- 著者
- 尾崎 庄一郎 秋山 隆彦 森田 剛夫 久米川 昌浩 長瀬 敏夫 上原 宣昭 星 昭夫
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.38, no.11, pp.3164-3166, 1990-11-25 (Released:2008-03-31)
- 参考文献数
- 17
- 被引用文献数
- 12 12
Various kinds of 5'-O-unsaturated acyl 5-fluorouridines were synthesized to obtain 5-fluorouridine derivatives with low toxicity and high antitumor activity. Antitumor activity of the compounds against L-1210 leukemia in mice was examined, and the 5'-O-4-opentenoyl derivative showed the highest antitumor activity.
1 0 0 0 OA 5-Fluorouracil Dirivatives. XVII. : Synthesis and Antitumor Activity of 5'-O-Acyl-5-fluorouridines
- 著者
- 尾崎 庄一郎 秋山 隆彦 池 祥雅 森 春樹 星 昭夫
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.37, no.12, pp.3405-3408, 1989-12-25 (Released:2008-03-31)
- 参考文献数
- 13
- 被引用文献数
- 14 15
With the aim of diminishing the toxicity of 5-fluorouridine (1) and obtaining biologically active derivatives of 1, various kinds of 5'-O-acyl-8-fluorouridines 2 were synthesized. The antitumor activity of the compounds against L-1210 leukemia in mice was examined. The 5'-O-heptanoyl derivative 2h showed the highest antitumor activity.