著者

岡田 満 吉岡 加寿夫 磯川 貞之 竹村 司 木下 智弘 赤野 則久 牧 淳

出版者

社団法人 日本腎臓学会

雑誌

日本腎臓学会誌 (ISSN:03852385)

巻号頁・発行日

vol.34, no.11, pp.1195-1199, 1992

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This paper describes a case report of acute interstitial nephritis associated with Bufferin(R). A 15-year-old girl were referred to our hospital due to fever and renal dysfunction. Laboratory findings showed elevation of serum BUN and creatinine, and increased urinary β2-MG excreation. Light microscopic findings of her renal biopsy specimen revealed edema and numerous inflammatory cells in the interstitium, and minor alterations in glomeruli. The interstitial infiltrates consisted mainly of T cells and also monocytes/macrophages. Interstitial cells were labelled with antibodies to interleukin (IL)-1 and tumor necrose factor (TNF). Bufferin(R) was positive by lymphocyte stimulation test . Thus, we considered that this drug was causative in this case. This observation suggests the participation of cell -mediated immune injury in drug induced acute interstitial nephritis .