- 著者
- Daisuke Shigemi Toshitaka Morishima Ayako Shibata Takahiro Tabuchi Hideo Yasunaga Isao Miyashiro
- 出版者
- Society for Clinical Epidemiology
- 雑誌
- Annals of Clinical Epidemiology (ISSN:24344338)
- 巻号頁・発行日
- vol.2, no.3, pp.75-83, 2020 (Released:2020-07-01)
- 参考文献数
- 28
- 被引用文献数
- 1
BACKGROUNDUnlike the recommendations made in many other countries, Japanese guidelines equally recommend radical hysterectomy or concurrent chemoradiotherapy for treatment of stage IIB cervical carcinoma. The main study objective was to compare the overall mortality of hysterectomy versus concurrent chemoradiotherapy as primary treatment in patients with localized or regionally extended cervical cancer.METHODSUsing Diagnosis Procedure Combination database combined with population-based cancer registry data in Osaka Prefecture, Japan, we conducted a retrospective cohort study. All adult patients who had been diagnosed with cervical cancer, registered in the population-based cancer registry from January 1, 2010 to December 31, 2015 were included. To compare overall mortality between patients who received radical hysterectomy and concurrent chemoradiotherapy as primary treatment, we performed a Cox regression analysis of the original cohort, and Kaplan-Meier analysis with stabilized inverse probability of treatment weights using propensity score.RESULTSAmong 740 eligible patients, 564 patients were included in the hysterectomy group and 176 patients were included in the concurrent chemoradiotherapy group. Primary hysterectomy was not independently associated with overall mortality (adjusted HR 0.70, 95% CI 0.46–1.07) by the Cox regression analysis. The Kaplan-Meier analysis with stabilized inverse probability of treatment weights did not show a significant difference in overall mortality between the two groups (P = 0.096).CONCLUSIONSThis study indicates that primary treatment type (hysterectomy versus concurrent chemoradiotherapy) was not statistically associated with overall mortality among patients diagnosed with localized or regionally extended cervical cancer.
- 著者
- Naoto Kuroda Ayako Shibata Takafumi Kubota
- 出版者
- JAPAN EPILEPSY SOCIETY
- 雑誌
- Epilepsy & Seizure (ISSN:18825567)
- 巻号頁・発行日
- vol.13, no.1, pp.31-35, 2021 (Released:2021-02-26)
- 参考文献数
- 17
The purpose of this review is to describe the impact of COVID-19 on women with epilepsy and how the issues are managed. From a review of relevant literature, we discuss special considerations for women with epilepsy during the COVID-19 crisis, which include menstruation, pregnancy, and living environment. We also propose comprehensive management including menstruation/pregnancy, medications, and mental stress. Through this review, the serious impact of COVID-19 on women with epilepsy is revealed. Epileptologists must understand these burdens in order to provide comprehensive support for women with epilepsy.