著者

濱 宏仁 森本 茂文

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.45, no.1, pp.21-27, 2019-01-10 (Released:2020-01-10)

参考文献数

9

---

When microbes present on the rubber stopper in a vial or attachment part of closed system drug transfer devices (CSTD), these microbes may contaminate vials by needle puncture. We examined the preservation of sterility in vials by different vial storage conditions on the premise of divided use of single-use vials. Experiments were conducted using liquid medium filled vials under the following conditions A-D. [A: Removed rubber stoppers (open-vials) and placed in safety cabinet (BSC), B: Placed open-vials in preparation room (ISO class 8), C: Placed negative-pressured vials with rubber stopper punctured twice by needle in preparation room, D: Placed the vials connected to CSTD in preparation room.] After 24 hours and 7 days, portions of the culture medium in the vial were cultured. In conditions A, C and D, no growth of microbes was confirmed except in B. Microbial contamination didn't occur when vials were stored in BSC. When the vials were stored under the ISO Class 8 environment, it is suggested that microbes may adhere to the rubber stopper of the vial. Even if the inside of the vial after puncture was negative pressure, the rubber stopper showed a certain protective effect from microorganism adherence, and CSTD was similar. Therefore, the vial storage condition in BSC (ISO class 5) is considered preferable on the premise that a single use vial is divided. However, if the rubber stopper or CSTD is connected even in an ISO class 8 environment, the sterility is retained for 7 days.

著者

森 良江 濱 宏仁 西村 亮 中浴 伸二 森本 茂文

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.46, no.4, pp.222-229, 2020-04-10 (Released:2021-04-10)

参考文献数

14

---

This study clarifies the storage situation of drugs that require light-protection at patients’ homes, and reveals the proper storage conditions of these drugs.We interviewed inpatients about the storage situation of drugs for light-protection. In addition, we measured light illuminance on the desktop (J), inside of a storage case (C) of the pill-shelf, inside medicine envelopes: white-color (YW), pink-color (YP) and black inside (YB), and lightproof plastic bags (S) at our prescription department.Eighty-four percent of patients were not consciously protecting the drugs from light at home. As for the storage form of those patients, “storage in medicine envelopes / storage in non-lightproof plastic bags with a sealer or pill case / storage from medicine envelopes as is” were respectively 43, 41, and 17 percent. The illuminance of J was 696-811 lx. The illuminance of C, YW, YP, YB and S decreased to values corresponding to 6-13, 21-22, 15, 0.9, and 0.3-0.4 percent against J, respectively. We found that many patients have problems with drug storage situations.As a result of the illuminance measurement, it was clear that storage in C and each medicine envelope have certain light protection effects. It was considered that YB might be useful as a storage condition for drugs that require light-protection, because a shielding effect of 99 percent was observed under 800 lx. These results were one indicator of the effects of exposure to light depending on the storage condition of the drug.