著者

加藤 好雄

出版者

一般社団法人 映像情報メディア学会

雑誌

テレビジョン学会誌 (ISSN:03866831)

巻号頁・発行日

vol.37, no.4, pp.255-258, 1983-04-20 (Released:2011-03-14)

著者

福岡 文子 徳善 玲子 星 昭夫 江上 不二夫 長沢 金蔵 加藤 好雄

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.60, no.2, pp.187-197, 1969-04-30 (Released:2008-10-23)

参考文献数

21

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Derivatives of 2-acylamido-6-purinethiol and/or 2-acylamido-9-alkyl-6-purinethiol were synthesized and the 2-acylamide derivatives were compared with the parent compound as to their antitumor activity and toxicity. The antitumor activity was assayed mostly with NF-sarcoma, which is known to be highly sensitive to this class of nucleic acid base analogs, but also using other types of tumors.Among the 2-acylamide derivatives, formamide and especially isobutyroylamide derivatives were found to be the most active, but not markedly more active than the parent compound. A slight decrease in the toxicity was noted among the derivatives with high antitumor activity.