著者

Naoto Suzue Tetsuya Matsuura Toshiyuki Iwame Kosaku Higashino Toshinori Sakai Daisuke Hamada Tomohiro Goto Yoichiro Takata Toshihiko Nishisho Yuichiro Goda Takahiko Tsutsui Ichiro Tonogai Ryo Miyagi Mitsunobu Abe Masatoshi Morimoto Kazuaki Mineta Tetsuya Kimura Akihiro Nitta Tadahiro Higuchi Shingo Hama Subash C. Jha Rui Takahashi Shoji Fukuta Koichi Sairyo

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.62, no.3.4, pp.109-113, 2015 (Released:2015-09-18)

参考文献数

39

被引用文献数

2 14

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Athletes sometimes experience overuse injuries. To diagnose these injuries, ultrasonography is often more useful than plain radiography, computed tomography (CT), or magnetic resonance imaging (MRI). Ultrasonography can show both bone and soft tissue from various angles as needed, providing great detail in many cases. In conditions such as osteochondrosis or enthesopathies such as Osgood-Schlatter disease, Sinding-Larsen-Johansson disease, bipartite patella, osteochondritis dissecans of the knee, painful accessory navicular,and jumper's knee, ultrasonography can reveal certain types of bony irregularities or neovascularization of the surrounding tissue. In patients of enthesopathy, ultrasonography can show the degenerative changes at the insertion of the tendon. Given its usefulness in treatment, ultrasonography is expected to become essential in the management of overuse injuries affecting the lower limb in athletes. J. Med. Invest. 62: 109-113, August, 2015

著者

Ryo Momosaki Shoji Kinoshita Wataru Kakuda Naoki Yamada Masahiro Abo

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.63, no.3.4, pp.153-158, 2016 (Released:2016-09-17)

参考文献数

26

被引用文献数

8

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The purpose of this study was to review the best available evidence of noninvasive brain stimulation, including repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) for dysphagia after acquired brain injury. We searched randomized controlled trials that compared noninvasive brain stimulation with control used to improve dysphagia after acquired brain injury. We assessed dysphagia severity rating scales and penetration-aspiration scale as outcomes immediately after intervention. We calculated the pooled estimate of the standardized mean difference (SMD) to combine individual results. We included 8 published studies. Two heterogenous trials of 48 patients showed that rTMS was associated with a significant improvement in the dysphagia severity rating scale score (SMD 2.95). Three homogeneous trials of 88 patients showed a significant effect of rTMS on the penetration-aspiration scale score (SMD 0.77). Two homogeneous trials of 34 patients showed that tDCS was associated with a significant improvement in the dysphagia severity rating scale score (SMD 1.20). The review provided low-quality evidence for the effectiveness of noninvasive brain stimulation in improving dysphagia after acquired brain injury. Further trials of larger sample sizes are needed to determine the most appropriate noninvasive brain stimulation protocol. J. Med. Invest. 63: 153-158, August, 2016

著者

Mikio Sugano Homare Yoshida Hirotsugu Kurobe Hiroki Arase Hajime Kinoshita Takashi Kitaichi Noriko Sugasawa Soichiro Nakayama Kazuhisa Maeda Minoru Irahara Tetsuya Kitagawa

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.64, no.1.2, pp.43-49, 2017 (Released:2017-03-29)

参考文献数

27

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Objectives: To investigate the effects of human umbilical cord blood-derived mononuclear cell (hUCB-MNC) transplantation on pulmonary hypertension (PH) induced by monocrotaline (MCT) in immunodeficient mice and their distribution. Methods: MCT was administered to BALB/c Slc-nu/nu mice, and PH was induced in mice 4 weeks later. Fresh hUCB-MNCs harvested from a human donor after her delivery were injected intravenously into those PH mice. The medial thickness of pulmonary arterioles, ratio of right ventricular to septum plus left ventricular weight (RV/S+LV), and ratio of acceleration time to ejection time of pulmonary blood flow waveform (AT/ET) were determined 4 weeks after hUCB-MNC transplantation. To reveal the incorporation into the lung, CMTMR-labeled hUCB-MNCs were observed in the lung by fluorescent microscopy. DiR-labeled hUCB-MNCs were detected in the lung and other organs by bioluminescence images. Results: Medial thickness, RV/S+LV and AT/ET were significantly improved 4 weeks after hUCB-MNC transplantation compared with those in mice without hUCB-MNC transplantation. CMTMR-positive hUCB-MNCs were observed in the lung 3 hours after transplantation. Bioluminescence signals were detected more strongly in the lung than in other organs for 24 hours after transplantation. Conclusions: The results indicate that hUCB-MNCs are incorporated into the lung early after hUCB-MNC transplantation and improve MCT-induced PH. J. Med. Invest. 64: 43-49, February, 2017

