著者
石田 志朗 本池 慶 岡本 育子 山川 和宣 渡辺 智康 安藤 哲信 鈴江 朋子 岡野 善郎
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.40, no.5, pp.285-290, 2014-05-10 (Released:2015-05-10)
参考文献数
5

Amitiza® is available as an oval, soft gelatin capsule containing 24 μg of lubiprostone dissolved in a medium-chain triglyceride. Lubiprostone is a chloride channel activator indicated for the treatment of chronic idiopathic constipation in adults. Although Amitiza® capsules should be swallowed whole and not broken apart or chewed, the capsules have been administered by a simple suspension method to recipients unable to ingest food or drugs orally. The administration of Amitiza® capsule suspension through nasoenteric feeding tubes has not been investigated. Therefore, we evaluated whether the capsules are appropriate for administration through nasogastric tubes. The capsules disintegrated and dispersed after 10 min in 30 mL of hot water at 55°C. The suspension was transferred into a syringe or suspension bottle and passed through nasoenteric feeding tubes (8 Fr) without obstruction. Lubiprostone levels in each sample were determined by liquid chromatography/mass spectrometry. More than 93% of the lubiprostone was contained in suspension with flash solution through the feeding tubes administered through both the tubes. In conclusion, this study suggests that Amitiza® capsules can be administered to patients by a simple suspension method through nasoenteric feeding tubes.
著者
田坂 祐一 田中 亮裕 井門 敬子 田中 守 荒木 博陽
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.40, no.4, pp.208-214, 2014-04-10 (Released:2015-04-10)
参考文献数
7
被引用文献数
4 6

Pharmacists have increased the provision of pharmaceutical care services to patients. However, the financial benefit of various pharmaceutical interventions has not been well described. In this study, we estimated the original economic impact associated with pharmaceutical interventions by an evidenced-based approach.We classified pharmaceutical interventions into 12 items, which included preventions of serious adverse drug reactions (ADRs), and avoidance of drug interaction. The cost saving associated with preventions of serious ADRs was calculated as ¥2,140,000 per case based on the amount of costs that were paid by the Pharmaceuticals and Medical Devices Agency. Interventions to transvenous antimicrobial therapy were estimated to have a cost saving of ¥190,000 per case based on the literature in Japan. The rates of preventing serious ADRs related to chemotherapy orders, high-risk drugs and others were 5.21%, 3.91% and 2.6%, respectively, based on the literature in the United States. Using this rate, the values of intervention related to chemotherapy orders, high-risk drugs and others were ¥112,000, ¥84,000 and ¥56,000, respectively.The number of interventions was 209 per year, including 3 avoidances of serious ADRs. According to the number of interventions, we calculated that the total cost saving associated with pharmaceutical interventions was ¥22,816,000.This is the first study to estimate the economic impact associated with various pharmaceutical interventions of pharmacists in Japan. Evaluating the economic impact in relation to the pharmaceutical interventions is an important method for assessing the role of pharmacists.
著者
伊野 陽子 上野 杏莉 舘 知也 大坪 愛実 勝野 隼人 杉田 郁人 兼松 勇汰 吉田 阿希 野口 義紘 堺 千紘 井口 和弘 川上 ちひろ 藤崎 和彦 寺町 ひとみ
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.43, no.10, pp.533-551, 2017-10-10 (Released:2018-10-10)
参考文献数
6

