著者

森田 邦正 松枝 隆彦 飯田 隆雄

出版者

公益社団法人 日本薬学会

雑誌

衛生化学 (ISSN:0013273X)

巻号頁・発行日

vol.43, no.1, pp.42-47, 1997-02-28 (Released:2008-05-30)

参考文献数

27

被引用文献数

4 5

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The present paper presents the liver distribution and fecal excretion of polychlorinated dibenzo-p-dioxins (PCDDs) congeners, such as 1, 2, 3, 7, 8-P5CDD, 1, 2, 3, 6, 7, 8-H6CDD, 1, 2, 3, 7, 8, 9-H6CDD and 1, 2, 3, 4, 6, 7, 8-H7CDD, in male rats fed with Chlorella, Spirulina and chlorophyllin. The objective of this study is to evaluate the effect on PCDD excretion by the chlorophyllin foods. The rats were given some treatment diets containing 20% Chlorella. 20% Spirulina, 0.2, 2% chlorophyllin, 10% rice-bran fiber or 0.2% chlorophyllin + 10% rice-bran fiber for 5 d. Then, the animals were administered 4 g of each diet containing 0.5 ml of the causal rice-bran oil of Yusho that had occurred in the Southwest part of Japan in 1968 and kept on the same diet for another 5 d. The rice-bran oil contaminated with 1, 2, 3, 7, 8-P5CDD (6.86 ng/ml), 1, 2, 3, 6, 7, 8-H6CDD (31.4 ng/ml), 1, 2, 3, 7, 8, 9-H6CDD (22.4 ng/ml) and 1, 2, 3, 4, 6, 7, 8-H7CDD (121.7 ng/ml) was used for the animal experiments. PCDD congeners in the feces and liver were analyzed by high resolution gas chromatography-mass spectrometry. The fecal excretion of 1, 2, 3, 7, 8-P5CDD in the groups fed with Chlorella, Spirulina and 2% chlorophyllin were 7.4, 7.1 and 11.0 times higher (p<0.01), respectively, than that in the control group. Moreover, the fecal excretion of 1, 2, 3, 6, 7, 8-H6CDD, 1, 2, 3, 7, 8, 9-H6CDD and 1, 2, 3, 4, 6, 7, 8-H7CDD in the same groups were 4.4-5.3, 2.7-3.7 and 1.7-2.8 times higher, respectively, than that in the control group. These findings suggest that administration of Chlorella, Spirulina and chlorophyllin is useful as a new approach in the treatment of patients exposed to lipophilic xenobiotics.

著者

森田 邦正

出版者

公益社団法人 日本薬学会

雑誌

衛生化学 (ISSN:0013273X)

巻号頁・発行日

vol.33, no.3, pp.185-190, 1987-06-30 (Released:2008-05-30)

参考文献数

19

被引用文献数

1 1

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The daily intakes of dietary fiber (DF) for the period from 1949 to 1984 were calculated according to national nutrition survey in Japan. The daily intake of DF had gradually decreased during the period from 1949 (17.9 g) to 1984 (14.2 g). The daily intake of cellulose, had slightly decreased during the period from 1949 (8.5 g) to 1970 (6.8 g) and its recent intake was 7.6 g. The daily intake of hemicellulose, which had decreased during the period from 1949 (5.7 g) to 1965 (4.0 g), was about 4.1 g after 1965. The daily intake of lignin, which showed a certain trend during the period from 1949 (3.7 g) to 1971 (3.8 g), suggested a remarkable decrease after 1972. The DF intakes of 12 individuals aged from 30 to 50 years were determined by duplicate collection of food consumed for three successive days. The individual intake of DF was varied from 6.6 g to 16.5 g per day. The average intake and standard deviation was 10.7±1.6 g. A correlation between DF consumption and the death rate of colon cancer from 1950 to 1984 was apparent (γ=-0.739, p<0.01). A negative correlation existed between the intake of hemicellulose and lignin and the death rate of colon cancer (γ=-0.689 and γ=-0.918). A correlation between DF consumption and the death rate of rectum cancer was highly significant (γ=-0.793, p<0.01). A negative correlation existed also between the intake of hemicellulose and lignin and the death rate of rectum cancer (γ=-0.786 and γ=-0.895).