著者

戸泉 文江 月川 健士 横山 祥子 といずみ ふみえ Fumie TOIZUMI

雑誌

九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare

巻号頁・発行日

no.18, pp.63-66, 2017-03-25

---

The distribution of benzyl caffeate (BC), phenethyl caffeate (PC) and cinnamyl caffeate (CC) inganglioside GM3 (GM3) monolayer as a model of a tumor membrane, and the effects of the caffeic acidesters on the GM3 membrane were observed by atomic force microscopy (AFM). BC and PC distributedin the GM3 monolayer formed holes in the GM3 matrix. The effects of BC and PC on the GM3 membranewere similar to those of known antitumor compounds, suggesting that BC and PC may possess antitumoractivitiy. The activity of CC seems to be weaker than that of BC and PC. The effects of caffeic acid esterson the GM3 membrane were different from those on the GD3 membranes.