著者
Keitaro OHMORI Kenichi MASUDA Masahiro SAKAGUCHI Yukiko KABURAGI Koichi OHNO Hajime TSUJIMOTO
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.64, no.9, pp.851-853, 2002 (Released:2002-10-04)
参考文献数
13
被引用文献数
6 10

Adverse reactions to vaccines were examined in 311 canine cases reported to the Ministry of Agriculture, Forestry and Fisheries in Japan during the period of 6 years from April of 1994 to March of 2000, and classified according to their clinical symptoms. There were 27 cases of adverse reactions to rabies virus vaccines. Gastrointestinal symptoms were the most frequently observed (26%), followed by respiratory and/or cardiovascular symptoms (22%) and dermatologic symptoms (11%). There were 284 cases of adverse reactions to non-rabies monovalent vaccines and mixed vaccines. Dermatologic symptoms were the most frequently observed (53%), followed by gastrointestinal symptoms (16%) and respiratory and/or cardiovascular symptoms (14%). Of the total 311 cases, 11 (3.5%) died of adverse reactions to vaccines.
著者
大森 啓太郎 増田 健一 阪口 雅弘 蕪木 由紀子 大野 耕一 辻本 元
出版者
社団法人日本獣医学会
雑誌
The journal of veterinary medical science (ISSN:09167250)
巻号頁・発行日
vol.64, no.9, pp.851-853, 2002-09-25
参考文献数
13

農林水産省に犬のワクチン副反応として報告された311症例を症状別に分類した.狂犬病ワクチンにより副反応を起こした27症例においては消化器症状が最も多く(26%),次いで呼吸・循環器症状(22%),皮膚症状(11%)であった.狂犬病ワクチン以外の単価,混合ワクチンにより副反応を起こした284症例においては,皮膚症状が最も多く(53%),次いで消化器症状(16%),呼吸・循環器症状(14%)であった.311症例中,11症例(3.5%)においてワクチン副反応による死亡が認められた.
著者
Morihiro TATENO Masashi TAKAHASHI Eri MIYAKE Kazuo NISHIGAKI Hajime TSUJIMOTO Yasuyuki ENDO
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.17-0039, (Released:2017-08-25)
被引用文献数
10

Gammaherpesviruses (GHVs) are members of an emerging subfamily of the family Herpesviridae. A recent study identified a novel GHV in domestic cats (Felis catus GHV1, FcaGHV1), and epidemiological surveys have found that FcaGHV1 is distributed worldwide. In this study, we investigated the prevalence of GHVs in domestic cats in Japan with a molecular epidemiological survey. Blood samples were collected from 1,738 domestic cats and GHV-derived DNA was detected with PCR in 1.3% (23/1,738) of the Japanese domestic cats. The FcaGHV1 detected in this study was very similar to FcaGHV1 detected in a domestic cat in North America. Older age (>5 years old) and Feline immunodeficiency virus infection were identified as risk factors for GHV infection.
著者
Keiko ITO Shintaro ABE Ryo YAMASHITA Daisuke SUMIYAMA Tomoko KANAZAWA Koichi MURATA
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.82, no.2, pp.229-231, 2020 (Released:2020-02-18)
参考文献数
22

Prevalence of antibodies to Toxoplasm gondii was studied using the latex agglutination (LA) method, followed by sucrose density gradient centrifugation (SDGC) method on the small Indian mongoose (Herpestes auropunctatus), which inhabits Amami-Oshima Island. Of the 362 samples, 38 (10.5%) revealed positive. Single or double peaks in the 7–8 and/or 12–14 fraction to LA titer by SDGC indicated the early stage of T. gondii infection. It is suggested that domestic/feral cats play an important role for spreading this zoonotic pathogen to the mongoose as well as other species that are endemic to this island. Future studies are warranted to prevent the transmission of T. gondii among cats and wild animals in order to maintain the ecosystem health.
著者
Daisuke SUMIYAMA Ayako SHIMIZU Tomoko KANAZAWA Hiroshi ANZAI Koichi MURATA
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.19-0594, (Released:2020-03-24)

