著者

天野 晶子 石神 昭人

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.83, no.1, pp.24-26, 2009-01-25 (Released:2017-10-10)

参考文献数

21

被引用文献数

1

著者

小島 彩子 尾関 彩 中西 朋子 佐藤 陽子 千葉 剛 阿部 皓一 梅垣 敬三

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.91, no.2, pp.87-112, 2018 (Released:2018-04-12)

著者

津川 尚子 桒原 晶子 浦 千尋 小笠原 帆南 水野 敬 渡辺 恭良 田中 清

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.95, no.3, pp.101-102, 2021 (Released:2022-03-31)

著者

内尾 隆正 広瀬 義隆 室崎 伸二 山本 佳弘 石神 昭人

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.91, no.5.6, pp.352-354, 2017 (Released:2018-06-30)

著者

鏡山 博行

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.94, no.2, pp.104-105, 2020-02-25 (Released:2021-02-28)

著者

池田 彩子 野村 早

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.89, no.9, pp.453-458, 2015-09-25 (Released:2017-08-10)

被引用文献数

2

著者

平岡 真実 香川 靖雄

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.89, no.2, pp.59-64, 2015-02-25 (Released:2017-08-10)

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It is known that individuals respond differently to the same dietary intake differently. Nutrigenetics is an essential discipline to study gene-based differences in response to dietary components for nutrition and dietetics practice. One of the best-known examples for nutrigenetics is the polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T. The presence of the C677T mutation in MTHFR gene is associated with a reduction of MTHFR enzyme activity. This reduction of MTHFR enzyme activity may cause an increase in plasma homocysteine level which becomes risk factors for cardiovascular disease, cognitive impairment and neural tube defects. Plasma homocysteine level is responsive to intervention with folic acid and related vitamin B group. "Sakado Folate Projects" is a health promotion with personalized nutrition intervention based on MTHFR C677T polymorphisms for prevention of these diseases associated with hyperhomocysteinemia. An increase in serum folate level and a decrease in serum homocysteine level were observed at 4 months after the onset of this intervention and these changes were particularly marked in individuals with TT genotype. This finding suggests that personalized nutrition intervention based on genetic information is effective in motivating individuals to change their lifestyle habit.

著者

糸川 嘉則

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.77, no.1, pp.3-10, 2003-01-25 (Released:2017-12-26)

参考文献数

17

被引用文献数

1

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In 1960, the author started a thiamine research at Department of Hygiene, Faculty of Medicine, Kyoto University, under Professor Fujiwara's guidance. Allithiamine, a lipotropic derivative of thiamine, enters cells in direct proportion to dosage by passive diffusion and then is quickly converted to thiamine intracellularly. The author used allithiamine labeled with S^<35> on sulfur in the S-propyl group [TPD-S^<35>(outer)] and labeled with S^<35> on sulfur in the thiazole group [TPD-S^<35>(inner)]. It was found that allithiamine split in vivo at the -S-S- linkage into the thiamine portion and propylmercapto group. The thiamine part penetrated in large amount into the blood cells, while the majority of S^<35> from propylmercapto group was found in plasma after oral or parenteral administration of allithiamine. From 1967 to 1969, the author conducted some studies on nonenzymatic role of thiamine in nervous function with Professor J. R. Cooper at Yale University, U.S.A. and these results suggested that thiamine played an important role in the function of the sodium channel in nerve membranes. However, a hypothesis that thiamine triphosphate might play a role in this function could not be elucidated. The methodology which we adopted at that time was so primitive to clarify the problems. In 1979, the author was appointed as the professor and chiarman of Department of Hygiene, one of the field of social medicine, and the author had to include some researches with a tinge of social medicine into our research projects besides the biochemical studies. Amyotrophic lateral sclerosis was prevalent in the Muro district in Wakayama Prefecture and magnesium content in drinking water from this area was lower than water from the other districts in Japan. In 1962, we investigated thiamine metabolism of these patients and found that the patients had lost the ability to utilize thiamine. This finding drived me to start the another research project on the clarifica tion of relationship between thiamine and magnesium metabolism. Since then, variety of researches on two major fields, i.e. vitamins and minerals, had been carried out by our research group. The author would be very glad if this article could be helpful for young researchers to develop their future researches on vitamins by learning from our researches including unsuccessful ones, "Hanmenkyoshi" in Japanese.

著者

田中 清 青 未空

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.91, no.10, pp.621-623, 2017 (Released:2018-10-31)

著者

道家 晶子 柘植 治人

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.67, no.3, pp.144-145, 1993-03-25 (Released:2018-03-30)

著者

新 真理子

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.81, no.3, pp.110-112, 2007-03-25 (Released:2017-10-10)

参考文献数

12

著者

片岡 洋祐

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.90, no.4, pp.167-168, 2016 (Released:2017-12-26)

著者

森下 雄太 田井 章博

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.90, no.8, pp.398-401, 2016 (Released:2017-12-26)

被引用文献数

1

著者

梅垣 敬三 尾関 彩 西島 千陽 佐藤 陽子 千葉 剛

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.91, no.12, pp.696-701, 2017 (Released:2018-12-31)

