著者

江上 不二夫

出版者

公益社団法人 日本農芸化学会

雑誌

化学と生物 (ISSN:0453073X)

巻号頁・発行日

vol.18, no.7, pp.410-415, 1980-07-25 (Released:2009-05-25)

参考文献数

14

著者

Oparin A.I. 江上 不二夫 板橋 美智子

出版者

岩波書店

雑誌

科学 (ISSN:00227625)

巻号頁・発行日

vol.23, no.9, pp.453-457, 1953-09

著者

福岡 文子 徳善 玲子 星 昭夫 江上 不二夫 長沢 金蔵 加藤 好雄

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.60, no.2, pp.187-197, 1969-04-30 (Released:2008-10-23)

参考文献数

21

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Derivatives of 2-acylamido-6-purinethiol and/or 2-acylamido-9-alkyl-6-purinethiol were synthesized and the 2-acylamide derivatives were compared with the parent compound as to their antitumor activity and toxicity. The antitumor activity was assayed mostly with NF-sarcoma, which is known to be highly sensitive to this class of nucleic acid base analogs, but also using other types of tumors.Among the 2-acylamide derivatives, formamide and especially isobutyroylamide derivatives were found to be the most active, but not markedly more active than the parent compound. A slight decrease in the toxicity was noted among the derivatives with high antitumor activity.