著者

佐々木 結花 山岸 文雄 水谷 文雄 八木 毅典 黒田 文伸 和田 暁彦

出版者

JAPANESE SOCIETY FOR TUBERCULOSIS

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.74, no.7, pp.549-553, 1999-07-15 (Released:2011-05-24)

参考文献数

11

被引用文献数

1

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We experienced a small outbreak of multidrug-resistant Mycobacterium tuberculosis infection (MDR-TB) among persons of in the middle and advanced age. The index case was 48-year-old man, and had complained productive cough since January 1996. He visited a doctor due to his symptom, and chest X-ray revealed cavitary lesion and sputum smear was positive for tubercle bacilli. He could not continue his admission because of his absence without leave and drinking, he was discharged on Day 54. The drug resistance was observed for INH (0.1μg/ml), RFP, and SM.Later, case 2, 52-year-old male, and case 3, 43-year-old-male, who were companions in mah-jongg with the index case, were diagnosed as pulmonary tuberculosis. The analysis of restriction fragment length polymorphism (RFLP) was done on 3 strains, and all showed the same pattern. Among other companions in mah-jongg with the index case, case 4, 28-year-old male, was treated as MDR-TB, and the drug resistance pattern was the same to that of the index case, but the details were unknown. Case 5, 65-year-old male, was diagnosed as drug sensitive pulmonary tuberculosis, thus he might incidentally suffer from pulmonary tuberculosis at the same time. Case 6, 46-year-old male, who had been treated for alcoholic liver cirrhosis, was introduced to our hospital as his sputum smear was positive, and the drug resistance pattern was observed similar to that of the index case.All the companions in mah-jongg suffered from MDR-TB except case 5. The RFLP analysis showed that the index case, case 2, and case 3 were caused by the same strain of M. tuberculosis. The drug resistance pattern of, case 4 and case 6 was the same to that of the index case. Based on these findings, it is highly suspected that this small outbreak was originated from the index case.

著者

佐々木 結花 山岸 文雄 八木 毅典 山谷 英樹 黒田 文伸 庄田 英明

出版者

JAPANESE SOCIETY FOR TUBERCULOSIS

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.77, no.6, pp.443-448, 2002-06-15

被引用文献数

3

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広汎空洞型肺結核 (<I>b</I>I3) 症例を臨床的に検討した。対象は95例, 平均年齢は49.5±13.0歳であった。結核発見動機は, 有症状受診84例, 他疾患管理中10例, 他疾患受診時偶然発見1例で, 全例が喀痰塗抹陽性であった。社会背景として職業は入院時無職31例, 日雇労務者24例, 生活保護受給者25例と, 社会的弱者が多数であった。入院時病状として重症例が多数であり栄養状態は不良であった。当院入院中に死亡した症例は19例 (20.0%) で全例男性であり, 結核発見動機は全例有症状受診で, 入院から死亡までの期間 (在院日数) は35.0±39.8日と短期であった。有症状受診例84例の受診の遅れの期間は5.5±5.0カ月であり診断の遅れの期間は0.3±0.9カ月と短期間であった。<I>b</I>I3症例は発見の遅れの長期化により重症化し, 受診の遅れがその大部分を占めた。予後不良であるこの病型が生じないために発見の遅れを短期化するよう多様な予防対策の実施が望まれる。