著者

桜井 淑男 小幡 徹 堀口 徹 鳥海 和弘 鹿瀬 陽一 谷藤 泰正

出版者

The Japanese Society of Intensive Care Medicine

雑誌

日本集中治療医学会雑誌 (ISSN:13407988)

巻号頁・発行日

vol.11, no.2, pp.143-144, 2004-04-01 (Released:2009-03-27)

参考文献数

6

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We have developed a high sensitive method of measuring the serum endocannabinoids (anandamide, ABA and 2-arachidonyl-glycerol, 2-AG) by gas chromatography and mass spectrometry (GC/MS) with isotope dilution. We measured the serum endocannabinoids in 5 esophageal and 5 lung cancer patients perioperatively with GC/MS to clarify the relationship between perioperative inflammation and endocannabinoids. It was demonstrated that ABA didn' t significantly change perioperatively, although the pre and postoperative 2-AG concentrations in the cancer patients were significantly higher than the control value (P<0.05) and that AEA did not change perioperatively in significant manner. Therefore, 2-AG may play a pivotal role in perioperative inflammation.