著者

奥山 治美 笠本 進一 浜崎 智仁

出版者

日本脂質栄養学会

雑誌

脂質栄養学 (ISSN:13434594)

巻号頁・発行日

vol.27, no.1, pp.21-29, 2018-03-31 (Released:2018-07-16)

---

The Japan Atherosclerosis Society Guidelines for the Prevention of Atherosclerotic Cardiovascular Diseases (JASGL) were based on “the lower, the better” hypothesis. However, we published Cholesterol Guidelines for Longevity 2010 based on the fact that cholesterol levels are inversely associated with all-cause mortality among general populations aged at 40 years and over. Here, we summarized the mechanisms of atherogenesis caused by statins and some types of vegetable oils with strokestimulating activity in the rat; they inhibit the VK1-VK2- osteocalcin target organs link, leading to artery calcification and lifestyle-related diseases. The mainstay of JASGL 2017 is the Suita study published in 2014, which is much smaller than the previous epidemiological study, NIPPONDATA 80, for JASGL 2012. Besides, the total and cardiovascular mortality of the study has not been published yet. We found some terrible mathematical errors that cannot be simple calculation mistakes. For example, deleting some study subjects actually increased the number of male participants instead. It is likely that no consistent epidemiological studies are available any more to JAS to protect their cholesterol hypothesis. JASGL 2017 calculated risk of coronary artery disease (CAD) in Japan where the incidence is very low. Then the story was fabricated to protect their notion that even the group with a very low risk in the world standard was classified as middle to high risk groups of CAD, which can lead to unnecessary medication. The GLs are disguised as those based on the cholesterol hypothesis; actually it became very clear that they are simply selling tools for statins.