著者

金澤 裕太 野地 なつ美 齊藤 隆夫 吉田 茂男 浅見 忠男

出版者

一般社団法人 植物化学調節学会

雑誌

植物化学調節学会 研究発表記録集 (ISSN:09191887)

巻号頁・発行日

vol.39, pp.90, 2004-10-13 (Released:2018-02-15)

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Pyrroloquinoline quinone(PQQ; 1) was discovered as a novel co-factor in various bacterial alcohol dehydrogenases in 1979. In 2003, it was reported that PQQ is nutritionally important as a vitamin in mammals. Various analytical methods have been reported for the quantification of free PQQ, but their reports have not established a detailed procedure for the assay of PQQ in crude biological samples. In this study, we have synthesized ^<13>C-labeled PQQ to use this chemical as an internal standard. We synthesized the labeled PQQ from 5-amino-2-methoxyformanilide(2) by applying Corey's method in a key step.