Here, we investigated the prevalence of Salmonellaenterica, with and without resistance to 17 common antimicrobial agents, in 706 green anoles (Anolis carolinensis) that were collected in Naha and Tomishiro Cities, Okinawa Main Island, Japan, between 2009 and 2014. Salmonella strains, including S. enterica Weltevreden and Enteritidis serovars, were identified in the large intestinal content samples extracted from 15 (2.1%) of the analyzed green anoles. No antimicrobial resistance was detected. Thus, the present study demonstrates that although the prevalence of Salmonella and the risk of its transmission from the green anoles to humans or other animals on Okinawa Main Island are relatively low, the green anole population nevertheless represents a potential source of Salmonella infection that could affect human health in this region.
著者
Ken-ichiro KAMEYAMA Tatsuya NISHI Manabu YAMADA Kentaro MASUJIN Kazuki MORIOKA Takehiro KOKUHO Katsuhiko FUKAI
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.19-0133, (Released:2019-07-09)
被引用文献数
9

Following an outbreak of classical swine fever (CSF) in Japan, 2018, CSFV JPN/1/2018 was isolated from an infected pig sample. In this study, we carried out a comparative experimental infection in pigs using this strain and the highly virulent ALD strain and compared outcomes, including clinical manifestation, virus shedding patterns and antibody responses. Although pigs inoculated orally or intramuscularly with JPN/1/2018 developed hyperthermia and had decreased leucocyte numbers, they survived for the whole experimental period and showed less severe clinical signs than those infected with the ALD strain. We confirmed the presence of characteristic multifocal infarction of the margin of the spleen that arises following infection with JPN/1/2018, albeit that this finding was not observed in all infected pigs. Both viruses efficiently spread to contact pigs in a similar manner, suggesting in transmissibility between the two strains. Viral RNAs were detected in all clinical samples, especially whole blood samples, before the pigs developed hyperthermia until at least approximately 2 weeks after inoculation. Our findings will be valuable for the investigations into epidemic events occurring in Japan and for establishing diagnostic strategies and control measures against CSF.
著者
Toshiro YAMAGUCHI Kaita SAWANO Kazuhisa FURUHAMA Chizuo MORI Kazutaka YAMADA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.12-0296, (Released:2012-08-28)
被引用文献数
2 4

We utilized autoradiography to visualize radioactive contamination in the skeletal muscles of a pig raised within 20 km of the Fukushima Daiichi nuclear power plant following the nuclear accident. The autoradiogram of control muscle showed relatively homogenous exposure. In contrast, the autoradiogram of affected muscle showed a heterogeneous and sporadically dense imaging pattern. Photo luminescence densities of the affected and control muscles were 3.89 ± 0.67 and 2.13 ± 0.43 PSL/mm2, respectively. This difference indicated that radioactive cesium was distributed in the skeletal muscle of the affected pig.
著者
野村 紘一
出版者
社団法人日本獣医学会
雑誌
The journal of veterinary medical science (ISSN:09167250)
巻号頁・発行日
vol.57, no.1, pp.71-74, 1995-02-15
被引用文献数
5

着床期の犬子宮内膜に人工的刺激を加えると, 脱落膜反応が誘起できることを先の報告で明らかにしたが, これらの組織反応は刺激の種類によって相違した. 本報告では,オリーブオイルを刺激源にしたときの組織反応の特徴を明らかにする目的でオリーブオイル注入のみの場合と創傷刺激後に注入した場合の組織像を比較検討した. 前者の場合は,子宮内膜上皮は網状あるいは樹枝状に子宮内腔に向け増殖したが, 機能層並びに基底層子宮腺の豪胞状過形成は起こらなかった. これに対して後者の場合は子宮内膜上皮の増殖以外に創傷性損傷を受けたと思われる箇所を中心にして基底腺の嚢胞状拡張増殖が付加され, いわゆるスイスチーズ様内膜を示した. オリーブオイルのみの刺激で子宮内膜上皮並びに緻密層子宮腺の子宮内腔へ向けての増殖を誘発することができるが, 機能層や基底層の子宮腺の増殖拡張を引き起こすには子宮腺の開口部の損傷が必要である.
著者
Atsushi KOBAYASHI Sayaka TSUCHIDA Atsushi UEDA Takuji YAMADA Koichi MURATA Hiroshi NAKAMURA Kazunari USHIDA
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.19-0014, (Released:2019-08-12)
被引用文献数
1

