著者

古閑 健二郎 大嶋 耐之 河島 進

出版者

日本病院薬剤師会

雑誌

病院薬学 = Journal of the Nippon Hospital Pharmacists Association (ISSN:03899098)

巻号頁・発行日

vol.21, no.2, pp.166-169, 1995-04-10

参考文献数

6

被引用文献数

1

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To recognize the existing state of simultaneous use ("Gappo") of Kampo extract medicines, we investigated the medicines from 3099 prescription preparations. The results were as follows: 1) The rate of two and three combined preparations was 10.1% and 0.8%, and combined kinds being 98 and 14, respectively. 2) Rate of non-reducing dose prescriptions among combined preparations was 19.1%. 3) The rate of combined kinds of crude drug from single to three comprised 70% among two combined preparations, and the rate of the major crude drug, Glycyrrhizae Radix, was 25.6%.

著者

河島 進 井上 陽子 示野 哲也 藤原 洋

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.38, no.2, pp.498-505, 1990-02-25

被引用文献数

2

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Rectal absorption of morphine from various kinds of suppository bases was investigated. The extent of bioavailability of morphine by rectal administration varied with the bases used (30.5-97.5%), but every value was higher than that in the case of oral administration (13.5%). Witepsol bases were preferable to macrogol base for the rectal absorption of morphine. In particular, Witepsol S-55 or W-35 gave a higher plasma peak level than H-15 or E-75,whereas the difference in the mean residence times obtained from these bases could not be regarded as significant. Sustained-release suppositories of morphine could be prepared simply by mixing alginic acid (Alg) with morphine in a suppository base. Further, prolonged rectal absorption could be obtained by using these sustained-release suppositories, and the absorption rate was controlled by the amount of Alg added. It seems likely that the sustained release was due to the binding of morphine to Alg from the results of partition coefficient and binding ratio measurements in aqueous solution. The rapid initial absorption and the subsequent prolonged absorption of morphine simultaneously obtained from the morphine-Alg suppository may be useful in the clinical context.