著者

平田(中原) 久美子 鈴木 慎一郎 今井 徹 鷲巣 晋作 田村 めい 間 勝之 大塚 進 木村 高久

出版者

日本社会薬学会

雑誌

社会薬学 (ISSN:09110585)

巻号頁・発行日

vol.39, no.1, pp.19-22, 2020-06-10 (Released:2020-07-01)

参考文献数

16

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Distigmine has reversible and persistent cholinesterase (ChE) antagonism, and is used for the dysuria due to low activity bladders such as the neurogenic bladder dysfunction widely postoperatively, but fatal cases were reported by cholinergic syndrome. Therefore a dose was limited to 5mg only for adaptation of “the dysuria due to hypotonic bladder such as after surgery and the neurogenic bladder dysfunction” in March, 2010. In the current study, we examined a ministerial policy in the package insert revision using Japanese Adverse Drug Event Report database (JADER). Using a side effect report registered with JADER from January, 2004 to June, 2016, we calculated Reporting Odds Ratio (ROR) which was the index of the safe signal of the medical supplies adverse event and we compared number of reports and ROR of the cholinergic syndrome by the distigmine in approximately the measure in March, 2010 and evaluated it. The number of reports of the cholinergic syndrome by the distigmine was 138 cases before March 2010 and 65 cases after March 2010. After a measure, the number of reports decreased. The possibility that the package insert revision of the distigmine contributed to a decrease in cholinergic syndrome onset was suggested. Whereas monitoring careful sequentially needs the onset of the cholinergic syndrome in constant frequency to be found.

著者

早坂 正敏 青柳 京子 木村 高久 牧原 剛 牧村 瑞惠

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.27, no.4, pp.380-385, 2001-08-10 (Released:2011-03-04)

参考文献数

8

被引用文献数

2 2

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We have developed a system for the automatic checking of drug interactions when physicians order drugs using prescriptions. This checking is based on drug interaction data obtained form the package insert, which includes not only contraindicated combinations but also cautions. As these data can be printed out, it is easy to pass on such drug information to patients.The system also has a function whereby contraindications are always shown on the screen, whereas administration cautions and other information may be optionally omitted, or included where necessary. Therefore physicians can also order excess doses of some drugs or certain interacting drugs by prescribing them under special circumstances. These items of information are indicated with an asterisk in the prescription and are also provided to community pharmacies through legal prescriptions.The system displays the referred data on an order screen without any reduction in the response time of the host computer. The average response time was 3 s for up to a total of 17 different prescription drugs, and 4 s for more than 17. The response time from 10 : 00 a.m. to 2 : 00 p.m., when the frequency of outpatient prescription orders is the highest, was about the same as during other periods.These results suggest that this system is useful for checking of drug interactions on prescription in three hospitals affiliated with our medical college.