著者

永松 健

出版者

日本脂質栄養学会

雑誌

脂質栄養学 (ISSN:13434594)

巻号頁・発行日

vol.31, no.1, pp.30-35, 2022-03-31 (Released:2022-06-17)

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Preterm birth occurs in 5% of all pregnancies in Japan, giving a life-long adverse impact on the baby. The regulation of inflammation balance in the uteroplacental system is a key to successful pregnancy. Deterioration of inflammatory regulation in the pregnant uterus is a major factor related to preterm birth. Inflammatory eicosanoids such as prostaglandin (PG)F2α and PGE2, are produced by the omega-6 fatty acid metabolic pathway and play an essential role in the progress of parturition controlling cervical ripening and uterine contraction. In contrast, accumulating evidence have suggested that the metabolic pathway of omega-3 fatty acids is closely involved in pregnancy maintenance with its anti-inflammatory functions physiologically against omega-6-derived substances. Past studies have implied that enhanced intake of omega-3 fatty acid in pregnant women reduces the incidence of preterm birth. Supporting those clinical findings, we previously found that fat-1 transgenic mice which have an omega-3 fatty acid-dominant internal environment were resistant to inflammation induced preterm birth. In the background mechanism, we confirmed that omega-3 fatty acid metabolites such as resolvin and 18-HEPE suppressed uterine inflammation. In this review article, the importance of omega-3 fatty acids in the control of uterine inflammation is discussed from a wide range of perspectives from basic researches to clinical intervention in pregnant women.

著者

永松 健太郎 藤井 寛之 阿部 憲孝

出版者

基礎有機化学会(基礎有機化学連合討論会)

雑誌

基礎有機化学討論会要旨集(基礎有機化学連合討論会予稿集)

巻号頁・発行日

vol.17, pp.282-282, 2004

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3-フェニル-8-トリフェニルホスホイミノ-1-アザアズレン(1)とイソシアナート類との反応を検討した。1とアリールイソシアナートとの反応では2-アリールイミノジアザシクロペンタ[cd]アズレン誘導体と1,8-ジヒドロ-8-アリールイミノ-1-アザアズレン誘導体が得られた。1とトシルイソシアナートとの反応では、イオウが脱離し、トリル基が転位した環化生成物が得られた。生成物の構造はX線結晶解析により決定した。得られる8-アミノ-1-アザアズレン誘導体の互変異性について、X線結晶解析と分子軌道計算により検討したので、これについても述べる。