著者

Kiyotaka Hasebe Yu Okubo Koji Kaneoka Kohei Takada Daisuke Suzuki Koichi Sairyo

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.63, no.1.2, pp.85-90, 2016 (Released:2016-04-01)

参考文献数

26

被引用文献数

20

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Objectives: To ascertain the dynamic stretch effects of flexibility of the hamstrings on lumbar spine and pelvic kinematics. Background: Tight hamstrings are positively correlated with low back pain. However, it is unclear how flexibility of the hamstrings affects spino-pelvic rhythm. Methods: Twelve healthy men participated in the study. The straight leg raising (SLR) angle, finger floor distance (FFD), and spino-pelvic rhythm was measured before and after the 6-week stretching protocol. The forward bending task was divided into 4 phases. The paired t-test was used to determine significant differences before and after the FFD, SLR angle, lumbar motion, and pelvic motion, and spino-pelvic rhythm in each phase (p<0.05). Results: After 6 weeks of stretching, significant improvements were seen in the FFD with maximum forward bending and in the SLR angle. Total pelvic rotation was also significantly increased in contrast to total lumbar flexion. A decreased spino-pelvic ratio was seen in the final phase. Conclusion: Dynamic stretching could change the spino-pelvic rhythm to a pelvis-dominant motion, indicating that flexible hamstrings are important for preventing low back pain. J. Med. Invest. 63: 85-90, February, 2016

著者

Toshiyuki Iwame Tetsuya Matsuura Naoto Suzue Shinji Kashiwaguchi Takenobu Iwase Shoji Fukuta Daisuke Hamada Tomohiro Goto Takahiko Tsutsui Keizo Wada Hiroshi Egawa Akihiro Nagamachi Koichi Sairyo

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.63, no.3.4, pp.171-174, 2016 (Released:2016-09-17)

参考文献数

11

被引用文献数

10

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Purpose: Our aim was to examine the outcome of an elbow check-up system for youth baseball players. In particular, we investigated the nature of elbow injuries in youth baseball players with elbow pain and ultrasonographic findings of the capitellum. Materials and Methods: A total of 1605 players participating in the regional summer championship in July 2013 underwent a questionnaire survey, physical examination, ultrasound imaging, and radiographic examination. Results: A total of 499 (31.1%) players reported episodes of elbow pain, of whom 320 (64.1%) had abnormal findings on physical examination, and 115 (35.9%) agreed to undergo radiography. Among them, 98 (85.2%) exhibited radiographic abnormalities. On the initial ultrasonography screening, 60 (3.7%) players had an abnormal finding and 55 (91.7%) agreed to undergo radiography. Among them, 26 (47.3%) were found to have osteochondritis dissecans (OCD) of the capitellum on radiographs. Conclusions: About 30% of youth baseball players had episodes of elbow pain, and 64.1% of players with elbow pain had abnormal findings on physical examination. Furthermore, 85.2% of subjects who underwent radiographic examination exhibited radiographic abnormalities. About 4% of young baseball players had an abnormal finding on initial ultrasonography screening, and nearly 50% of them had OCD of the capitellum on radiographs. J. Med. Invest. 63: 171-174, August, 2016

著者

Yasuhiro Funakoshi Masafumi Harada Hideki Otsuka Kenji Mori Hiromichi Ito Takashi Iwanaga

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.63, no.3.4, pp.204-208, 2016 (Released:2016-09-17)

