- 著者
- 妹尾 春樹 畑 隆一郎
- 出版者
- 公益社団法人 日本ビタミン学会
- 雑誌
- ビタミン (ISSN:0006386X)
- 巻号頁・発行日
- vol.68, no.9, pp.501-513, 1994-09-25 (Released:2018-03-30)
Stellate cells (vitamin A-storing cells, lipocytes, fat-storing cells, Ito cells) exist in the perisinusoidal space of the hepatic lobule, and store 80% of retinoids in the whole body as retinyl palmitate in lipid droplets in the cytoplasm. Under physiological conditions, these cells play key roles in the control of retinoid homeostasis ; they express specific receptors for retinol-binding protein (RBP), a binding protein specific for retinol, on their cell surface, and take up the complex of retinol and RBP by receptor-mediated endocytosis. Whereas, under pathological conditions such as liver cirrhosis, these cells lose retinoids, and synthesize a large amount of extracellular matrix (ECM) components including collagen, proteoglycan and adhesive glycoproteins. Morphology of these cells also changes from the star-shaped stellate cells to that of fibroblasts or myofibroblasts. ECM components regulate the morphology, proliferation, and functions of the stellate cells. L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative, further modulates this cellular regulation by ECM components.
- 著者
- 畑 隆一郎 妹尾 春樹
- 出版者
- 公益社団法人 日本ビタミン学会
- 雑誌
- ビタミン (ISSN:0006386X)
- 巻号頁・発行日
- vol.69, no.12, pp.675-688, 1995-12-25 (Released:2017-12-08)
- 参考文献数
- 44
- 被引用文献数
- 1
L-Ascorbic acid 2-phosphate (Asc 2-P), a long-acting vitamin C derivative, stimulates collagen accumulation, cell proliferation, and formation of a three-dimensional tissue (dermis) by skin fibroblasts. Investigation of molecular mechanisms of Asc 2-P action indicated that it stimulates maturation of extracellular matrix (ECM) by activating transcription of genes for type I collagen which form a back-bone structure of the ECM. Asc 2-P also stimulates differentiation and maintains differentiated phenotypes of various kinds of cells of epithelial and mesenchymal origin. Asc 2-P may be useful to clarify new physiological functions of vitamin C and investigation of the molecular mechanisms.