著者

福島 昭治 今井田 克己 萩原 昭裕 香川 雅孝 荒井 昌之

出版者

JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

雑誌

Journal of Toxicologic Pathology (ISSN:09149198)

巻号頁・発行日

vol.1, no.1, pp.25-32, 1988-05-31 (Released:2009-01-22)

参考文献数

23

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Dose-response studies on early lesions and carcinogenesis of urinary bladder were carried out in male rats treated with N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN). In experiment 1, BBN was given in 6 different concentrations as solutions in drinking water to examine early lesions of the urinary bladder to F344, 6-week-old rats for up to 12 weeks. Doses of more than 0.01% BBN induced histologically simple hyperplasia and papillary or nodular hyperplasia, and scanning electron microscopically pleomorphic microvilli, short, uniform microvilli, and ropy or leafy microridges. 0.005% BBN treatment also induced ropy or leafy microridges. In experiment 2, BBN was given in 3 different doses to Wistar, 8-week-old rats for up to 82 weeks. The highest dose, 0.005% induced urinary bladder carcinoma and the lowest dose, 0.0005% did not develop any changes of the urinary bladder.