著者

Mikio Sugano Homare Yoshida Hirotsugu Kurobe Hiroki Arase Hajime Kinoshita Takashi Kitaichi Noriko Sugasawa Soichiro Nakayama Kazuhisa Maeda Minoru Irahara Tetsuya Kitagawa

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.64, no.1.2, pp.43-49, 2017 (Released:2017-03-29)

参考文献数

27

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Objectives: To investigate the effects of human umbilical cord blood-derived mononuclear cell (hUCB-MNC) transplantation on pulmonary hypertension (PH) induced by monocrotaline (MCT) in immunodeficient mice and their distribution. Methods: MCT was administered to BALB/c Slc-nu/nu mice, and PH was induced in mice 4 weeks later. Fresh hUCB-MNCs harvested from a human donor after her delivery were injected intravenously into those PH mice. The medial thickness of pulmonary arterioles, ratio of right ventricular to septum plus left ventricular weight (RV/S+LV), and ratio of acceleration time to ejection time of pulmonary blood flow waveform (AT/ET) were determined 4 weeks after hUCB-MNC transplantation. To reveal the incorporation into the lung, CMTMR-labeled hUCB-MNCs were observed in the lung by fluorescent microscopy. DiR-labeled hUCB-MNCs were detected in the lung and other organs by bioluminescence images. Results: Medial thickness, RV/S+LV and AT/ET were significantly improved 4 weeks after hUCB-MNC transplantation compared with those in mice without hUCB-MNC transplantation. CMTMR-positive hUCB-MNCs were observed in the lung 3 hours after transplantation. Bioluminescence signals were detected more strongly in the lung than in other organs for 24 hours after transplantation. Conclusions: The results indicate that hUCB-MNCs are incorporated into the lung early after hUCB-MNC transplantation and improve MCT-induced PH. J. Med. Invest. 64: 43-49, February, 2017

著者

Hadiza Mohammed Inés Garcia-Lodeiro Hajime Kinoshita

出版者

Japan Concrete Institute

雑誌

Journal of Advanced Concrete Technology (ISSN:13473913)

巻号頁・発行日

vol.19, no.12, pp.1296-1308, 2021-12-23 (Released:2021-12-23)

参考文献数

28

被引用文献数

1

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Large quantities of aqueous secondary waste are generated from the processing of contaminated water after the nu-clear accident in Japan. Cementation of these wastes is challenging because their significant radioactivity may cause the radiolysis of water contents in cement, posing a risk of hydrogen gas generation. The application of calcium aluminate cement modified with phosphates (CAP), as an alternative cementing system, is interesting because this system is based on acid-base reaction, and its water content can be reduced by mild heating once the system is mixed. The present study focused in the use of Secar 71, a calcium aluminate cement with a high alumina and low silica compositions, and its effects of on the production of CAP system at elevated temperatures. The modification of Secar 71 with phosphates was successful, and the reduction of water content by about 35% was achieved in the CAP system containing SrCl2 after curing the system at 80°C for 7 days. The micro cracks, typically observed in the CAP system cured at lower temperature, was significantly reduced by curing at 80°C. The obtained results show a potential of Secar 71 to prepare CAP for cementation of aqueous secondary wastes.