著者

久保寺 昭子 毛利 哲郎 鶴藤 丞

出版者

公益社団法人日本薬学会

雑誌

薬学雑誌 (ISSN:00316903)

巻号頁・発行日

vol.87, no.5, pp.511-515, 1967-05

---

Effect of 10 chelating agents on the excretion of radiostrontium from the body was investigated in mice. Sodium salts and/or monocalcium-sodium salts of these chelating agents were used as test materials. Preliminery toxicity tests were carried out to estimate their approximate maximum safety doses. The sodium salts were generally more toxic and brought about some convulsion with occasional death which were attributed to the decrease of Ca^<2+> ion in the blood. The monocalcium-sodium salts were applicable in 10-folds as compared with their equivalent sodium salts. The chelating agents and radioactive strontium were simultaneously injected into different parts of the body. The animals were killed 24 hours after the injection, and then reduced to ashes individually in an electric furnace after removing the digestive tracts and bladders. Radioactivity of the ashes was assayed to determine the percentage retention of radioactive strontium in the carcasses. Monocalcium-disodium salt of bis(dicarboxyaminoethyl) ether was found to be one of the most effective agents, same as calcium sodium citrate which had been previously reported.