definite etiology of the disease. We report a rare case with frequent chest pain attacks, which completely disappeared after anterior cervical decompression and fusion and cervical calcified disc herniation. In addition, we compared the present case with previously reported cases.  The patient was a 78-year-old woman who complained of pain in the left chest and back area. Her symptoms worsened in August 2007. She was then hospitalized after undergoing medical examination in the emergency department, with the following results: ST segment depression (+), horizontal down-sloping V4-V6 on electrocardiography, and troponin (−). On the basis of these results, she was diagnosed as having unstable angina. Later, we conducted a cardiac catheter test and found 99-100% stenosis for #6 and 99% stenosis for #13 periphery. Percutaneous coronary intervention (PCI) for #6 was performed with a favorable collateral circulation. The patient did not have any symptoms during treadmill exercise and was discharged from the hospital. Although she repeatedly visited the emergency department every 2 or 3 months because of the pain in her left chest and back area, ischemia findings at the time of electrocardiography and blood test results were always negative. In March 2012, the symptom persisted even with PCI for #13. In June 2014, an acetylcholine prorocation test was conducted for suspected vasospastic angina, but the result was negative. As the patient occasionally had numbness and pain in both upper extremities, which worsened, she underwent a medical examination in our clinic in February 2015. Midline calcified hernia at C3/C4 and spur at C4/C5 were found on magnetic resonance imaging and computed tomographic myelography. Anterior decompression and fusion (C3/C4 and C4/C5) were conducted with a cylindrical cage in June 2015, and the postsurgical pain in the chest and back area completely resolved. A philological study showed that the affected segment often indicated symptoms associated with radiculopathy at the C6 or C7 myotome areas, but our case was considered a spinal segment disorder or sympathetic involvement.