参考文献数

21

被引用文献数

19

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Purpose: The purpose of this study was to investigate changes in the functional connectivity of the default mode network (DMN) in normal aging and in children with autistic spectrum disorder (ASD) by using resting-state functional magnetic resonance imaging (rsfMRI) and independent component analysis. Methods: Thirty-one healthy controls (HC) in four age groups (1-3, 4-8, 20-29, and 50-59 years) and 14 childhood ASD cases (1-8 years of age) were examined by rsfMRI echo-planar imaging on a clinical 3-T MRI scanner. Imaging of all children (1-8 years) was conducted under sedation, while adults were scanned in the awake state with eyes closed. Results: The regions of DMN functional connectivity in the bilateral inferior parietal lobule and posterior cingulate cortex were smaller in HC children than in HC adults, and smaller in the ASD group than in the HC children. Conclusion: It is possible to observe developmental and pathological changes in the DMN by rsfMRI. Reduced DMN functional connectivity in children may be a useful biomarker for ASD diagnosis. J. Med. Invest. 63: 204-208, August, 2016

著者

Bei Zhou Hisami Yamanaka-Okumura Sayaka Seki Hiroshi Tatano Chisaki Adachi Eiji Takeda

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.61, no.1.2, pp.118-125, 2014 (Released:2014-04-04)

参考文献数

25

被引用文献数

1 4

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In general, vegetables are abundantly consumed in a calorie-restricted diet to achieve sufficient satiety through fresh food or various cooking methods. In this study, we examined the effects of different cooking methods on appetite and specific perceptions of the food after consumption; eating approaches were also analyzed by meal duration. A total of 153 individuals aged 20-59 years were assigned to 2 groups: raw vegetable or boiled vegetable meals, including packed meals that were served as test meals with the same energy and vegetable amount. Subjective levels of sensory properties and meal duration were assessed over time using visual analog scales, including questionnaires. Results showed that meal duration was significantly longer for raw vegetable meals than boiled vegetable meals, and there were significantly stronger correlations between meal duration and fullness. A higher degree of fullness was provided by a raw vegetable meal than a boiled vegetable meal, especially in men. However, an excess of raw vegetables led to overall insufficient satisfaction. Taken together, these findings suggest that cooking methods should be altered for different situations with an adequate amount of vegetables, and the meal duration should be recommended to be given as much attention as cooking methods. J. Med. Invest. 61: 118-125, February, 2014

著者

井上 菜津子 木村 佳乃実 中馬 歩美

出版者

徳島大学医学部

雑誌

JNI (ISSN:13483722)

巻号頁・発行日

vol.7, no.1, pp.43-51, 2009-03

著者

Yukihiko Ito Aya Mizukuchi Mitsuo Kise Hiromichi Aoto Shigeru Yamamoto Rie Yoshihara Jyunichi Yokoyama

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.52, no.3,4, pp.159-164, 2005 (Released:2005-09-20)

参考文献数

28

被引用文献数

31 72

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Effects of pre-germinated brown rice (PGBR) on postprandial blood glucose and insulin concentrations were compared with brown rice (BR) and white rice (WR) in two studies. In the first study, we investigated the time course of postprandial blood glucose and insulin concentrations after ingesting 25% (W/V) glucose solution, PGBR, BR or WR in 19 healthy young subjects. In the second study, dose-dependent effect of PGBR on the time course of postprandial blood glucose concentrations was compared among 4 different mixtures of PGBR and WR in 13 healthy young subjects. They were solely PGBR, 2/3 PGBR (PGBR: WR=2: 1), 1/3 PGBR (PGBR: WR=1: 2) and solely WR. Each sample was studied on a different day. The samples were selected randomly by the subjects. All the rice samples contained 50g of available carbohydrates. The previous day the subjects ate the assigned dinner by 9:00 pm and then were allowed only water until the examination. The next morning, they ingested each test rice sample with 150ml of water in 5-10 min. Blood was collected into capillary tubes from finger at 0, 30, 60, 90 and 120 min after the ingestion. The incremental areas under the curve (IAUC) of blood glucose concentrations (IAUC-Glc) for 120 min after the administration of PGBR and BR were lower than those after WR. In contrast the IAUC-Glc of BR and PGBR were not different (Study 1). The higher the ratio of PGBR/WR, the lower the glycemic index became (Study 2). These results suggest that intake of PGBR instead of WR is effective for the control of postprandial blood glucose concentration without increasing the insulin secretion. J. Med. Invest. 52: 159-164, August, 2005

著者

Hiroko Kunikata Kumi Watanabe Makoto Miyoshi Tetsuya Tanioka

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.59, no.1,2, pp.206-212, 2012 (Released:2012-03-08)