The transgenerational maintenance of symbiotic microbes that benefit host nutrition and health is evolutionarily advantageous. In some vertebrate lineages, coprophagy is used as a strategy for effectively transmitting microbes across generations. However, this strategy has still not been studied in birds. Accordingly, the aim of the present study was to evaluate the role of maternal cecal feces consumption by Japanese rock ptarmigan (Lagopus muta japonica) chicks as a strategy for acquiring essential gut microbes. Both the duration of coprophagy behavior by the chicks and the development process of the chick cecal microbiome (n=20 one- to three-week-old chicks, from three broods) were investigated. In all three broods, coprophagy behavior was only observed from 3 to 18 days of age. Furthermore, there was no significant difference in the number of bacterial operational taxonomic units (OTUs) in 1-week-old chicks (n=651) and adults (n=609), and most of the main OTUs observed in the adults were already present in the 1-week-old chicks. These results indicate that, in this precocial bird species, coprophagy may contribute to the early establishment of cecal bacteria that are essential for food digestion and, thus, chick survival. In fact, Japanese rock ptarmigan chicks consume the same food as their hens from the time of hatching. This behavior may have applications to ex-situ conservation.
著者
Tsutomu OMATSU Miki OMURA Yukie KATAYAMA Toru KIMURA Maho OKUMURA Atsushi OKUMURA Yoshiteru MURATA Tetsuya MIZUTANI
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.17-0582, (Released:2018-04-11)
被引用文献数
10

The intestinal microbiota was revealed with the recent advances in molecular techniques, such as high-throughput sequencing analysis. As a result, the microbial changes are thought to influence the health of humans and animals and such changes are affected by several factors including diet, genetics, age, sex, and diseases. Similar studies are being conducted in dogs, and the knowledge of intestinal microbiota in dogs is expanding. Nonetheless, basic information on intestinal microbiota in dogs is less than that of humans. Our aim was to study toy poodles (n=21), a popular companion dog, in terms of basic characteristics of the faecal microbiota by 16S rRNA gene barcoding analysis. In the faecal microbiota, Firmicutes, Bacteroidetes, Proteobacteria, and Fusobacteria were the dominant phyla (over 93.4% of faecal microbiota) regardless of the attributes of the dogs. In family level, Enterobacteriaceae, Bacteroidaceae, and Lachnospiraceae were most prevalent. In case of a dog with protein-losing enteropathy, the diversity of faecal microbiota was different between before and after treatment. This study provides basic information for studying on faecal microbiota in toy poodles.
著者
Aya MATSUU Shin-ichi YOKOTA Keiko ITO Tatsunori MASATANI
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.79, no.11, pp.1853-1856, 2017 (Released:2017-11-17)
参考文献数
11
被引用文献数
3

On Amami Oshima Island, free-ranging and feral cats are harmful to wildlife populations. In this study, the seroprevalence of Toxoplasma gondii in these cats was examined using a newly developed Gaussia luciferase immunoprecipitation system assay. Of 1,363 cats, 123 cats (9.0%) was positive for T. gondii. The prevalence was significantly different in different areas; among cats in the rural area, where many wild animals live, including endangered species, T. gondii infection was more prevalent than in the urban area of the island. This finding indicates a possible risk to wildlife of infection from free-ranging and feral cats. Therefore, management of cats is important for wildlife conservation.
著者
Satoru TERAI Hideki ENDO Worawut RERKAMNUAYCHOKE Eiichi HONDO Srihadi AGUNGPRIYONO Nobuo KITAMURA Masamichi KUROHMARU Junpei KIMURA Yoshihiro HAYASHI Takao NISHIDA Junzo YAMADA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.60, no.10, pp.1097-1105, 1998 (Released:2001-10-06)
参考文献数
15
被引用文献数
6 8

