著者

井口 貞彦 岩村 浩幸 西崎 稔 林 昭夫 瀬の口 和彦 小林 馨 坂木 克人 蜂谷 勝敏 市岡 由美子 川村 雅範

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.40, no.6, pp.1462-1469, 1992-06-25 (Released:2008-03-31)

参考文献数

12

被引用文献数

115 152

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A novel, highly cardioselective ultra short-acting β-blocker, ONO-1101, has been developed for application in the emergency treatment of tachycardia and better control of heart rate in surgery. This agent is approximately nine times more potent in β-blocking activity in vivo and eight times more cardioselective in vitro than esmolol. This β-blocking drug has a short duration of activity, enabling rapid recovery after cessation of administration if side effects occur. It can be used safely in patients suffering from acute heart disease and represents a major therapeutic advance in the treatment of heart disease.