被引用文献数

1

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There is concern about the occurrence of adverse events related to the use of supplements containing vitamins and minerals, but the actual condition is not understood well. Therefore, we examined the characteristics of adverse events due to the use of supplements containing vitamins and minerals by extracting the adverse events from the database in “Information system on safety and effectiveness for health food(HFNET)”, which collects health food reports both inside and outside the country. Eighty-five adverse cases (domestic 24, foreign 61) were extracted from the HFNET by July 2016. The data revealed that the causal factors of adverse events due to the use of supplements containing vitamins and minerals were their overdose, their use as the medicine, their concomitant use with other medicines, and their use by infants and sick people. Although many cases were due to the use of vitamin D supplement, most of the cases were related with its overdose found in overseas. To ensure the safety of supplements containing vitamins and minerals, it would be necessary to pay attention to their use by vulnerable individuals including infants and sick people, their overdose, and their use in combination with other medicines.

著者

宮内 正厚 中島 英彰 平井 千津子

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.88, no.7, pp.349-357, 2014-07-25 (Released:2017-08-10)

被引用文献数

1

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In recent years, the importance of solar exposure for vitamin D synthesis in the human body has been pointed out. The solar exposure time necessary for the synthesis of vitamin D depends largely on geographical location, season, time of day, weather, exposed skin area, etc. Using numerical simulations we estimated that if 10 μg vitamin D were to be synthesized entirely by solar exposure to skin type III (SPT), which is considered to be the most typical skin type for Japanese people, it would necessitate 6.4 min horizontal exposure of a 600 cm^2 skin area, corresponding to the face and the back of both hands, under cloudless sky at 12:00 o'clock in July in Tsukuba. Under the same conditions, it would take 20.8 min to reach 1 MED (Minimum Erythemal Dose) which is thought to be the harmful UV exposure level for human skin. In other words, approximately 31% of the time before the skin gets red is enough for the synthesis of 10 μg vitamin D a day. On the other hand, in Sapporo which is located in the northern part of the Japanese Archipelago, the corresponding durations are 8.4 min and 27.0 min, respectively under the same conditions as in Tsukuba, whereas the necessary time in December would be 139 min and 296 min, respectively. Although the sufficient amount of vitamin D cannot be obtained by short-time exposure to solar radiation, it is thought that long-time exposure might not damage the skin. It can be concluded that for a skin area of 600 cm^2 in horizontal position, exposure time until damage would occur is generally 3 times larger than what is necessary for the synthesis of 10 μg vitamin D under strong UV radiation. It should be noted that generally, with a larger exposed skin area the solar exposure time for vitamin D synthesis could be considerably shortened.

著者

味園 春雄 芦内 誠

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.79, no.2, pp.71-78, 2005-02-25 (Released:2017-10-10)

参考文献数

23

被引用文献数

1

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最近, 納豆が健康食品として注目されているが, 「納豆の糸」の主成分はポリ-γ-グルタミン酸(PGA)であり, D-グルタミン酸を多く含んでいる. また, PGAには多彩な機能があり, その有用性にも注目が集まっている. しかしながら, 納豆菌のPGA生合成機構は長い間不明であった. 本稿では, PGAの色々な機能や生合成機構について紹介する.1. ポリ-γ-グルタミン酸の構造と機能 PGAはグルタミン酸のγ-カルボキシル基とα-アミノ基がイソペプチド結合で連なったポリマーである. 主として納豆菌(Bacillus subtilis)などのBacillus属細菌によって生産されるが, 好塩古細菌Natrialba aegyptiacaや腔腸動物であるヒドラもPGAを生産する. その分子質量は1万ぐらいのものから100万を越えるものもある(表1). 炭疽菌Bacillus anthraciの生産するPGAはD-グルタミン酸のみから構成されているが, 好アルカリ性細菌Bacillus haloduransやN. aegyptiaca, ヒドラL-グルタミン酸からなるPGAを生産する.

著者

高田

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.12, pp.123, 1957 (Released:2017-12-22)

著者

小島 彩子 尾関 彩 中西 朋子 佐藤 陽子 千葉 剛 阿部 皓一 梅垣 敬三

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.91, no.1, pp.1-27, 2017 (Released:2018-04-12)

著者

桒原 晶子 津川 尚子 水野 敬 小笠原 帆南 渡辺 恭良 田中 清

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.93, no.7, pp.296-298, 2019-07-25 (Released:2020-07-31)

著者

天野 晶子 石神 昭人

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.87, no.9, pp.492-496, 2013-09-25 (Released:2017-08-10)

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Vitamin C (VC, L-ascorbic acid) transport is mediated by specific transporters, such as sodium-dependent vitamin C transporter (SVCT) 1 and 2. SVCT1 and 2 have a functional role in secondary active transport of VC from the outside to the inside of cells at the expense of sodium electrochemical gradient across the cell membrane. Recent studies revealed that the effect of SVCTs gene polymorphisms on risk of preterm birth and any diseases. Moreover, some paper reported that the effect of SVCTs gene polymorphisms on VC concentration in human blood and interactions with other antioxidant related genes. In this paper, we review recent insights into the relationships between SVCTs gene polymorphisms and health and disease risk.