The lesser mouse deer (Tragulus javanicus) is one of the most primitive ruminants. Skulls of lesser mouse deer were measured to evaluate their growth. The age was estimated from the eruption and attrition of molars on the mandible. A total of 95 specimens was divided into five age groups, and the growth pattern in each sex was established for some measurements. The relative growth coefficients were calculated for the head and body length and several parts of the cranium and mandible against the profile length. Sexual dimorphism could not be found on the skull in any age group except for measurements related to the upper canine. However, females showed a higher value in head and body length in the oldest group. This feature was consistent with an interpretation of mouse deer society as monogamous. Growth was more rapid in length than in width. Various statistical analyses showed that the visceral cranium related to masticatory facility was much better developed than the neurocranium. However, observations on the shape of the mandible ramus and of the premolars implied that the masticatory function was not suitable for taking roughage. This speculation agreed with previous reports on the feeding habits and digestive organs of the mouse deer.
著者
Atsushi KOBAYASHI Sayaka TSUCHIDA Takanari HATTORI Koretsugu OGATA Atsushi UEDA Takuji YAMADA Koichi MURATA Hiroshi NAKAMURA Kazunari USHIDA
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.20-0003, (Released:2020-06-23)

Ex situ conservation of Japanese rock ptarmigans began in 2015 with the aim of reintroducing artificially raised birds into their original habitat. However, the current raising method in captivity seems insufficient in terms of the survivability of artificially raised birds in natural conditions. Feeding management is one potential reason for such insufficiency. In this study, we performed a comprehensive analysis of the hydrophilic metabolites by LC-MS/MS for the cecal feces of Japanese rock ptarmigans under in situ and ex situ conservation to reveal their gut chemical environment. We also analyzed the developmental processes of cecal microbiomes both in situ semi-wild and ex situ captive individuals. Metabolites of nucleic acid were rich in the in situ individuals, and free amino acids were rich in the ex situ individuals. The differences in the microbiome composition between in situ and ex situ individuals were also pronounced; major genera of in situ individuals were not detected or few in ex situ individuals. The alpha diversity of the cecal microbiome of semi-wild chicks at 1 week of age was almost the same as that of their hens, while it was very low in captive individuals. Sub-therapeutic use of oxytetracycline, a diet rich in protein and energy, and isolation from adult birds are considered to be causes for these great differences in gut chemical and microbiological environment between in situ and ex situ individuals.
著者
Hakimullah HAKIM Chanathip THAMMAKARN Atsushi SUGURO Yuki ISHIDA Akinobu KAWAMURA Miho TAMURA Keisuke SATOH Misato TSUJIMURA Tomomi HASEGAWA Kazuaki TAKEHARA
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.77, no.2, pp.211-215, 2015 (Released:2015-03-01)
参考文献数
32
被引用文献数
14 17

Hypochlorous acid (HOCl) solutions were evaluated for their virucidal ability against a low pathogenic avian influenza virus (AIV), H7N1. HOCl solutions containing 50, 100 and 200 ppm chlorine (pH 6) or their sprayed solutions (harvested in dishes placed at 1 or 30 cm distance between the spray nozzle and dish) were mixed with the virus with or without organic materials (5% fetal bovine serum: FBS). Under plain diluent conditions (without FBS), harvested solutions of HOCl after spraying could decrease the AIV titer by more than 1,000 times, to an undetectable level (< 2.5 log10TCID50/ml) within 5 sec, with the exception of the 50 ppm solution harvested after spraying at the distance of 30 cm. Under the dirty conditions (in the presence of 5% FBS), they lost their virucidal activity. When HOCl solutions were sprayed directly on the virus on rayon sheets for 10 sec, the solutions of 100 and 200 ppm could inactivate AIV immediately after spraying, while 50 ppm solution required at least 3 min of contact time. In the indirect spray form, after 10 sec of spraying, the lids of the dishes were opened to expose the virus on rayon sheets to HOCl. In this form, the 200 ppm solution inactivated AIV within 10 min of contact, while 50 and 100 ppm could not inactivate it. These data suggest that HOCl can be used in spray form to inactivate AIV at the farm level.
著者
Mifumi KAWABE Yuta BABA Reo TAMAI Ryohei YAMAMOTO Masayuki KOMORI Takashi MORI Shigeo TAKENAKA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.14-0641, (Released:2015-04-04)
被引用文献数
1 7

