著者
井上 裕康
出版者
公益社団法人 日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.78, no.12, pp.621-623, 2004-12-25 (Released:2017-10-10)
参考文献数
13

レスベラトロールは赤ワインに含まれる抗酸化作用を持つフィトアレキシン(抗菌性物質)である. レスベラトロールは中等度のワイン消費が心血管病, 脳卒中, 痴呆の危険度と負の相関を示す, いわゆる「フレンチパラドックス」に関与する物質と考えられてきた. 我々は最近, レスベラトロールが核内受容体PPAR(peroxisome proliferators activated receptor)αとPPARγを選択的に活性化すること, さらにPPARα活性化が脳保護効果をもたらすことを見いだした. これらの知見は「フレンチパラドックス」を説明する新しい作用機構を提供すると考えている. 一方で, レスベラトロールは寿命延長効果を持つカロリー制限模倣物質であること, オレイルエタノールアミドがPPARαの新しい内因性リガンドであり, その活性化によって食欲をコントロールすることが報告されている. そこでこれらの知見を含めて, 今後の展望とともに紹介したい.
著者
妹尾 春樹 畑 隆一郎
出版者
公益社団法人 日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.68, no.9, pp.501-513, 1994-09-25 (Released:2018-03-30)

Stellate cells (vitamin A-storing cells, lipocytes, fat-storing cells, Ito cells) exist in the perisinusoidal space of the hepatic lobule, and store 80% of retinoids in the whole body as retinyl palmitate in lipid droplets in the cytoplasm. Under physiological conditions, these cells play key roles in the control of retinoid homeostasis ; they express specific receptors for retinol-binding protein (RBP), a binding protein specific for retinol, on their cell surface, and take up the complex of retinol and RBP by receptor-mediated endocytosis. Whereas, under pathological conditions such as liver cirrhosis, these cells lose retinoids, and synthesize a large amount of extracellular matrix (ECM) components including collagen, proteoglycan and adhesive glycoproteins. Morphology of these cells also changes from the star-shaped stellate cells to that of fibroblasts or myofibroblasts. ECM components regulate the morphology, proliferation, and functions of the stellate cells. L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative, further modulates this cellular regulation by ECM components.
著者
矢野 友啓
出版者
公益社団法人 日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.89, no.12, pp.561-572, 2015-12-25 (Released:2017-08-10)

It is well known that vitamin E acts as a useful preventive agent against several types of cancers and stroke. However, there are conflicting results on a role of vitamin E in the prevention of these diseases. In order to clarify the conflicting results, meta-analysis of current results obtained from randomized controlled trials (RCTs) was conducted. Meta-analysis of 7 RCTs on cancer identified showed no significant difference on the effect of vitamin E supplementation on incidence and mortality in cancers tested. However, there was heterogeneity in the meta-analysis of prostate cancer incidence, indicating the possibility that vitamin E supplementation has a suppressive effect against the cancer in some cases. With respect to incidence and mortality in stroke, meta-analysis of 6 RCTs identified was conducted, and vitamin E supplementation significantly reduced the incidence of ischemic stroke, but not hemorrhagic stroke. Thus, it is suggested that vitamin E supplementation has a preventive effect on ischemic stroke.
著者
久保寺 登
出版者
公益社団法人 日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.87, no.2, pp.95-103, 2013-02-25 (Released:2017-08-10)
参考文献数
35

In vitamin D research, there are three milestones from the perspective of pharmaceutical studies. The first represents the early stage of vitamin D research and involves the discovery of vitamin D and its physiological significance as an anti-rickets factor. The second is the elucidation of the vitamin D activation pathway in the body and the discovery of the biologically active metabolites of vitamin D. The clinical application of active vitamin D or its prodrug was also attempted to make up for the deficiency caused by poor vitamin D activation. The third is characterized by the discovery of the differentiation-inducing properties of active vitamin D. This showed the diversity of the physiological actions of active vitamin D, which initially had been thought only to contribute to bone and calcium metabolism. Because these physiological actions were clinically useful, the third discovery revealed opportunities for the development of drugs appropriate to specific purposes by synthesizing analogs to separate biological effects. Active vitamin D analogs based on the findings during the third milestone are now commercially available and are contributing to current clinical practice. This article discusses the various milestones outlining vitamin D and analogs in terms of clinical applications and pharmaceutical studies.
著者
小嶋 良種 吉川 豊 飯倉 奈美 上田 理恵 市村 彰男 土江 松美 桜井 弘
出版者
公益社団法人 日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.77, no.10, pp.571-576, 2003-10-25 (Released:2017-12-26)
参考文献数
26
被引用文献数
1

Insuhnomimetic activities of Zn(II) complexes (ZnCl(Vc) and Zn(Vc)_2) with vitamin C (VcH) were found in isolated rat adipocytes treated with epinephrme in terms of inhibition of free fatty acid release. Furthermore, the improvement of glucose tolerance for KK-A^y mice model with type 2 diabetes melhtus was observed when ZnCl(Vc) was orally administered for 4 weeks
著者
青山 みさ子 四童子 好廣 山口 義彦 貞森 直樹
出版者
公益社団法人 日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.82, no.3, pp.179-185, 2008
参考文献数
11

Single-nucleotide polymorphisms (SNPs) of the mitochondrial NADH dehydrogenase subunit-2 (ND2) andβ3-adrenergic receptor (BAR3) genes are well established to be associated with life style-related diseases. The ND2 gene variant (Mt5178A) is associated with longevity or less susceptibility to adult-onset diseases. The BAR3 gene allelic variant (Trp64Arg and Arg64Arg) is linked with obesity or non-insulin-dependent diabetes mellitus. We investigated whether the combination of these 2 genes affect eating behavior, and found that the BAR3-normal (Trp64Trp)+ND2-variant (Mt5178A) group preferred much carbohydrate and less animal protein, Vitamin B_2 (B_<2)>, calcium in comparison with the other genetic groups. Less intake of B_2 was principally associated with Mt5178A in this group. Taking account that flavin adenine dinucleotide is a coenzyme of the NADH dehydrogenase which composes the proton-pumping complex I of the mitochondrial electron transport system, the association between Mt5178A variant and less B_2 intake is tremendously interesting. In this paper, we discuss a possible association between genetic polymorphism and eating behavior by summarizing our own research data.
著者
美濃 眞
出版者
公益社団法人 日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.74, no.10, pp.501-515, 2000-10-25 (Released:2017-12-26)
参考文献数
29
被引用文献数
4

現在, 臨床検査企業の数社でビタミンの測定が行われているが, 測定ビタミン値に関しては精度管理機構もなく, また各社の測定法の実態も不明である. したがって, 依頼者に報告されるビタミンの測定値の信頼性もまったく企業各社に依存した状態であるので, それらのビタミン測定値の正確さと信頼性を確立して貰うために, 日本ビタミン学会では本学会において臨床検体の測定にかかわっている, 各ビタミンの研究者による臨床検査検体試料のビタミン測定法を掲載することとした.