参考文献数

16

被引用文献数

7 28

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This study examined the effects of hand massage on autonomic activity, anxiety, relaxation and sense of affinity by performing it to healthy people before applying the technic in actual clinical practice. Findings were showed below: 1) the significant increase in the pNN50 and the significant decrease in the heart rate meant the intervention of massage increased the autonomic nervous activity, improved the parasympathetic nerve activity and reduced the sympathetic nerve activity. This means the subjects were considered to be in a state of relaxation. 2) Salivary α amylase has been reported as a possible indicator for sympathetic nerve activity. In this study, there was no significant difference in the salivary α amylase despite a decrease after massage. 3) State anxiety score is temporal situational reactions while being in the state of anxiety and this score decreased significantly after massage. 4) The level of willingness to communicate with other person and the sense of affinity toward the massage-performer had a positive change of 70 percent. From this, it can be considered that a comfortable physical contact between a patient and a nursing profession, who are in a supported-supportive relationship, leads to an effect of shortening the gap in their psychological distance. J. Med. Invest. 59: 206-212, February, 2012

著者

Hiroshi Tatano Hisami Yamanaka-Okumura Bei Zhou Chisaki Adachi Yuka Kawakami Takafumi Katayama Masashi Masuda Eiji Takeda Yutaka Taketani

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.63, no.3.4, pp.241-247, 2016 (Released:2016-09-17)

参考文献数

33

被引用文献数

6

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Reducing dietary calorie density (CD) is useful in body weight management. This study investigates the association between dietary habits and preferences for different CDs. We conducted a randomized crossover study of 232 healthy subjects who consumed packed lunch boxes containing a control, high-meat and low-rice, low-vegetable, medium-fat and low-vegetable, high-fat, and high-fat and low-vegetable meals over six sessions. The subjective levels of sensory properties were assessed over time using a visual analog scale and the area under the curve. Subjects were assessed for dietary habits using a brief-type self-administered diet history questionnaire (BDHQ) and were divided into two groups based on a daily fat energy ratio ≥ 25% (high fat [HF], n=116) and < 25% (normal, n=116) that was matched for age, body mass index, and sex ratio. Our findings indicate that the desire for sweetness was higher in the HF group than in the normal group, regardless of the meals consumed. Particularly, among the 500-kcal low-CD meals, a high-protein meal provided greater fullness and satisfaction and lower prospective consumption in the HF group than in the normal group. Therefore, our study demonstrates that postprandial appetite sensation is associated with dietary habits of fat intake. J. Med. Invest. 63: 241-247, August, 2016

著者

Eiji Takeda Junji Terao Yutaka Nakaya Ken-ichi Miyamoto Yoshinobu Baba Hiroshi Chuman Ryuji Kaji Tetsuro Ohmori Kazuhito Rokutan

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.51, no.3,4, pp.139-145, 2004 (Released:2004-10-27)

参考文献数

51

被引用文献数

30 69

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Stress is a pervasive factor in everyday life that critically affects development and functioning. Severe and prolonged stress exposure impairs homeostatic mechanisms, particularly associated with the onset of depressive illness. Brain food is aimed at preventing as well as treating a growing number of stress-related mental disorders. Some topics on the association of stress and nutrition is reviewed. (1) An increased activity of serotonergic neurons in the brain is an established consequence of stress. An increase in brain tryptophan levels on the order of that produced by eating a carbohydrate-rich/protein-poor meal causes parallel increases in the amounts of serotonin released into synapses. (2) Eating is thought to be suppressed during stress, due to anorectic effects of corticotrophin releasing hormone, and increased during recovery from stress, due to appetite stimulating effects of residual cortisol. (3) A strong inverse association between coffee intake and risk of suicide. (4) Night eating syndrome has been found to occur during periods of stress and is associated with poor results at attempts to lose weight and disturbances in the hypothalamic-pituitary-adrenal axis. (5) Dietary antioxidants present in fruits and vegetables may improve cognitive function. Therefore, it is concluded that the establishment of functional foods that correctly regulate stress response must be firmly based upon scientific knowledge and legal regulation.