In recent years, multi-occupational collaboration aiming at patient-centered care is required to provide high-quality medical care. However, there are few studies on collaboration between hospitals or clinics and community pharmacies. In this study, we conducted a questionnaire survey to clarify the present conditions and awareness of hospitals or clinics in Gifu City regarding collaboration with community pharmacies. The following activities with community pharmacies were examined in the survey: “I. Participation in regional care meetings,” “II. Case discussion conferences,” “III. Workshops/study conferences,” “IV. Community service,” “V. Sharing information through medical cooperation network,” “VI. Accompanying community pharmacists at home medical care” and future plans for these items. The percentage of non-implementation was 80% or more in Items I, IV and IV in the hospital and 80% or more in items other than III in the clinics. The percentage of respondents who were not planning to implement Item VI was over 70% in the hospital, and the percentage of respondents who were not planning to implement Items I, IV, VI was over 70% in the clinic. In the comparison between the hospital and the clinic, the proportion of current collaboration is significantly higher for II and III in the hospital. For collaboration in the future, the proportion of respondents who were planning to implement these items other than VI was significantly higher in the hospital. Many hospitals and clinics currently do not collaborate with community pharmacies. And more hospitals are considering collaboration with community pharmacies than clinics.
著者
木ノ下 智康 村田 史子 亀井 浩行 半谷 眞七子
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.41, no.12, pp.833-845, 2015-12-10 (Released:2016-12-10)
参考文献数
25

The study was conducted to qualitatively analyze the attitudes of pharmacists working in community pharmacies toward patients with dementia to examine the status of support provided for them and related problems. Semi-structured interviews with 15 pharmacists in Aichi Prefecture were conducted, and the results were analyzed using a grounded theory approach. The opinions of pharmacists were classified into “the status of consideration for dementia patients and responses to them at the pharmacy counter,” “problems related to the status of drug administration management for patients with dementia,” and “the status of support provided for dementia treatment.” Pharmacists must play various roles at the pharmacy counter and homes of patients: they should report “changes in dementia patients that they have identified” and conduct drug administration management for them. However, the pharmacists had difficulty due to their lack of knowledge and awareness of their roles, the current system of pharmacies only focusing on drug prescription, differences in problems attributed to specific symptoms unique to dementia and the specificity of individual cases, and a lack of understanding of other people and collaboration with them. To help pharmacists provide quality services for dementia patients, it is necessary to encourage them to: undergo training to improve their awareness, learn to provide services with emphasis on the establishment of relationships between patients and their families, and closely collaborate with other pharmacists and different healthcare professionals, as well as enhance the functions of pharmacies as bases for consultation.
著者
五郎丸 剛 佐々木 智也 藤井 利加 一木 孝治 高橋 浩二郎 福長 将仁 江藤 精二
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.34, no.1, pp.59-63, 2008 (Released:2009-09-04)
参考文献数
16
被引用文献数
1 1

Antibiotic-resistant lactic acid bacteria (RLAB) and clostridium butyricum (CB) preparations are often used to improve symptoms resulting from antibiotic-induced changes in intestinal flora.However,though the resistance of these preparations to fluoroquinolones (FQs) has not been sufficiently studied,they are sometimes prescribed in combination with FQs under off-label use.The reason for this is thought to be that all RLAB and CB preparations are considered to be resistant to all antibiotic agents.In this study,we determined the minimal inhibitory concentrations of FQs with respect to strains isolated from five RLAB and one CB preparation using the microdilution method.Furthermore,the susceptibility to FQs of the strains isolated from the RLAB preparations was compared with that of strains isolated from conventional lactic acid preparations.The strains from most of the RLAB preparations and that from the CB preparation were found to be susceptible to FQs.There was also no difference in bacterial resistance between the RLAB and conventional lactic acid preparations.The concurrent use of RLAB and FQs under off-label use should therefore be avoided.
著者
小澤 秀介 小林 愛子 高津 亜希子 神田 博仁 山折 大 塩沢 丹里 大森 栄
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.42, no.3, pp.202-208, 2016-03-10 (Released:2017-03-16)
参考文献数
20

