- 著者
- 杉江 亮祐 百武 徹
- 出版者
- 一般社団法人 日本機械学会
- 雑誌
- バイオエンジニアリング講演会講演論文集 2016.28 (ISSN:24242829)
- 巻号頁・発行日
- pp._1C43-1_-_1C43-5_, 2016-01-09 (Released:2017-06-19)
Infertility is often cited as one of the causes of the declining birthrate, which has a social problem in recent years. Roughly 10% of couples have infertility problems, and almost 50% of all cases of infertility are associated with a lack of sperm or sperm abnormalities. Therefore, motile sperm are required to increase the probability of fertilization. We previously observed of flagellar motion of bovine sperm and clarified that ambient fluid viscosity and non-Newtonian properties affected its shape and motion. However, the detail mechanics of the effect of surrounding fluid properties on the sperm motion is still unclear. Therefore, we simulated the sperm motion in various viscosity and non-Newtonian fluid to reveal the effect of the surrounding environments on the sperm motility. The simulation results indicated the decrease in the sperm velocity when the viscosity increased, because the increase in the viscosity lead to increase in the resistance of the ambient fluid. Additionally, the increase in the viscosity brought about the increase in sperm motility. We compared the present results with previous experimental data for the sperm velocity, and estimated the sperm motility for each viscosity. Consequently, we obtained the relationship of viscosity coefficient and sperm motility. These results will provide the useful information to estimate the sperm motility for various fluid properties.
1 0 0 0 OA 脊椎疾患と鑑別を要する筋骨格系運動器疾患について考える
- 著者
- 小畑 仁司 荻田 誠司 川上 真樹子 二村 元 杉江 亮
- 出版者
- 一般社団法人 日本脳卒中の外科学会
- 雑誌
- 脳卒中の外科 (ISSN:09145508)
- 巻号頁・発行日
- vol.45, no.6, pp.445-450, 2017 (Released:2017-12-22)
- 参考文献数
- 23
- 被引用文献数
- 2 1
Fever in subarachnoid hemorrhage (SAH) is associated with vasospasm and poor outcome. To mitigate early brain damage in SAH, we have been treating World Federation of Neurological Surgeons (WFNS) Grade 5 patients with rapid induction of therapeutic hypothermia (TH) initiated immediately following onset of SAH and continued for approximately 7 days. Management after rewarming has been problematic. Rebound fever, especially during the period of post-SAH vasospasm, may increase the risk of cerebral infarction. We prospectively studied the feasibility and safety of endovascular cooling for maintaining prophylactic normothermia following initial TH in patients with severe SAH.TH (core body temperature 34.0°C) using surface cooling was initiated immediately after a diagnosis of WFNS Grade 5 SAH was made. All ruptured aneurysms were surgically clipped as soon as possible within 6 hours after arrival. At approximately postoperative day 7, after rewarming to 36°C, an endo- vascular catheter with 2 cooling balloons (Cool Line® Catheter, Asahi Kasei ZOLL Medical Corp., Tokyo, Japan) was inserted into the left internal jugular vein and connected to the Thermogard XP® Temperature Management System (Asahi Kasei ZOLL Medical Corp.) for the following 7 days. Temperature recordings in 11 SAH patients immediately before the period of endovascular cooling served as the control.Eleven patients (6 women; mean age of 63.8 ± 6.4 years [range, 50-73 years]) were enrolled in the study. Endovascular cooling was initiated at 7.9 ± 1.4 days (range, 6-11 days) after admission and continued for 6.7 ± 0.9 days (range 4-7 days). Unfavorable outcomes were associated with minimal shivering and good temperature control, whereas favorable outcomes were associated with vigorous shivering and increased temperature. Nine patients manifested shivering with increased temperature and were treated with acetaminophen, dexmedetomidine, and/or propofol. During the study period, two patients developed fevers above 38°C, and 8 of 11 patients without endovascular cooling developed fevers (p=0.03, two-tailed Fisher's exact test). There was no evidence of cerebral infarction related to vasospasm during endovascular cooling, and no catheter-related sepsis or thromboembolic events. In one patient, fasudil hydrochloride was administered intra-arterially for angiographic vasospasm, resulting in no cerebral infarction. In another patient, intensive treatment was withdrawn because of massive brain swelling; however, slight but extensive early ischemic change was retrospectively confirmed on computed tomography prior to endovascular cooling. Vasospasm-related cerebral infarction occurred in one patient 2 days after removal of the cooling catheter. In one patient, fatal bacterial meningitis related to spinal drainage occurred on Day 29. Three-month outcomes showed good recovery in 2, moderate disability in 4, severe disability in 2, vegetative state in 1, and death in 2. Amelioration of fever burden during the first 14 days after onset of SAH was safe and feasible with combined surface and endovascular cooling in patients with WFNS Grade 5 SAH.
