著者

Tomoko Nakao Atsushi Yasumoto Suzumi Tokuoka Yoshihiro Kita Takuya Kawahara Masao Daimon Yutaka Yatomi

出版者

Japan Society for Occupational Health

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.60, no.4, pp.324-332, 2018-07-20 (Released:2018-07-25)

参考文献数

39

被引用文献数

9

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Objectives: Rotating shift work has been reported to increase the risk of cardiovascular diseases. Vascular endothelial dysfunction and platelet activation are among the leading causes of thrombus formation in patients with myocardial infarction or stroke. Endothelial function has been shown to be impaired immediately after night-shift work; however, it is not known whether platelets are also activated. The aim of this study was to investigate the acute impact of night-shift work on platelet function. Methods: This observational study included 11 healthy medical staff members (seven women, median age 32 years). We examined each subject's platelet aggregation rates and the serum concentrations of eicosanoid mediators after night-shift work and on day-shift work without preceding night-shift work (baseline). Results: Platelet aggregation did not differ from baseline levels after night-shift work. However, serum cyclooxygenase (COX)-metabolized eicosanoid mediators, particularly thromboxane (Tx) B2 (a stable metabolite of TxA2 and the most important marker of platelet activation), were significantly higher after the night-shift than at baseline (median 65.3 vs 180.4 ng/ml). Conclusions: Although platelet aggregation did not increase, there was an increase in serum COX-metabolized eicosanoid mediators such as TxB2 in healthy medical staff after night-shift work. This platelet hypersensitivity may be one of the mechanisms underlying the significant association between night-shift work and adverse cardiovascular outcomes.

著者

Kenta YOSHIDA Tatsu KUWATANI Atsushi YASUMOTO Satoru HARAGUCHI Kenta UEKI Hikaru IWAMORI

出版者

Japan Association of Mineralogical Sciences

雑誌

Journal of Mineralogical and Petrological Sciences (ISSN:13456296)

巻号頁・発行日

pp.171127, (Released:2018-06-07)

被引用文献数

3

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Conventional clustering algorithms such as k–means and fuzzy c–means (FCM) cluster analysis do not fully utilize the spatial distribution information of geologic samples. In this paper, we propose GEOFCM, a new clustering method for geochemical datasets with location coordinates. A spatial FCM algorithm originally constructed for image segmentation was modified for application to a sparse and unequally–spaced dataset. The proposed algorithm evaluates the membership function of each sample using neighboring samples as a weighting function. To test the proposed algorithm, a synthetic dataset was analyzed by several hyper–parameter settings. Applying this algorithm to a geochemical dataset of granitoids in the Ina–Mikawa district of the Ryoke belt shows that samples collected from the same geological unit are likely to be classified as the same cluster. Moreover, overlapping geochemical trends are classified consistently with spatial distribution, and the result is more robust against noise addition than standard FCM analysis. The proposed method is a powerful tool to use with geological datasets with location coordinates, which are becoming increasingly available, and can help find overviews of complicated multidimensional data structure.

著者

Yu ITAMI Daisuke NAKAMURA Atsushi YASUMOTO Takao HIRAJIMA Martin SVOJTKA

出版者

Japan Association of Mineralogical Sciences

雑誌

Journal of Mineralogical and Petrological Sciences (ISSN:13456296)

巻号頁・発行日

vol.117, no.1, pp.220221, 2022 (Released:2022-10-28)

参考文献数

52

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The origins of eclogite associated with garnet peridotite in continent–continent collision belts are still debated. We performed petrological studies of eclogites collected from a garnet peridotite block from Nové Dvory in the Gföhl Unit of the Moldanubian Zone in the Variscan orogenic belt, Czech Republic. The eclogite was divided into three types: one kyanite (Ky)–bearing and two Ky–free types. Garnet and omphacite in the Ky–bearing eclogite have lower Fe contents than those in the Ky–free eclogite. Furthermore, the Ky–free eclogite was divided into two types on the basis of Ca content in garnet: Ca–rich (Xgrs > 0.32) and Ca–poor (Xgrs < 0.32) types, except for Ca–poor rim compositions. Application of conventional geothermobarometers to the Ky–bearing type and the Ky–free type with Ca–rich garnet yielded similar pressure–temperature (P–T) conditions (3.2–4.8 GPa and 920–1160 °C) to those of previous studies, whereas the Ky–free type with Ca–poor garnet yielded slightly lower P–T conditions (3.1–3.4 GPa and 950–990 °C) than the other two types. The observed chemical variation of garnet is probably due to the difference in origins, whereby, according to our new results and previous findings, the Ky–bearing eclogite was derived from plagioclase–bearing crustal gabbro, whereas the Ky–free eclogite with Ca–rich garnet was derived from a crystal cumulate possibly in the mantle wedge. In the Ky–free eclogite samples with Ca–poor garnet, chemical compositions of garnet and omphacite are different from those in the other Ky–free samples, and those samples with Ca–poor garnet would have a different origin from the others. One of the Ky–free type with Ca–poor garnet retains garnet grains with chemical zonings probably created during the prograde history, although the eclogite underwent the extremely high temperature (~ 1000 °C) metamorphism. Calculated diffusion distances in garnet reach 0.5 mm during 2 million years, even if we adopted a low value of diffusion coefficient data. Thus, the residence time of the eclogite at the peak meatamorphic conditions would have been shorter than at least 2 million years. The subsequent decompression and cooling after the peak metamorphism were also probably very fast to avoid the chemical homogenization of garnet.