- 著者
- Ju Myeong Jin Hong Young-Joo Makita Shuichi Lim Yiheng Kurokawa Kazuhiro Duan Lian Miura Masahiro Tang Shuo Yasuno Yoshiaki
- 出版者
- Optical Society of America
- 雑誌
- Optics Express (ISSN:10944087)
- 巻号頁・発行日
- vol.21, no.16, pp.19412-19436, 2013-08
- 被引用文献数
- 95
An advanced version of Jones matrix optical coherence tomography (JMT) is demonstrated for Doppler and polarization sensitive imaging of the posterior eye. JMT is capable of providing localized flow tomography by Doppler detection and investigating the birefringence property of tissue through a three-dimensional (3-D) Jones matrix measurement. Owing to an incident polarization multiplexing scheme based on passive optical components, this system is stable, safe in a clinical environment, and cost effective. Since the properties of this version of JMT provide intrinsic compensation for system imperfection, the system is easy to calibrate. Compared with the previous version of JMT, this advanced JMT achieves a sufficiently long depth measurement range for clinical cases of posterior eye disease. Furthermore, a fine spectral shift compensation method based on the cross-correlation of calibration signals was devised for stabilizing the phase of OCT, which enables a high sensitivity Doppler OCT measurement. In addition, a new theory of JMT which integrates the Jones matrix measurement, Doppler measurement, and scattering measurement is presented. This theory enables a sensitivity-enhanced scattering OCT and high-sensitivity Doppler OCT. These new features enable the application of this system to clinical cases. A healthy subject and a geographic atrophy patient were measured in vivo, and simultaneous imaging of choroidal vasculature and birefringence structures are demonstrated.
- 著者
- Duan Lian Hong Young-Joo Yasuno Yoshiaki
- 出版者
- Optical Society of America
- 雑誌
- Optics Express (ISSN:10944087)
- 巻号頁・発行日
- vol.21, no.13, pp.15787-15808, 2013-06
- 被引用文献数
- 25
An automated choroidal vessel segmentation and quantification method for high-penetration optical coherence tomography (OCT) was developed for advanced visualization and evaluation of the choroidal vasculature. This method uses scattering OCT volumes for the segmentation of choroidal vessels by using a multi-scale adaptive threshold. The segmented choroidal vessels are then processed by multi-scale morphological analysis to quantify the vessel diameters. The three-dimensional structure and the diameter distribution of the choroidal vasculature were then obtained. The usefulness of the method was then evaluated by analyzing the OCT volumes of normal subjects.
- 著者
- Hong Young-Joo Makita Shuichi Jaillon Franck Ju Myeong Jin Min Eun Jung Lee Byeong Ha Itoh Masahide Miura Masahiro Yasuno Yoshiaki
- 出版者
- Optical Society of America
- 雑誌
- Optics Express (ISSN:10944087)
- 巻号頁・発行日
- vol.20, no.3, pp.2740-2760, 2012-01
- 被引用文献数
- 50
A high-penetration swept-source optical coherence tomography (HP-SS-OCT) system based on a 1-μm short cavity laser is developed. Doppler OCT processing is applied, along with a custom-made numerical phase stabilization algorithm; this process does not require additional calibration hardware. Thus, our phase stabilization method is simple and can be employed in a variety of SS-OCT systems. The bidirectional blood flow and vasculature in the deep choroid was successfully imaged via two Doppler modes that use different time intervals for Doppler processing. En face projection image of squared power of Doppler shift is compared to ICGA, and the utility of our method is verified.