- 著者
- 尾崎 庄一郎 秋山 隆彦 森田 剛夫 久米川 昌浩 長瀬 敏夫 上原 宣昭 星 昭夫
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.38, no.11, pp.3164-3166, 1990-11-25 (Released:2008-03-31)
- 参考文献数
- 17
- 被引用文献数
- 12 12
Various kinds of 5'-O-unsaturated acyl 5-fluorouridines were synthesized to obtain 5-fluorouridine derivatives with low toxicity and high antitumor activity. Antitumor activity of the compounds against L-1210 leukemia in mice was examined, and the 5'-O-4-opentenoyl derivative showed the highest antitumor activity.