著者
Makoto Shibata Megumi Uchida Setsuki Tsukagoshi Koichi Yamaguchi Aya Yamaguchi Natsumi Furuta Kouki Makioka Toshitaka Maeno Yukio Fujita Masahiko Kurabayashi Yoshio Ikeda
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.54, no.23, pp.3057-3060, 2015 (Released:2015-12-01)
参考文献数
13
被引用文献数
5 9

A 64-year-old Japanese woman presented with a three-month history of progressive numbness and weakness of the lower extremities. A neurological examination and nerve conduction study indicated sensorimotor polyneuropathy. Since the serum anti-Hu antibody titer was remarkably elevated, paraneoplastic neurological syndrome was highly suspected. A thoracoscopic biopsy of the hilar lymph nodes, in which 18F-fluorodeoxyglucose uptake was obviously increased, revealed pathological findings for small-cell lung cancer (SCLC). Subsequently, the patient presented with generalized tonic-clonic seizures, and cerebral MRI showed reversible multifocal brain lesions, considered to reflect paraneoplastic encephalopathy. After two courses of chemotherapy for SCLC, the brain lesions totally disappeared.
著者
Masahito Sato Satoru Fujita Atushi Saito Yoshio Ikeda Hitoshi Kitazawa Minoru Takahashi Junji Ishiguro Masaaki Okabe Yuichi Nakamura Tsuneo Nagai Hiroshi Watanabe Makoto Kodama Yoshifusa Aizawa
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.70, no.8, pp.947-953, 2006 (Released:2006-07-25)
参考文献数
24
被引用文献数
70 91

Background On October 23, 2004, a major earthquake, which registered 6.8 on the Richter scale, occurred in Niigata Prefecture in Japan. Emotional stress is important as a trigger of transient left ventricular apical ballooning (so-called `Takotsubo' cardiomyopathy), but its incidence and clinical profile immediately after a natural disaster have not been fully elucidated. Methods and Results `Takotsubo' cardiomyopathy was diagnosed in 16 patients (1 man, 15 women, mean age 71.5 years) within 1 month after the earthquake. Of them, 13 (81%) lived in areas where the Japan Meteorological Agency seismic intensity scale registered 6 or above, and 11 (69%) developed symptoms on the day of the earthquake. The incidence of `Takotsubo' cardiomyopathy 1 month after the earthquake was approximately 24-fold higher near the epicenter than that before the earthquake. Conclusion `Takotsubo' cardiomyopathy can occur on the day of the earthquake in elderly women living near the epicenter. (Circ J 2006; 70: 947 - 953)