We report the case of a 35-year-old pregnant woman treated with the calcium channel blocker, nifedipine, for maintenance tocolysis. She was hospitalized due to preterm labor at 21 weeks of gestation by her previous physician. A rash appeared following ritodrine hydrochloride administration for maintenance tocolysis. After changing to magnesium sulfate, a rash appeared again. As these rashes were suspected to have been induced by ritodrine hydrochloride and magnesium sulfate independently, consecutive treatment with these drugs was difficult. Therefore, she was transferred to our hospital for follow-up. At 28 weeks 6 days of gestation, treatment with nifedipine for maintenance tocolysis was started after receiving written informed consent, and the medication was approved by the institutional review board of our hospital. The attending pharmacist considered fetal/neonatal adverse effects of nifedipine, such as teratogenicity, fetotoxicity, and neonatal complications, as well as maternal side effects, such as headache, constipation, and excessive blood pressure drop. The pharmacist provided drug information about nifedipine to the attending physicians and nurses, and gave medication counseling to the patient. Following oral administration of 80 mg of nifedipine daily (20 mg every 6 hours), headache and constipation were evident but gradually improved. Neither excessive blood pressure drop nor exacerbated uterine contraction was observed throughout the period of nifedipine treatment. This medication was finished at 34 weeks 5 days of gestation and the patient was discharged at 36 weeks 2 days of gestation. She delivered a baby at 40 weeks 3 days of gestation.
著者
渡邊 美智留 三田 恭平 中村 春世 田中 恒明 三原 潔 小野 秀樹
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.40, no.12, pp.726-733, 2014-12-10 (Released:2015-12-10)
参考文献数
9

Pregabalin, a useful drug for neuropathic pain, has a high incidence of dizziness and somnolence as side effects. In the present study, the incidence of both side effects and the risk factors were retrospectively investigated in hospitalized patients who were administered pregabalin after their admission. In 65 patients (median 68 years old), 34 cancer patients and 18 opioid users were included. Items studied were cancer/non-cancer, opioid user/non-user, fall/nonfall, age, sex, weight, daily dose of opioids, the number of the drugs that may cause dizziness and somnolence, daily dose of pregabalin, and the ratio of creatinine clearance to daily dose of pregabalin. Fourteen (21.5%) and 21 (23.3%) patients developed dizziness and somnolence, respectively, and 4 (6.1%) patients developed fall. In the case of opioid combination, 7 (38.9%) and 10 (55.6%) patients developed dizziness and somnolence, respectively. A logistic-regression analysis showed that opioid use is a significant augmenting risk factor for dizziness (P = 0.026) and somnolence (P = 0.016) of pregabalin. The ratios of daily dose of pregabalin to creatinine clearance did not show any relation to the incidence of dizziness and somnolence; both side effects were observed in some patients whose renal functions were normal. It is suggested that attention is necessary to the incidence of dizziness and somnolence regardless of renal function, and that particular attention is required when opioids, which have similar side effects, are combined with pregabalin.
著者
今井 達男 岡部 信彦
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.41, no.12, pp.907-915, 2015-12-10 (Released:2016-12-10)
参考文献数
23

The infectiousness of diseases such as: the measles, rubella, the mumps, and the chicken pox is quite strong. When people lack antibodies to these diseases, the chance for infection increases. On a university campus, a person without such antibodies can help spread such diseases. However, as vaccines are available for these diseases and people are vaccinated, the chance for infection and the spreading of these diseases will diminish. At our university, Tokyo University of Pharmacy and Life Sciences, at the start of the recent academic year, an antibody survey was taken of 2,647 students to see which students had lower levels of antibodies to help fight the spread of the aforementioned diseases. Our findings showed antibody-positive rates of 49.0% for the measles, 70.8% for rubella, 75.7% for the mumps, and 92.4% for the chicken pox. With the rate for the chicken pox being the only one meeting an acceptable standard (Fine) in terms of community immunity. On the other hand, although the vaccination rates for the measles and rubella were high, they did not meet an acceptable standard for community immunity (Fine). When the community immunity level is low, the risk of infection is increased and this could lead to an outbreak on campus and affect more than just individuals. In the future, we will encourage students to be fully vaccinated before entering school or soon after doing so in order to protect against such an outbreak from occurring.
著者
中村 一仁 浦野 公彦 田中 万祐子 西口 加那子 堺 陽子 片野 貴大 鍋倉 智裕 山村 恵子 國正 淳一
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.40, no.9, pp.522-529, 2014-09-10 (Released:2015-09-10)
参考文献数
10
被引用文献数
5 4

