- 著者
- Masahiro TAGAWA Yasushi HARA Hiroyasu EJIMA Shinobu KOMORI Toru R. SAITO Kazuaki W. TAKAHASHI Kyoji HIOKI Susumu EBUKURO
- 出版者
- Japanese Association for Laboratory Animal Science
- 雑誌
- Experimental Animals (ISSN:13411357)
- 巻号頁・発行日
- vol.44, no.1, pp.49-55, 1995 (Released:2003-12-23)
- 参考文献数
- 19
This study was undertaken to evaluate the sedative effect of medetomidine, an α2-adrenoceptor agonist, and the counteractive effect of atipamezole, an antagonist to medetomidine, in house musk shrews (Suncus murinus). Two hundred, 300, 400, or 600 μg/kg of medetomidine was intraperitoneal injected into 89 house musk shrews. A sedative effect was produced in one to two minutes after injection. The dose-dependent prolongation of the sedative duration and the dose-dependent appearance of a hypothermic effect were demonstrated. With 200 μg/kg of medetomidine, the sedative effect obtained was not adequate in some of the animals. With 300 μg/kg and above, a stable sedative state was induced in all the animals. The duration of sedation in the house musk shrews was much longer (p<0.01) in males than in females. This suggested the higher susceptibility of male house musk shrews to this drug. The sedative effect and hypothermia obtained with 400 μg/kg of medetomidine were completely counteracted by more than 2.0 mg/kg of atipamezole. With 0.5 and 1.0 mg/kg of atipamezole, only a partial antagonistic action was produced. Transient vomiting appeared in 4.5% of the house musk shrews at approximately one minute after injection of medetomidine. This side-effect had occurred before the sedative effect was obtained, and was not serious enough to be a problem. None of the 89 house musk shrews died in this experiment. The above results show that the combination of medetomidine and atipamezole is a highly effective and safe anesthetic treatment which permits easy handling of house musk shrews.
- 著者
- Mineo HAYASAKI Mikako UENO Hiroyasu EJIMA Akira MUNAKATA Yukio TAMURA
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.12-0206, (Released:2012-10-15)
- 被引用文献数
- 1 2
A dog was suspected of suffering from ectopic Dirofilaria immitis infection, because a large white nematode worm was detected in the anterior chamber of the left eye. A cylinder-shaped fibrin sac in the anterior chamber was found in the eye of the dog by slit lamp microscopy. After successful surgical removal of the worm, the corneal wound produced by the keratotomy healed in a short period. The worm was estimated to be extremely young, 5th-stage-immature male D. immitis, equivalent to a 90–120-day-old worm postinfection, by close morphological measurement and an experimental infection study. Thus, an immature worm can exhibit erratic parasitism in a host’s eye. The fibrin sac was considered to be a trace of the invasion route, and the cornea may have been the port of entry into the anterior chamber of the eye in the erratic migration of D. immitis.