- 著者
- Makoto Shibata Megumi Uchida Setsuki Tsukagoshi Koichi Yamaguchi Aya Yamaguchi Natsumi Furuta Kouki Makioka Toshitaka Maeno Yukio Fujita Masahiko Kurabayashi Yoshio Ikeda
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.54, no.23, pp.3057-3060, 2015 (Released:2015-12-01)
- 参考文献数
- 13
- 被引用文献数
- 5 9
A 64-year-old Japanese woman presented with a three-month history of progressive numbness and weakness of the lower extremities. A neurological examination and nerve conduction study indicated sensorimotor polyneuropathy. Since the serum anti-Hu antibody titer was remarkably elevated, paraneoplastic neurological syndrome was highly suspected. A thoracoscopic biopsy of the hilar lymph nodes, in which 18F-fluorodeoxyglucose uptake was obviously increased, revealed pathological findings for small-cell lung cancer (SCLC). Subsequently, the patient presented with generalized tonic-clonic seizures, and cerebral MRI showed reversible multifocal brain lesions, considered to reflect paraneoplastic encephalopathy. After two courses of chemotherapy for SCLC, the brain lesions totally disappeared.