著者
妹尾 春樹 畑 隆一郎
出版者
公益社団法人 日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.68, no.9, pp.501-513, 1994-09-25 (Released:2018-03-30)

Stellate cells (vitamin A-storing cells, lipocytes, fat-storing cells, Ito cells) exist in the perisinusoidal space of the hepatic lobule, and store 80% of retinoids in the whole body as retinyl palmitate in lipid droplets in the cytoplasm. Under physiological conditions, these cells play key roles in the control of retinoid homeostasis ; they express specific receptors for retinol-binding protein (RBP), a binding protein specific for retinol, on their cell surface, and take up the complex of retinol and RBP by receptor-mediated endocytosis. Whereas, under pathological conditions such as liver cirrhosis, these cells lose retinoids, and synthesize a large amount of extracellular matrix (ECM) components including collagen, proteoglycan and adhesive glycoproteins. Morphology of these cells also changes from the star-shaped stellate cells to that of fibroblasts or myofibroblasts. ECM components regulate the morphology, proliferation, and functions of the stellate cells. L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative, further modulates this cellular regulation by ECM components.
著者
青山 みさ子 四童子 好廣 山口 義彦 貞森 直樹
出版者
公益社団法人 日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.82, no.3, pp.179-185, 2008
参考文献数
11

Single-nucleotide polymorphisms (SNPs) of the mitochondrial NADH dehydrogenase subunit-2 (ND2) andβ3-adrenergic receptor (BAR3) genes are well established to be associated with life style-related diseases. The ND2 gene variant (Mt5178A) is associated with longevity or less susceptibility to adult-onset diseases. The BAR3 gene allelic variant (Trp64Arg and Arg64Arg) is linked with obesity or non-insulin-dependent diabetes mellitus. We investigated whether the combination of these 2 genes affect eating behavior, and found that the BAR3-normal (Trp64Trp)+ND2-variant (Mt5178A) group preferred much carbohydrate and less animal protein, Vitamin B_2 (B_<2)>, calcium in comparison with the other genetic groups. Less intake of B_2 was principally associated with Mt5178A in this group. Taking account that flavin adenine dinucleotide is a coenzyme of the NADH dehydrogenase which composes the proton-pumping complex I of the mitochondrial electron transport system, the association between Mt5178A variant and less B_2 intake is tremendously interesting. In this paper, we discuss a possible association between genetic polymorphism and eating behavior by summarizing our own research data.
著者
美濃 眞
出版者
公益社団法人 日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.74, no.10, pp.501-515, 2000-10-25 (Released:2017-12-26)
参考文献数
29
被引用文献数
4 or 0

現在, 臨床検査企業の数社でビタミンの測定が行われているが, 測定ビタミン値に関しては精度管理機構もなく, また各社の測定法の実態も不明である. したがって, 依頼者に報告されるビタミンの測定値の信頼性もまったく企業各社に依存した状態であるので, それらのビタミン測定値の正確さと信頼性を確立して貰うために, 日本ビタミン学会では本学会において臨床検体の測定にかかわっている, 各ビタミンの研究者による臨床検査検体試料のビタミン測定法を掲載することとした.