- 著者
-
TORU KINO
HIROSHI HATANAKA
SUSUMU MIYATA
NORIAKI INAMURA
MICHIHISA NISHIYAMA
TOSHIMI YAJIMA
TOSHIO GOTO
MASAKUNI OKUHARA
MASANOBU KOHSAKA
HATSUO AOKI
TAKENORI OCHIAI
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.40, no.9, pp.1256-1265, 1987-09-25 (Released:2006-04-19)
- 参考文献数
- 16
- 被引用文献数
-
241
780
The immuno-pharmacological profile of a novel immunosuppressive agent, FK-506 produced by a streptomycete, is presented here. We proceeded to test the effect of the agent on various in vitro immune systems. It showed that mixed lymphocyte reaction, cytotoxic T cell generation, the production of T cell-derived soluble mediators such as interleukin 2 (IL-2), interleukin 3 and gamma-interferon and the expression of the IL-2 receptor were suppressed by this agent. The IC50 values of FK-506 and ciclosporin (CS) in all tests were approximately 0.1nM and 10nM, respectively. Therefore, the novel agent, FK-506 suppressed in vitro immune systems at about hundred times lower concentration than CS.