This study examined the reduction in medical expenses achieved by pharmaceutical inquiries at a community pharmacy. The total number of inquiries was 1,053 out of a total of 29,875 prescriptions filled at one community pharmacy (incidence: 3.5%). Pharmaceutical inquiries regarding the elimination of prescribed medicines were classified into two categories: leftover (incidence: 0.76%) and those regarding duplicate prescriptions filled by other institutions or drug interactions (incidence: 0.18%). The doctors accordingly reduced the number of medicines after these inquiries, which led to a reduction in dispensing and medical fees. The reduction in patient medical expenses per prescription from leftover medicines was 1,425 yen (median) for children (under 14 years), 390 yen for adults (15-64 years), and 1,165 yen for elderly patients (over 65 years). The reduction in patient medical expenses per prescription from eliminating duplicate prescriptions was 955 yen for children, 250 yen for adults, and 360 yen for the elderly. The reduction in patient medical expenses from leftover medicines was statistically higher compared with that from duplicate prescriptions for elderly patients (P < 0.01). This difference was because of long-term drug prescriptions for cardiovascular diseases and diseases of the digestive and central nervous systems. Our findings show that community pharmacists can effectively reduce patient medical expenses and increase patient safety by responding to pharmaceutical inquiries and collecting leftover medications.
著者
面谷 幸子 名徳 倫明 山城 美樹 長谷川 渚彩 大橋 甲三郎 長井 克仁 西井 諭司 初田 泰敏 小川 雅史
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.42, no.1, pp.31-39, 2016-01-10 (Released:2017-01-10)
参考文献数
10

Workshops on the use of adrenaline auto-injection (EPIPEN), reconsideration of training programs on food allergies, and an approach to increase risk awareness of food allergies are required. We investigated the current state of education of school teachers and school pharmacists in Tondabayashi City.A total of 120 school teachers and 14 school pharmacists participated in our questionnaire. More than 90% of teachers had experience with children with allergies, and more than 95% of teachers were aware of anaphylaxis. Although most teachers were familiar with EPIPEN, they did not have detailed knowledge and were not confident in using it in an emergency. School teachers who attended EPIPEN workshops had a higher degree of confidence in using EPIPEN in an emergency than school teachers who do not attended the workshops. Attending workshops will increase the self-confidence of teachers in using EPIPEN in an emergency. The survey results indicate that it is important for school pharmacists to hold regular workshops on EPIPEN, including practical training, to develop the EPINEN skills of school teachers and enlighten them on the subject.
著者
丹羽 隆 篠田 康孝 鈴木 昭夫 大森 智史 太田 浩敏 深尾 亜由美 安田 満 北市 清幸 松浦 克彦 杉山 正 村上 啓雄 伊藤 善規
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.38, no.5, pp.273-281, 2012-05-10 (Released:2013-05-10)
参考文献数
38
被引用文献数
1 5

