著者

Dawei Lin Chen Wu Yiwen Jiang Yigang Li Xi Zhang Yaosheng Wang

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

pp.2021.01461, (Released:2021-12-04)

参考文献数

20

被引用文献数

2

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It remains unknown whether and to what extend the angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) can play a role in the development of atrial fibrillation (AF) after pacemaker implantation in very old patients. Therefore, we aimed to investigate the association between oral ACEIs or ARBs and the risk of developing AF in very old patients after pacemaker implantation. Patients above 80 years old with pacemaker implantation and without baseline history of AF were included and their real-world information about ACEIs or ARBs use was extracted from electronic medical records. New AF cases were confirmed via the records of outpatient visits. The multivariable Cox proportional-hazards model was used to evaluate the associations between oral ACEIs or ARBs and risk of AF after pacemaker implantation. Among a total of 388 identified patients aged 80 to 98 years, 118 used ACEIs, 174 had ARBs therapy, and 115 AF were identified after pacemaker implantation during a median follow-up time of 3.1 years. After adjustment for potential confounders, patients with daily use of ARBs had a relatively lower risk of AF after pacemaker implantation (HR: 0.627, 95% CI: 0.425, 0.926; P = 0.019) compared with those non-users, whereas ACEIs therapy didn't show a significant relation with AF risk (HR: 1.335, 95% CI: 0.894, 1.995; P = 0.157). In conclusion, for very old patients with a permanent pacemaker, daily use of oral ARBs was associated with a relative lower risk of AF after pacemaker implantation, however, daily use of ACEIs was not related with AF risk.

著者

Chen Wu Dawei Lin Fei Ma Feng Jiang Yaosheng Wang

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

pp.2021.01278, (Released:2021-07-23)

参考文献数

51

被引用文献数

5

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Onco-cardiology is an emerging field linking cancer with cardiovascular injury. Understanding the mechanism of cardiac injury helps improve the quality of life of cancer survivors. A series of studies on adverse reactions to cancer or oncological treatments has indicated that adverse cardiovascular events related to cancer treatments may occur over a longer period of survival, and even years after therapy has concluded. Current cancer therapies, including chemotherapy, radiotherapy, targeted therapy, and immunotherapy, have been found to have latent cardiovascular toxicity. These toxic effects are often progressive and irreversible and ultimately lead to cardiovascular events such as heart failure, hypertension, coronary heart diseases, arrhythmia, and thromboembolism. Therefore, more emphasis should be placed on revealing the mechanism of cancer treatment-related cardiovascular toxicity. This would help to guide prevention, diagnosis, and treatment of CVDs in cancer survivors.

著者

Hung GUEI Ting-Han WEI I-Chen WU

出版者

The Japanese Society for Artificial Intelligence

雑誌

人工知能学会全国大会論文集

巻号頁・発行日

pp.2J1E501, 2019 (Released:2019-06-01)

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2048-like games are a family of single-player stochastic puzzle games, which consist of sliding numbered-tiles that combine to form tiles with larger numbers. Notable examples of games in this family include Threes!, 2048, and 2584. 2048-like games are highly suitable for educational purposes due to their simplicity and popularity. Numerous machine learning methods have been proposed for 2048, which provide a good opportunity for students to gain first-hand experience in applying these techniques. This paper summarizes the experience of using different 2048-like games, namely Threes! and 2584, as pedagogical tools for teaching reinforcement learning and computer game algorithms. With two classes of graduate level students, the average win rates for 2584 and Threes! reached 96.1% and 93.5%, respectively. The course designs were also well received by students, with 4.21/5 and 4.35/5 points from student feedbacks.