著者

井上 菜津子 木村 佳乃実 中馬 歩美 多田 俊子

出版者

徳島大学医学部

雑誌

JNI (ISSN:13483722)

巻号頁・発行日

vol.7, no.1, pp.43-51, 2009-03

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【目的】車椅子利用者の安楽に及ぼす影響の1つとして「声かけ」に注目して,バリアが車椅子利用者の体感にどのような影響を及ぼすのかを知ることとを目的とした研究を行った.【方法】対象者は,20歳代女性の看護学生で,車椅子利用時の体感に体重が影響することを考慮し標準体重に近い者を選定した.路面の状態については,観察,自走介助兼用車椅子に装着した振動計,座席用振動ピックアップを用い客観的測定を行った.声かけによる路面の状態による主観的反応の相違は,対象者60人を無作為にA群の「声かけあり群(n=30)」と,B群の「声かけなし群(n=30)」の2群に分けて把握した.【倫理的配慮】対象者に本研究の目的及び方法を説明し,同意書に署名してもらった.【分析方法】アンケート調査結果について2群を比較した.ゆれ・恐怖感・乗り心地の段階評価においてはウィルコクソンの符号順位和検定を行った.【結果および考察】路面の見かけと振動値は概ね一致していたが,見かけは平らであっても振動値は高い場所もあった.路面に対する反応は以下の通りである.1.振動が大きいところでは対象者の全身に振動を与え,不快をもたらしていた.2.傾斜があるところでは対象者に恐怖感をもたらしていた.3.声かけは対象者が振動を予測して,態勢を整えることに役立っていた.4.声かけは安心感や気分転換等にもつながっていた.以上のことから,車椅子利用者の介助に当たって声かけをすることは重要であることが明らかになった.また,多様な路面の性状下でも快適な車椅子利用ができるような介助の方法を探究していきたい.さらに,今回の結果は,車椅子以外にもシルバーカーや自走車椅子利用者の支援のあり方を示唆するものと考えられる.

著者

有内 和代 楊河 宏章 宮本 登志子 井村 光子 西矢 昌子 中西 りか 苛原 稔

出版者

徳島大学医学部

雑誌

JNI (ISSN:13483722)

巻号頁・発行日

vol.3, no.2, pp.99-105, 2005-03

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治験は医薬品の開発において必須であり,その過程では逸脱を防ぎ,データの質を確保することが必要である.CRC(clinical research coordinator)の立場から,治験依頼者と医療機関の意思疎通のためのミーティングをより効率的に活用し,治験の品質の向上を行うためのチェックリストを作成した.T大学病院臨床試験管理センターのCRCがこれまでのミーティングにおいて経験した問題点を抽出し,それらを統合してミーティングチェックリストの原案を作成した.原案を平成16年5月~6月に治験が開始された6件において主担当CRCが使用し,必要時には修正,補充を行い,それらを追記内容として直接チェックリストに記載した.治験開始後にこれらのチェックリストを回収し,追記内容等について検討した.詳細な追記は,除外基準や費用の負担(特定療養費の期間に関する規定,入院時の取り扱いなど)などの項目で見られた.画像の取り扱い,同種同効薬と併用禁止薬,条件付き可能薬の一般名表記等においても指摘があった.追加項目として受託事例数が,修正項目として表記方法やレイアウトについての意見があった.これらを総合的に評価し,またあまりに詳細なリストは実用的ではないという意見なども取り入れ,除外基準は疾患名を列記しチェックする形に,また検査,投薬に関しては詳しい内容とするなどの変更を加え,最終的なチェックリストとした.治験における逸脱の原因として,治験依頼者,治験責任医師の間での記載内容の解釈の微妙な不一致の関与の可能性が指摘されている.その克服にはCRCが中心となった品質保証のシステム化が必要であり,今回作成したチェックリストの活用などが有用と考えられる.今後は逸脱防止を目的とし,チェックリストの改良や活用法の検討を重ね対応するとともに,チェックリスト使用の有用性に関する評価を行う予定である.

著者

Tosiaki Aoyama Naohisa Nosaka Michio Kasai

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.54, no.3,4, pp.385-388, 2007 (Released:2007-09-11)

参考文献数

11

被引用文献数

33 68

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Medium-chain fatty acids (MCFA) have attracted attention as part of a healthy diet, because they are absorbed and transported directly into the liver via the portal vein, metabolized rapidly by β-oxidation, and increase diet-induced thermogenesis. Because medium-chain triacylglycerols (MCT) containing only MCFA has a few weak points as frying oils, we have developed medium- and long-chain triacylglycerols (MLCT). MLCT is produced by lipase-catalyzed enzymatic transesterification. Recently, long-term clinical trials have demonstrated that MLCT and MCT result in less body fat-deposition. MLCT oil (Trade name: Healthy Resseta) is safe and can be substitute for common edible vegetable oils. Healthy Resseta has been approved as FOSHU (Food for Specified Health Use), by the Ministry of Health, Labour and Welfare of Japan in December 2002 for use as a cooking oil with a suppressing effect on body fat accumulation. Healthy Resseta is widely sold in Japan. J. Med. Invest. 54: 385-388, August, 2007