Antimicrobial resistance in hospitals is increasingly becoming a major problem worldwide, thus appropriate use of antimicrobial agents should be promoted. Since August 2009, our hospital has established a review system for checking prescriptions in all patients receiving antimicrobial injections according to the intervention and feedback of antimicrobial stewardship (AMS) guideline. The antimicrobial use density (AUD), duration of administration, length of hospital stay, and antimicrobial resistance in a year were compared before and after starting the intervention into AMS. Suggestions made by members of the infection control team (ICT) to the prescribers were for the major part the choice and dose elevation of antimicrobials. Most of the proposals (91%) were accepted by the prescribers. Although AUD was not changed after AMS intervention, the proportion of prolonged antimicrobial use (over 2 weeks) was significantly reduced from 5.2% to 4.1% (p=0.007), which led to the saving of costs for antibiotics (4.48 million yen/ year). The incidence of MRSA tended to decrease after AMS intervention (p=0.074). The median length of hospital stay was ultimately shortened by 1.0 day (p=0.0005), which led to an estimated saving of medical costs by 520 million yen/year. We consider that our intervention profoundly affects this cost saving. These findings suggest that the extensive intervention into AMS is effective in reducing the frequency of inappropriate use of antimicrobials, suppressing the occurrence of antimicrobial resistance, and saving medical expenses.
著者
脇 由香里 吉見 陽 千﨑 康司 宮田 はるみ 伊東 亜紀雄 相馬 孝博 上田 裕一 毛利 彰宏 山田 清文 尾崎 紀夫 野田 幸裕
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.37, no.8, pp.475-480, 2011 (Released:2012-08-30)
参考文献数
16
被引用文献数
1 1

Falls and fall-related injuries among inpatients are one of the most important concerns in medical safety management and sometimes cause a significant decrease in activities of daily living (ADL). It has been suggested that the adverse reactions of psychotropic drugs related to their sedative-hypnotic, cognitive deficit producing and muscle reaction-related effects are closely associated with falls.In this study, we examined a relationship between the risk of falls and psychotropic drugs based on prescriptions in fall incident reports at Nagoya University Hospital in a 12-month period beginning in April 1, 2005. In July 2006, we conducted an educational intervention involving instructing health care staff on the optimal use of psychotropics. After doing this, we examined prescriptions in fall incident reports over a 12-month period beginning in April 1, 2006. The results showed a decrease in fall incidence due to long-acting drugs in 2006 as compared with 2005 and this indicated that, among psychotropics, sedativehypnotic-anxiolytics were one of the highest risk factors for falls. These results suggest that an educational intervention can be an effective means of reducing the number of falls and fall-related injuries among inpatients.
著者
大野 能之
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.39, no.5, pp.257-270, 2013-05-10 (Released:2014-05-10)
参考文献数
33

Renal dysfunction and drug-drug interactions (DDIs) can affect the clearance of various drugs from the body; however, these effects are difficult to sufficiently evaluate in clinical studies. This article outlines our recent approaches to improve the method of evaluating and providing the drug information on the effects of renal dysfunction and DDIs. These approaches aim to optimize the drug regimens of patients with renal dysfunction and to improve the management of DDIs. The renal excretion ratio (RR) is required to predict alterations in drug clearance in patients with renal dysfunction. However, the estimation of RR requires pharmacokinetic information that is not always provided in the Japanese drug package inserts or interview forms.A systematic approach to predict changes in drug clearance due to DDIs of the cytochrome p450 (CYP) is described. Uniquely, this method uses a small number of parameters, which are only obtained by in vivo DDI studies, i.e., the contribution ratio of CYPs to oral clearance of substrates (CR), the inhibition ratio of inhibitors (IR) or the increase in clearance by induction (IC). Changes in oral clearance for any combination of drugs can be predicted once these parameters have been calculated for each drug. These predictions were used to construct a pharmacokinetic interaction significance classification system (PISCS) to evaluate the clinical risk of DDIs in daily therapy.
著者
飯原 なおみ 吉田 知司 岡田 岳人 中妻 章 桐野 豊
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.40, no.2, pp.67-77, 2014-02-10 (Released:2015-02-10)
参考文献数
12
被引用文献数
2 1

