著者
Jun Matsuyama Kunihiro Tsuji Hisashi Doyama Fae Kim Yasuhito Takeda Yosuke Kito Renma Ito Hiroyoshi Nakanishi Tomoyuki Hayashi Yohei Waseda Shigetsugu Tsuji Kenichi Takemura Shinya Yamada Toshihide Okada Honin Kanaya
出版者
一般社団法人 日本内科学会
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.51, no.16, pp.2231-2234, 2012 (Released:2012-08-15)
参考文献数
18
被引用文献数
8 17

Severe hypomagnesemia is a serious clinical condition. Proton pump inhibitor (PPI) induced hypomagnesemia has been recognized since 2006. In March 2011 the U.S. Food and Drug Administration advised that long-term use of PPI can induce hypomagnesemia. We report the first Japanese case of hypomagnesemia associated with chronic use of PPIs in a 64-year-old man hospitalized for nausea, bilateral ankle arthritis, and tremor of the extremities who had convulsions 3 days after admission. Blood analysis showed severe hypomagnesemia. He had been taking rabeprazole (10 mg/day) for 5 years. After stopping rabeprazole and correcting the electrolytes imbalances, his symptoms improved without recurrence.