著者

神作 愛 今井 崇雄 高橋 一郎 澤田 茂樹 山内 美智子 長谷川 英美 石井 和浩 米重 成人

出版者

Japanese Society of Psychosomatic Dentistry

雑誌

日本歯科心身医学会雑誌 (ISSN:09136681)

巻号頁・発行日

vol.12, no.1, pp.29-35, 1997-06-25 (Released:2011-09-20)

参考文献数

15

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The effects of the traditional Chinese (Kampo) medicines, Hochu-ekki-to, Yoku-kansan and Saiko-ka-ryukotsu-borei-to, were compared to those of imipramine, a tricyclic antidepressant, in a mouse model of despair. Mice were placed in a water tank, from which there was no escape, for 15 min. The tank contained a water-wheel and the number of wheel rotations counted as escape attempts and, in accord with previous reports, imipramine (10 mg/kg i.p.), given either acutely or daily for 3 days 10 min before testing, markedly increased the number of wheel rotations. The Kampo medicines were administered for 14 consecutive days in the drinking water prior to testing. Hochu-ekki-to (60, 150 and 300 mg/kg/day) also increased wheel rotations but the effect was not dose-dependent. Yoku-kan-san markedly increased the number of wheel rotations at lower doses (60, 150 mg/kg/day), but decreased the number at the highest dose (300 mg/kg/day). Saiko-ka-ryukotsu-borei-to also increased the number of wheel rotations at the lowest dose (60 mg/kg/day), but decreased the number of rotations at higher doses (150, 300 mg/kg/day). These results suggest that these Kampo medicines, like imipramine, may ameliorate despair in mice.

著者

神作 愛 今井 崇雄 高橋 一郎 澤田 茂樹 山内 美智子 長谷川 英美 五十川 光俊 米重 成人

出版者

Japanese Society of Psychosomatic Dentistry

雑誌

日本歯科心身医学会雑誌 (ISSN:09136681)

巻号頁・発行日

vol.12, no.1, pp.37-41, 1997-06-25 (Released:2011-09-20)

参考文献数

12

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Antinociceptive effects of the traditional Chinese (Kampo) medicines, Hochu-ekki-to, Yoku-kan-san and Saiko-ka-ryukotsu-borei-to, were studied on acetic acid-induced writhing in mice. The number of writhings observed was counted in consecutive 5 min periods for 60 min after intraperitoneal injection of 0.6% acetic acid. Kampo medicines were administered for 14 consecutive days, prior to testing, in the drinking water. Oral administration of Hochu-ekki-to (60, 150 and 300 mg/kg/day) dose-dependently reduced the number of acetic acid-induced writhings. Yoku-kan-san (60, 150 and 300mg/kg/day) tended to inhibit the writhing response to acetic acid in a dose-related manner. Saiko-ka-ryukotsu-borei-to (60, 150 and 300 mg/kg/day) markedly reduced the number of acetic acid-induced writhings but its effects were not dose-dependent. These results suggest that these Kampo medicines may have antinociceptive properties.