There is no report to date regarding the usage status of medications with driving with prohibitions or cautions in Japan. Upon sampling the national health insurance claims database (covering 1% of outpatients), we surveyed the prescriptions and use of medications in outpatient settings for patients aged 25 years and older, with the goal of encouraging the proper use of medications.We analyzed the ratio of outpatients who were administered medications with prohibitions or cautions on driving to total outpatients who were administered medications (prescribed and/or provided to them at the time of examination). We also examined daily dosages and deviations from specified dose-limits for their prescribed oral medications.Of 566,968 outpatients aged 25 years and older who were administered medications, 413,940 (73%) outpatients were given the medications with cautions or prohibitions on driving and 243,405 (43%) outpatients were administered the medications with a prohibition on driving.Daily dosages of many medications were reduced with the increase in age of the patient. The degree of dosage reduction varied widely, with some medications whose dosages were hardly adjusted with age. With some medications with dose-limitations or contraindications for the elderly, prescriptions were found with dosages that often exceeded the recommended limits.We conclude that outpatients given medications and/or prescriptions must exercise appropriate caution when driving and that the dosage of these medications should be adjusted especially in the elderly.
著者
後藤 佐昌子 八軒 浩子 高田 充隆
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.37, no.1, pp.21-30, 2011 (Released:2012-04-27)
参考文献数
17
被引用文献数
2

To quantitatively investigate the history of medical pharmacy research in Japan,we analyzed the titles of articles in theJapanese Journal of Pharmaceutical Health Care and Sciences and the Japanese Journal of Hospital Pharmacy,the principalmedical pharmacy journals in Japan,by text-mining.All article titles (2884 articles) between 1975 and 2009 were collectedfrom article databases,and the text of titles was analyzed using the KH Coder,free software for quantitative textanalysis of the Japanese language.This software produces basic information on text data such as the rate of occurrence ofcertain words.Nine research categories were identified through multivariate analysis of frequently appearing words.Also,coding rules were created to assign article titles to these research categories,and the categorization results were analyzed quantitatively.Pharmaceutical investigation was the principal category in the 1970 s and 80 s,with the quality evaluation of drugs asthe major area of research.Articles assigned to this category accounted for 41.4% of all articles published during the period1980-1984.Articles assigned to the drug therapy category began to gradually increase in the 1990 s,and since 2000,drugtherapy has been the major area of medical pharmacy research in Japan.In addition,there has been an increase in investigationsassociated with the education of pharmacists and pharmacy students in recent yearsOur findings suggest that there has been a shift in the dominant research area of medical pharmacy in Japan from qualityevaluation of drugs to patient care.
著者
植沢 芳広 内田 明宏 小山 茜 宇田川 三男 武田 直子 富澤 崇
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.40, no.4, pp.215-221, 2014-04-10 (Released:2015-04-10)
参考文献数
7
被引用文献数
1 1

Patients' waiting times in a community pharmacy closely correlate with prescription dispensing times. Therefore, to decrease patients' stress and present an index in dispensing operations, various factors affecting prescription dispensing were analyzed, and a time-prediction model was constructed. The time from when a prescription was accepted (ie, handed in by a patient) to its checking, as well as time-factors affecting dispensing and checking, were measured at Kitayurakucho Pharmacy. Additional aspects were taken into account, such as: acceptance time, whether questions needed to be asked of the prescribing physician, medicine-counting, number of pharmacists present, and number of patients in the waiting area. Thereafter, a statistical prediction model for waiting time was constructed. It was found that drug counting and congestion level significantly related to waiting time. A multivariate regression model with two such parameters indicated a highly accurate prediction level. It is expected that prediction of the waiting time with this model will be useful for alleviation of the patients' stress.
著者
松岡 紗代 三木 晶子 佐藤 宏樹 堀 里子 澤田 康文
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.38, no.9, pp.592-598, 2012-09-10 (Released:2013-09-12)
参考文献数
9
被引用文献数
5 4

