著者

Doina Piciu Andra Piciu Alexandru Irimie

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.1203190691, (Released:2012-03-23)

被引用文献数

7 12

---

The thyroid carcinoma (TC) has an increasing incidence in the last decades and continues to represent the most frequent endocrine tumor. The aim of the study was to analyze the pediatric files of TC from the registry of “Prof. Dr. Ion Chiricuta” Institute of Oncology Cluj-Napoca, Romania (IOCN) and to provide the data related to the impact of nuclear fallout of Chernobyl on this pathology. We studied 72 children with TC treated between 1991 and 2010. The mean age was 15.3 years; the ratio female/male was 6.2:1. A number of 29 children (40.2%) revealed metastasis in regional lymph nodes or lungs at the initial diagnosis. There were 63 differentiated thyroid carcinoma (DTC), 6 cases with medullary cancer (MC), 1 case with anaplazic carcinoma (AC), and 2 mixed cases. All patients underwent total thyroidectomy and the radioiodine was administered in 64 cases (activities between 1.1 - 28.1 GBq I-131). A number of 52 children (80.5%) are free of disease, 8 are in partial remission and 4 children are in evolution of the disease at minimum 12 months of follow-up. The incidence of TC was significantly increased at 10 years after the accident. In the years after, the increasing trendline was stopped and at 25 years, the number of cases is stationary. The diagnostic of pediatric TC is made frequently in metastatic disease and the therapies must be conducted for many years untill complete remission. A more clear strategy adapted to children is needed in the future.