- 著者
-
小山 和弘
小笠原 伸子
青野 美弘
梶原 博視
関口 久紀
- 出版者
- 日本医療薬学会
- 雑誌
- 医療薬学 = Japanese journal of pharmaceutical health care and sciences (ISSN:1346342X)
- 巻号頁・発行日
- vol.27, no.1, pp.24-28, 2001-02-10
- 被引用文献数
-
2
We investigated the relationship between the serum vancomycin concentration and the initial dosage regimen. Furthermore, we evaluated the dose and dosage interval for the therapeutic level (trough< 10μg/mL, peak 25-40μg/mL) and the toxic level (trough>15μg/mL).<BR>The percentage of the concentration within the therapeutic level was 0% and the percentage over the toxic level was 71% regarding a vancomycin dose of 500mg every 6 hours. The percentage of the concentration within the therapeutic level was 0% and the percentage over a toxic level was 23% regarding a dose of 500 mg every 12 hours. The percentage of the concentration within therapeutic level was 0% and the percentage over the toxic level was 33% regarding a dose of 1, 000mg every 12 hours. The percentage of the concentration within the therapeutic level was 21% and the percentage over the toxic level was 11% regarding a dose of 1, 000mg every 24 hours. The percentage of the concentration within the therapeutic level was 33% and the percentage over the toxic level was 10% regarding a dose of 1, 500mg every 24 hours. As a result, a dose of 1, 500mg every 24 hours was found to achieve the most appropriate therapeutic levels. On the other hand, a dose of 500mg every 6 hours showed a poor percentage of the concentration over the toxic level.