著者

阿部 俊克 大塚 勝弘 大熊 誠一

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.101, no.1, pp.78-81, 1981-01-25

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Rice bran lectin (RBL) agglutinated human erythrocytes regardless of their ABO and MN blood-group systems. The receptor activity of erythrocytes against RBL was completely abolished by treatment with pronase for two hours and partially abolished by treatment with trypsin or α-chymotrypsin for three hours. Sialoglycopeptides released from human erythrocytes by treatment with protease such as pronase, trypsin or α-chymotrypsin inhibited the hemagglutination by RBL. Removal of sialic acid residues of sialoglycopeptides diminished their inhibitory activities. Among sugars tested, only N-acetyl-D-glucosamine showed hemagglutinating inhibition.