- 著者
- 渡辺 大一 福谷 俊 伊川 博 山浦 哲明 加瀬 則子 水谷 弘子
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.34, no.11, pp.4855-4858, 1986-11-25 (Released:2008-03-31)
- 参考文献数
- 8
- 被引用文献数
- 2 2
Two crystal forms of the new dihydropyridine derivative, methyl (E)-3-phenyl-2-propen-1-yl 1, 4-dihydro-2, 6-dimethyl-4-(3-nitrophenyl)pyridine-3, 5-dicarboxylate (FRC-8411), were obtained by recrystallization from methanol. These crystal forms were identified by using powder X-ray diffractometry, infrared spectroscopy, differential scanning calorimetry (DSC) and thermogravimetry. By means of DSC, the melting points of forms I and II were found to be 140 and 121°C, respectively.Forms I and II, having a similar particle size distribution, were administered orally or intravenously to spontaneously hypertensive rats. In the case of oral administration, the hypotensive action of form I was milder than that of form II and tachycardia was not observed after administration of form I.