Non-steroidal anti-inflammatory drug (NSAID) patches tend to be prescribed in larger amounts than are actually used and surplus patches are often kept at patients' homes. Improper use of these patches without the advice of healthcare professionals might result in serious adverse effects. This study investigated patients' opinions and requests regarding the prescribed amount of NSAID patches, and their intended use of surplus patches. A web-based questionnaire survey was conducted on patients who had been prescribed NSAID patches within the previous year. There were 618 respondents. Patients who described the amount of patches prescribed as “just the amount needed" and “quite or somewhat excessive" amounted to 41%and 40%of the respondents, respectively. Forty-three-percent of respondents had at some time requested a larger prescribed amount or an additional prescription. Sixty-four-percent of them received the prescription they requested. Also, 61 % of respondents had unused NSAID patches at their homes, and many of them intended to use these patches as they felt necessary. Patients who believed that NSAID patches do not induce side effects amounted to 24%, while 54%of patients had at some time suffered symptoms possibly due to systemic or local side effects of NSAID patches. Considering the above results, healthcare professionals should provide suitable and sufficient information about NSAIDs patches to patients, and take steps to minimize the numbers of unused patches remaining at the patients' homes in order to avoid improper use of NSAID patches and to reduce medication costs.
著者
小森 浩二 山崎 裕己 古前 竜平 玉登 まき 福田 洋 板橋 司 菊田 真穂 高田 雅弘 宮﨑 珠美 中野 祥子 三田村 しのぶ 首藤 誠 山本 淑子 塙 由美子
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.40, no.3, pp.186-192, 2014-03-10 (Released:2015-03-10)
参考文献数
12

Loxoprofen (Loxonin®) is a widely administered non-steroidal anti-inflammatory drug (NSAID) in Japan, with annual sales exceeding 50 billion Japanese yen. Although it is a very versatile drug and is often administered to breastfeeding women, the information available regarding its mammary gland transfer is inadequate.Therefore, in this study, we analyzed loxoprofen levels in the blood and milk of four breastfeeding women who received the drug for pain relief. These women visited the Obstetrics and Gynecology Department of Hanwa Sumiyoshi General Hospital for consultation or a cesarean section.One tablet of Loxonin® (loxoprofen 60 mg) was orally administered to each of the four women, and blood and milk samples were collected 0, 30, 90, 150 and 330 min after drug administration. Twenty microliters of ethanol was added to the blood and milk samples (10 μL), and the mixture was centrifuged at 12000 g for 15 min. The supernatant was analyzed by high-performance liquid chromatography (HPLC).Loxoprofen levels in blood peaked 90 min after its oral administration in all four patients, with the highest level being 4.5 μg/mL in patient II, whereas loxoprofen level in milk was below the detection limit (0.1 μg/mL) at all time points. Taken together, the data suggest low mammary gland transfer of loxoprofen, and thereby a low lactation risk.
著者
向井 淳治 徳山 絵生 木本 美香 宮武 望 小野原 未由来 本荘 愛美 濱田 藍子 髙橋 直継
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.40, no.4, pp.245-251, 2014-04-10 (Released:2015-04-10)
参考文献数
7
被引用文献数
4 4

Izumi Municipal Hospital conducts practical hospital training for pharmacy students by dividing the training schedule into four periods according to the content of the programs offered. When we read the training diaries drawn up during that period, we found no uniformity in the description methods used by different students, and found evidence of quantitative and qualitative differences. This may indicate that there are problems with the instruction method being used. We therefore investigated the diaries' written content in order to identify the cause of differences between the descriptions therein and problems with the instruction method.A text mining technique was employed to analyze nouns used in the training diaries. Regarding the pattern of the appearance of nouns, similarities were observed among students in passive training programs, but differences were found between students in active training programs.It was suggested that the stronger the connection was between nouns appearing in the diaries within each of the scheduled training periods, the more the students associated these nouns with each other to understand the material presented during training.In light of these findings, it is suggested that (1) it is important for students to understand the material they have learned during training and make connections with each other and (2) it is necessary for instructing pharmacists to provide instructions while confirming and assessing students' training diaries. The evaluation of training diaries using the data mining technique was useful for these purposes.