著者

Yosuke Kakisaka Kazutaka Jin Mayu Fujikawa Yu Kitazawa Kazuhiro Kato Nobukazu Nakasato

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.64, no.3.4, pp.296-298, 2017 (Released:2017-09-27)

参考文献数

13

被引用文献数

3

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Multiple chemical sensitivity (MCS) is a disorder of unknown etiology with no effective treatment. Many clinicians accept that a diagnosis of somatic symptoms disorder (SSD) is an appropriate diagnostic category for MCS. We found that administration of levetiracetam improved recurrent symptoms of MCS in a patient. A 23-year-old female presented with recurrent multiple symptoms of musculoskeletal, airway or mucous membrane, heart/chest-related, gastrointestinal, cognitive, affective, neuromuscular, head-related, and skin-related induced by exposure to diesel or gas engine exhaust, tobacco smoke, insecticide, gasoline, paint or paint thinner, cleaning products, fragrances, tar or asphalt, nail polish or hairspray, and new furnishings. Gastrointestinal, cognitive, and skin-related symptoms were precipitated by some food additives. She suffered partial seizures from the age of 17 years, and was diagnosed with right parietal lobe epilepsy. Administration of levetiracetam (250 mg/day) eliminated her MCS symptoms. Levetiracetam reduces the release of presynaptic neurotransmitter including glutamate by binding to presynaptic vesicle protein. A recent study established the presence of glutamatergic overactivation in somatization disorder, a form of SSD. Our case may indicate that a subset of patients with SSD have glutamatergic overactivation, which levetiracetam can normalize. J. Med. Invest. 64: 296-298, August, 2017

著者

Saiko Shikanai Ly Koung Ry Hitomi Takeichi Suzuki Emiko Pann San Nobuko Sarukura Sumiko Kamoshita Shigeru Yamamoto

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.61, no.1.2, pp.72-78, 2014 (Released:2014-04-04)

参考文献数

21

被引用文献数

4 11

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Because of the tastiness of sugars, it is easy to consume more than an adequate amount. There are many research reports that excess sugar intake contributes to dental decay, obesity, diabetes etc. Continuing economic development in Cambodia has made it easier than before for people to consume sugars in their daily life. Currently, isomerized sugar (a mixture of glucose and fructose) made from starches is commonly used in commercial beverages because of its low price. However, in Cambodia and Japan, sugar composition tables that include not only sucrose but also glucose, fructose, lactose and maltose have not been available. Prior to the present nutrition surveys, we made sugar composition tables for both countries. In this study we tried to estimate the intakes of various sugars by children in Cambodia and Japan and to determine the relationship between intake and body weight. Nutrition surveys of children aged 7, 10 and 13 years old were conducted for 3 nonconsecutive days by the 24 h recall method in 89 Cambodian children living in the capital city of Cambodia, Phnom Penh, and 151 Japanese children living in 3 prefectures from north to south. Height and weight of children in Cambodia and Japan were similar until 10 years old but at 13 years old, the Cambodians were shorter and lighter than the Japanese. We could not observe any differences in BMI in either country. The sugar intakes from beverages and snacks were not different among the different gender and age. Thus we combined the mean total sugar intake for Cambodian and Japanese, 28.42 ± 25.28 g and 25.69 ± 16.16 g respectively. These were within the range of WHO recommendations (less than 10% of energy intakes). Cambodian children consumed about 46% of sugars from commercial beverages and snacks and Japanese children 26%. This means that for Cambodians half of the sugars came from isomerized sugar made from starches. Relationships between sugar intake and body weight were not observed in both countries. In conclusion, the Cambodian children consumed about 46% of sugar from glucose and fructose (probably in the form of isomerized sugar), while the Japanese children took 26%; however, the intakes in both countries met the WHO recommendation and there was no relationship to body weight. J. Med. Invest. 61: 72-78, February, 2014