Malignant melanoma is one of the most common and aggressive tumors in the oral cavity of dog. The tumor has a poor prognosis, and methods for diagnosis and prediction of prognosis after treatment are required. Here, we examined metabolite profiling using gas chromatography-mass spectrometry (GC-MS) for development of a discriminant model for evaluation of prognosis. Metabolite profiles were evaluated in healthy and melanoma plasma samples using orthogonal projection to latent structure using discriminant analysis (OPLS-DA). Cases that were predicted to be healthy using the OPLS discriminant model had no advanced lesions after radiation therapy. These results indicate that metabolite profiling may be useful in diagnosis and prediction of prognosis of canine malignant melanoma.
著者
遠藤 秀紀 川嶋 舟 堤 たか雄 佐々木 基樹 山際 大志郎 林 良博
出版者
社団法人日本獣医学会
雑誌
The journal of veterinary medical science (ISSN:09167250)
巻号頁・発行日
vol.61, no.10, pp.1087-1091, s・iii, 1999-10
参考文献数
12
被引用文献数
1 1

350年以上生態学的に隔離された可能性をもつ,皇居産のアズマモグラ集団の形態学的,および分子遺伝学的特質を把握するため,頭骨の骨計測学的検討を進め,ミトコンドリアDNAのチトクロームbおよび12SrRNA遺伝子の塩基配列を明らかにし,他のアズマモグラ集団およびサドモグラと比較した.頭骨の形態において,皇居産は,ほかの関東地区集団と比較して,大きなサイズをもつことが明らかになった.主成分分析においては,皇居集団が,関東地方産アズマモグラの大型タイプとして,ひとつのクラスターをつくる可能性が示された.しかし,これはアズマモグラの種内変異以上の分離ではないことが推測された.一方,皇居集団は,東京都日野市集団との間に,チトクロームb遺伝子の塩基配列においては98.5%,12SrRNA遺伝子では98.7%という高いホモロジーを示した.
著者
Tetsushi HIRANO Shogo YANAI Takuya OMOTEHARA Rie HASHIMOTO Yuria UMEMURA Naoto KUBOTA Kiichi MINAMI Daichi NAGAHARA Eiko MATSUO Yoshiko AIHARA Ryota SHINOHARA Tomoyuki FURUYASHIKI Youhei MANTANI Toshifumi YOKOYAMA Hiroshi KITAGAWA Nobuhiko HOSHI
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.77, no.10, pp.1207-1215, 2015 (Released:2015-11-05)
参考文献数
42
被引用文献数
7 20

Neonicotinoids, some of the most widely used pesticides in the world, act as agonists to the nicotinic acetylcholine receptors (nAChRs) of insects, resulting in death from abnormal excitability. Neonicotinoids unexpectedly became a major topic as a compelling cause of honeybee colony collapse disorder, which is damaging crop production that requires pollination worldwide. Mammal nAChRs appear to have a certain affinity for neonicotinoids with lower levels than those of insects; there is thus rising concern about unpredictable adverse effects of neonicotinoids on vertebrates. We hypothesized that the effects of neonicotinoids would be enhanced under a chronic stressed condition, which is known to alter the expression of targets of neonicotinoids, i.e., neuronal nAChRs. We performed immunohistochemical and behavioral analyses in male mice actively administered a neonicotinoid, clothianidin (CTD; 0, 10, 50 and 250 mg/kg/day), for 4 weeks under an unpredictable chronic stress procedure. Vacuolated seminiferous epithelia and a decrease in the immunoreactivity of the antioxidant enzyme glutathione peroxidase 4 were observed in the testes of the CTD+stress mice. In an open field test, although the locomotor activities were not affected, the anxiety-like behaviors of the mice were elevated by both CTD and stress. The present study demonstrates that the behavioral and reproductive effects of CTD become more serious in combination with environmental stress, which may reflect our actual situation of multiple exposure.
著者
Maika FUJITA Masahiro KANEDA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.17-0179, (Released:2017-06-24)
被引用文献数
1

