- 著者
- Hiroto MAEDA Kazuyuki SOGAWA Kazuko SAKAGUCHI Saori ABE Wataru SAGIZAKA Shunsuke MOCHIZUKI Waka HORIE Toshifumi WATANABE Yui SHIBATA Mamoru SATOH Akihiro SANDA Fumio NOMURA Jun SUZUKI
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.14-0427, (Released:2015-03-28)
- 被引用文献数
- 2 20
Feline renal diseases are increasingly noted in veterinary practice. It is important to diagnose and identify the pathological basis of renal dysfunction accurately at an early stage, but there are only a few reports on this area in clinical veterinary medicine. We investigated the efficacy of measurement of urinary albumin (u-Alb) and urinary transferrin (u-Tf) for early diagnosis using 5-µl urine samples collected noninvasively by catheterization from normal (IRIS stage I) cats and cats with stage I chronic kidney disease (CKD). The u-Alb levels in normal and stage I CKD cats were 6.0 ± 4.5 and 11.2 ± 8.4 mg/dl, respectively, and the u-Tf levels were 0.09 ± 0.42 and 0.52 ± 0.79 mg/dl, respectively. Based on ROC curve analysis, the sensitivity and specificity of u-Alb and u-Tf were higher than those of the currently used biomarker, the plasma creatinine level. The sensitivity of u-Alb was higher than that of u-Tf, whereas the specificity of u-Tf was higher than that of u-Alb. The validity of the threshold albumin level (20 mg/dl) was confirmed by measurements using SDS-PAGE. Since leakage of u-Tf in urine precedes leakage of u-Alb, inclusion of u-Tf in biochemistry tests may be appropriate for IRIS staging as a diagnostic marker of early diagnosis of renal disorder in cats.
- 著者
- KAZUYUKI SOGAWA MIKA KOBAYASHI JUN SUZUKI AKIHIRO SANDA YOSHIO KODERA MASAFUMI FUKUYAMA
- 出版者
- The Society for Antibacterial and Antifungal Agents, Japan
- 雑誌
- Biocontrol Science (ISSN:13424815)
- 巻号頁・発行日
- vol.23, no.2, pp.77-80, 2018 (Released:2018-06-16)
- 参考文献数
- 19
- 被引用文献数
- 2 4
Group A streptococcus is a bacterium that resides in the throat and skin and causes respiratory infection and occasionally glomerulonephritis and rheumatic fever. Streptolysin O (SLO) produced by Streptococcus pyogenes (S. pyogenes) binds to the cell membrane, particularly to that of white and red blood cells, and is toxic to the cells and tissue. In this study, we evaluated the inhibitory activity of water-soluble polyphenols in olives (Olea europaea) against SLO-induced hemolysis. Hydroxytyrosol inhibited SLO-induced hemolytic activity, and the amount required for 50% inhibition of hemolysis was 1.30 µg. These findings suggest that the water-soluble polyphenols contained in olives have inhibitory activity against SLO-induced hemolysis.