- 著者
- Chikako TANAKA Takayuki MIYAZAWA Masahisa WATARAI Naotaka ISHIGURO
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- vol.67, no.9, pp.951-953, 2005 (Released:2005-10-07)
- 参考文献数
- 17
- 被引用文献数
- 20 55
Some public areas in Japan such as parks and gardens can be highly contaminated with pigeon feces. We examined levels of four bacterial contaminations in fecal samples from feral pigeons in 7 prefectures. We isolated Salmonella Typhimurium and S. Cerro from 17 (3.9%) of 436 samples, as well as Mycobacterium spp. including M. avium-intracellulare complex from 29 (19.0%) of 153 samples. The polymerase chain reaction detected Chlamydia psittaci and C. pecorum in 106 (22.9%) of 463 samples, but E. coli O-157 was not isolated from any of the samples. Our results indicate that pigeon feces are a source of several zoonotic agents for birds, animals and humans.
1 0 0 0 OA Antimuscarinic Effects of Antihistamines: Quantitative Evaluation by Receptor-Binding Assay
- 著者
- Nobuo KUBO Osamu SHIRAKAWA Takayoshi KUNO Chikako TANAKA
- 出版者
- The Japanese Pharmacological Society
- 雑誌
- The Japanese Journal of Pharmacology (ISSN:00215198)
- 巻号頁・発行日
- vol.43, no.3, pp.277-282, 1987 (Released:2006-09-15)
- 参考文献数
- 17
- 被引用文献数
- 98 105
Quantitative evaluation of antimuscarinic effects of antihistamines (H1and H2-receptor antagonists) was carried out using a receptor-binding assay. The inhibition constants (K1 values) of twenty seven H1-receptor antagonists, one related antidepressant and three H2-receptor antagonists at H1-receptors and muscarinic receptors in the bovine cerebral cortex were determined. All the H2receptor antagonists examined showed very low affinity for the muscarinic receptors. On the other hand, some H1-receptor antagonists (mequitazine, cyproheptazine, clemastine, diphenylpyraline, promethazine, homochlorcyclizine and alimemazine) had high affinity for the muscarinic receptors (K1=5.0-38 nM). Another group of H1 -receptor antagonists (mepyramine, terfenadine, metapyrilen, azelastine, hydroxyzine and meclizine) had low affinity for the muscarinic receptors (K1=3, 600-30, 000 nM). Thus, a broad range of antimuscarinic potencies among the antihistamines was demonstrated. These results should provide helpful information with regard to the clinical and experimental use of antihistamines.