DNA methylation is an epigenetic mechanism controlling gene expression without affecting DNA sequences, and aberrant DNA methylation patterns are features of a number of diseases. Notably, epigenetic errors in cancer cells have been intensively studied over the last two decades in humans; however, little is known concerning dogs and cats. To analyze DNA methylation and gene expression changes in feline lymphoma cells, we added the DNA methylation inhibitor 5-aza-2′-deoxycytidine (5-aza) to three cell lines (3281 and FT-1 cells derived from T-cell lymphoma and MS4 cells derived from B-cell lymphoma). Adding 5-aza significantly retarded cell growth in a dose-dependent manner in all cell lines, and there were aberrant gene expression patterns. Transcription factor Sox11 expression in 3281 cells was de-repressed by 5-aza treatment, and subsequent promoter DNA demethylation was analyzed by bisulfite sequencing. Cell cycle analysis suggested that inhibition of cell growth was due to DNA replication arrest, and this supported the result of increased expression of p27kip1 gene which disturbed cells of 3281 and FT-1 entering the S phase. In this study, 5-aza suppressed the growth of feline lymphoma cells, but further experiments with normal lymph cells are necessary to confirm specificity of this drug treatment and to expand it for clinical use.
著者
Masashi TAKAHASHI Hirotaka TOMIYASU Eri HOTTA Hajime ASADA Kenjiro FUKUSHIMA Hideyuki KANEMOTO Yasuhito FUJINO Koichi OHNO Kazuyuki UCHIDA Hiroyuki NAKAYAMA Hajime TSUJIMOTO
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.13-0414, (Released:2014-01-20)
被引用文献数
6 24

Canine histiocytic sarcoma (HS) is a rare neoplasm that originates from dendritic cells or macrophages, and there have been a number of cases experienced in Japan. To identify the characteristics and prognostic variables that determine outcome in dogs with HS in Japan, medical records of 73 dogs with HS were retrospectively analyzed. Signalment, clinical signs, complete blood count (CBC), blood chemistry profiles, treatment, response to treatment and overall survival (OS) were analyzed. Diagnosis of HS was determined histologically in 44 cases and cytologically in 29 cases. The most frequently diagnosed breeds were Flat-Coated Retrievers (n=16, odds ratio [OR] 62.0), Pembroke Welsh corgis (n=15, OR 9.7) and Bernese Mountain dogs (n=14, OR 45.0). Median survival time for all dogs in this study was 43 days. In the dogs that received no treatment or only symptomatic treatment, the median OS was 12 days (range 2–254 days) compared with that of dogs that received surgical treatment and/or chemotherapy (85 days, range 4–360 days). Univariate analysis identified anemia, thrombocytopenia, hypoalbuminemia, hypoproteinemia and not receiving antitumor treatment (chemotherapy and/or surgery) as factors significantly associated with shorter OS. Multivariate analysis confirmed that platelet counts, localized/disseminated lesional pattern and whether the dog received antitumor treatment were significantly predictive of survival.
著者
Yuya KIMURA Hidenobu KAWABATA Masaji MAEZAWA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.13-0231, (Released:2013-12-11)
被引用文献数
3

Some individuals manifest psychosomatic symptoms after the death of their pets. A survey was conducted at four public and commercial animal cremation service centers in Japan. In each center, a questionnaire was distributed to 100 individuals (400 in total). The questionnaire consisted of the 28-item version of the General Health Questionnaire (GHQ28), the social readjustment rating scale (SRRS) and a series of questions regarding demographic information and the circumstances of their pet’s death. In total, 82 returned questionnaires were available for analysis. GHQ28 proved the existence of neurotic symptoms in 46 responses (56.1%; 95% confidence interval: 44.7–67.0%). Analysis of the responses using the GHQ28 subscales with a Likert scoring system demonstrated more somatic dysfunction in females (GHQ-A: P=0.04). Furthermore, significant correlations were identified among the following factors: owner’s age (GHQ-A: P=−0.60, P=0.01; GHQ-B: P=−0.29, P=0.01; GHQ-C: P=−0.32, P<0.01; GHQ-D: P=−0.42, P<0.01), SRRS score (GHQ-A: P=0.32, P<0.01; GHQ-B: P=0.25, P=0.02; GHQ-D: P=0.30, P=0.01) and animal’s age (GHQ-D: P=−0.26, P=0.02). The death of indoor pets caused deeper depression (GHQ-D: P=0.01) than that of outdoor or visiting pets. The results revealed neurotic symptoms in almost half of the pet owners shortly after their pet’s death.