著者

Koichi Sairyo Kosaku Higashino Kazuta Yamashita Fumio Hayashi Keizo Wada Toshinori Sakai Yoichiro Takata Fumitake Tezuka Masatoshi Morimoto Tomoya Terai Takashi Chikawa Hiroshi Yonezu Akihiro Nagamachi Yoshihiro Fukui

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.64, no.1.2, pp.1-6, 2017 (Released:2017-03-29)

参考文献数

32

被引用文献数

30

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Percutaneous endoscopic surgery for the lumbar spine, which was established in the last decade, requires only an 8-mm skin incision and causes minimal damage to the paravertebral muscles; thus, it is considered to be a minimally invasive technique for spinal surgery. It has been used to perform percutaneous endoscopic discectomy via two main approaches: the TF approach is a posterolateral one through the intervertebral foramen and can be done under local anesthesia; the IL approach is a more traditional one through the interlaminar space and is difficult to perform under local anesthesia. Recently, these techniques have been applied for lumbar spinal stenosis (LSS), the TF method for foraminal stenosis under local anesthesia, and the IL method for central and lateral recess stenosis under general anesthesia. In this study, using a fresh human cadaver model, we performed simultaneous decompression of the lateral recess and foraminal stenosis at L4-5 using the TF approach. Computed tomography confirmed enlargement of the lateral recess and intervertebral foramen. This technique, which can be performed under local anesthesia, should benefit elderly patients with LSS and poor general condition due to multiple comorbidities. Finally, we introduce the concept of percutaneous transforaminal ventral facetectomy using a spinal percutaneous endoscope. J. Med. Invest. 64: 1-6, February, 2017

著者

Yoko Tanemura Hisami Yamanaka-Okumura Masae Sakuma Yoshitaka Nii Yutaka Taketani Eiji Takeda

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.61, no.3.4, pp.291-297, 2014 (Released:2014-09-27)

参考文献数

28

被引用文献数

2 23

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Long-term suppression of postprandial glucose concentration is an important dietary strategy for the prevention and treatment of type 2 diabetes. Because previous reports have suggested that seaweed may exert anti-diabetic effects in animals, the effects of Wakame or Mekabu intake with 200 g white rice, 50 g boiled soybeans, 60 g potatoes, and 40 g broccoli on postprandial glucose, insulin and free fatty acid levels were investigated in healthy subjects. Plasma glucose levels at 30 min and glucose area under the curve (AUC) at 0-30 min after the Mekabu meal were significantly lower than that after the control meal. Plasma glucose and glucose AUC were not different between the Wakame and control meals. Postprandial serum insulin and its AUC and free fatty acid concentration were not different among the three meals. In addition, fullness, satisfaction, and wellness scores were not different among the three meals. Thus, consumption of 70 g Mekabu with a white rice-based breakfast reduces postprandial glucose concentration. J. Med. Invest. 61: 291-297, August, 2014

著者

Eiji Takeda Junji Terao Yutaka Nakaya Ken-ichi Miyamoto Yoshinobu Baba Hiroshi Chuman Ryuji Kaji Tetsuro Ohmori Kazuhito Rokutan

出版者

徳島大学医学部

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.51, no.3,4, pp.139-145, 2004 (Released:2004-10-27)

参考文献数

51

被引用文献数

30 69

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Stress is a pervasive factor in everyday life that critically affects development and functioning. Severe and prolonged stress exposure impairs homeostatic mechanisms, particularly associated with the onset of depressive illness. Brain food is aimed at preventing as well as treating a growing number of stress-related mental disorders. Some topics on the association of stress and nutrition is reviewed. (1) An increased activity of serotonergic neurons in the brain is an established consequence of stress. An increase in brain tryptophan levels on the order of that produced by eating a carbohydrate-rich/protein-poor meal causes parallel increases in the amounts of serotonin released into synapses. (2) Eating is thought to be suppressed during stress, due to anorectic effects of corticotrophin releasing hormone, and increased during recovery from stress, due to appetite stimulating effects of residual cortisol. (3) A strong inverse association between coffee intake and risk of suicide. (4) Night eating syndrome has been found to occur during periods of stress and is associated with poor results at attempts to lose weight and disturbances in the hypothalamic-pituitary-adrenal axis. (5) Dietary antioxidants present in fruits and vegetables may improve cognitive function. Therefore, it is concluded that the establishment of functional foods that correctly regulate stress response must be firmly based upon scientific knowledge and legal regulation.