著者

竹本 洋 Hiroshi Takemoto

雑誌

時計台 (ISSN:09183639)

巻号頁・発行日

no.78, pp.12-15, 2008-04-01

著者

Shun Utsunomiya Yusuke Kishi Masafumi Tsuboi Daichi Kawaguchi Yukiko Gotoh Manabu Abe Kenji Sakimura Kazuma Maeda Hiroshi Takemoto

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

Drug Discoveries & Therapeutics (ISSN:18817831)

巻号頁・発行日

pp.2021.01017, (Released:2021-03-08)

参考文献数

48

被引用文献数

3

---

Immature neurons undergo morphological and physiological maturation in order to establish neuronal networks. During neuronal maturation, a large number of genes change their transcriptional levels, and these changes may be mediated by chromatin modifiers. In this study, we found that the level of Ezh1, a component of Polycomb repressive complex 2 (PRC2), increases during neuronal maturation in mouse neocortical culture. In addition, conditional knockout of Ezh1 in post-mitotic excitatory neurons leads to downregulation of a set of genes related to neuronal maturation. Moreover, the locus encoding Cpg15/Neuritin (Nrn1), which is regulated by neuronal activity and implicated in stabilization and maturation of excitatory synapses, is a direct target of Ezh1 in cortical neurons. Together, these results suggest that elevated expression of Ezh1 contributes to maturation of cortical neurons.

著者

竹本 洋 Hiroshi Takemoto

雑誌

経済学論究 (ISSN:02868032)

巻号頁・発行日

vol.70, no.3, pp.1-40, 2016-12-20

著者

竹本 洋 Hiroshi Takemoto

雑誌

経済学論究 (ISSN:02868032)

巻号頁・発行日

vol.63, no.3, pp.709-733, 2009-12-15