著者

Destici Eugin Oklejewicz Małgorzata Saito Shoko van der Horst Gijsbertus T.J.

出版者

Landes Bioscience

雑誌

Cell cycle (ISSN:15384101)

巻号頁・発行日

vol.10, no.21, pp.3788-3797, 2011-11

被引用文献数

21 8

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By gating cell cycle progression to specific times of the day, the intracellular circadian clock is thought to reduce the exposure of replicating cells to potentially hazardous environmental and endogenous genotoxic compounds. Although core clock gene defects that eradicate circadian rhythmicity can cause an altered in vivo genotoxic stress response and aberrant proliferation rate, it remains to be determined to what extent these cell cycle related phenotypes are due to a cell-autonomous lack of circadian oscillations. We investigated the DNA damage sensitivity and proliferative capacity of cultured primary Cry1‑/-