著者

伊藤 宗元 大黒 久子 篠田 孝司 佐藤 桃子 渡部 健次

出版者

一般社団法人 国立医療学会

雑誌

医療 (ISSN:00211699)

巻号頁・発行日

vol.23, no.6, pp.764-770, 1969 (Released:2011-10-19)

参考文献数

10

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We observed alteration of the behavior of coagulation factors during menstrual cycle by examination of nine kinds of test every week upon 12 healthy single females. At the same time we examined 5 healthy males in same way as a cotrast.The items of test are platelet count, bleeding time, coagulation time, capillary fragility (negative pressure), clot retraction, prothrombin time, recalcification time, partial thromboplastin time and serum fibrinogen.We obtained the following results;After period, there are definite increase of platelet count, prolongation of bleeding time, slight prolongation of recalcification time and prothrombin time. During period, coagulation time is shortened slightly and clot retraction became stable as 40∼50%. There is temporal decrease of capillary resistence after period, partial thromboplastin time much prolonged in one to two weeks after period. Serum fibrinogen increased slightly after period.The alteration of the behavior of coagulation factors during menstmal cycle are supposed to be affected by the age, marriage, delivery, amount of bleeding at period and length of menstrual cycle, because of which we should interpret results in consideration of the alteration during menstrual cycle in laboratory study.

著者

伊藤 宗元 猿田 栄助 渡部 健次 吉田 君江 渡辺 チョ

出版者

一般社団法人 国立医療学会

雑誌

医療

巻号頁・発行日

vol.19, no.6, pp.448-452, 1965

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Recently it has been recognized again that importance of fibrinogen on clinical field, while the method of fibrinogen assay required a lot of time and skillful work, which disturbed to get quick results on clinical use.<br>Authors have been measuring plasma fibrinogen upon several diseases by a turbidimetric method using ammonium sulfate according to Fowell who first described in 1955 and we followed up their changes related with the age, menstruation and course of diseases.<br>The average value of plasma fibrinogen among 10 healthy male (age between 23-41) was 362.2mg%, and 10 healthy female (age between 17-32) was 388.5mg%. During premenstrual and menstrual period of healthy female showed apparent increase of that value.<br>Nineteen cases of lung cancer was high as much as average 907.4mg%, while 15 cases of the other part of cancer (gastric, hepatic and uterine) showed average 590.3mg% of fibrinogen.<br>The far advanced pulmonary tuberculosis showed apparent increased value than the mild cases. Pleurisy revealed highest value among tuberculosis, while it decreased to normal value by adequate treatment.<br>Unfortunately we have not experienced any case of afibrinogenemia (both of the congenital and secondary), which has been noted to be the most frequent cause of massive hemorrhage during delivery.<br>The plasma fibrinogen among the other diseases were as follows: 1) normal value in acute leucemia and aplastic anemia, 2) slight increase in allergic purpura, 3) apparent increase in multiple myeloma, 4) increase or decrease in hepatitis, different by the type of disease, 5) slight increase in hypertensives and and diabetics.