- 著者
- Ju Myeong Jin Hong Young-Joo Makita Shuichi Lim Yiheng Kurokawa Kazuhiro Duan Lian Miura Masahiro Tang Shuo Yasuno Yoshiaki
- 出版者
- Optical Society of America
- 雑誌
- Optics Express (ISSN:10944087)
- 巻号頁・発行日
- vol.21, no.16, pp.19412-19436, 2013-08
- 被引用文献数
- 95
An advanced version of Jones matrix optical coherence tomography (JMT) is demonstrated for Doppler and polarization sensitive imaging of the posterior eye. JMT is capable of providing localized flow tomography by Doppler detection and investigating the birefringence property of tissue through a three-dimensional (3-D) Jones matrix measurement. Owing to an incident polarization multiplexing scheme based on passive optical components, this system is stable, safe in a clinical environment, and cost effective. Since the properties of this version of JMT provide intrinsic compensation for system imperfection, the system is easy to calibrate. Compared with the previous version of JMT, this advanced JMT achieves a sufficiently long depth measurement range for clinical cases of posterior eye disease. Furthermore, a fine spectral shift compensation method based on the cross-correlation of calibration signals was devised for stabilizing the phase of OCT, which enables a high sensitivity Doppler OCT measurement. In addition, a new theory of JMT which integrates the Jones matrix measurement, Doppler measurement, and scattering measurement is presented. This theory enables a sensitivity-enhanced scattering OCT and high-sensitivity Doppler OCT. These new features enable the application of this system to clinical cases. A healthy subject and a geographic atrophy patient were measured in vivo, and simultaneous imaging of choroidal vasculature and birefringence structures are demonstrated.
- 著者
- Duan Lian Hong Young-Joo Yasuno Yoshiaki
- 出版者
- Optical Society of America
- 雑誌
- Optics Express (ISSN:10944087)
- 巻号頁・発行日
- vol.21, no.13, pp.15787-15808, 2013-06
- 被引用文献数
- 25
An automated choroidal vessel segmentation and quantification method for high-penetration optical coherence tomography (OCT) was developed for advanced visualization and evaluation of the choroidal vasculature. This method uses scattering OCT volumes for the segmentation of choroidal vessels by using a multi-scale adaptive threshold. The segmented choroidal vessels are then processed by multi-scale morphological analysis to quantify the vessel diameters. The three-dimensional structure and the diameter distribution of the choroidal vasculature were then obtained. The usefulness of the method was then evaluated by analyzing the OCT volumes of normal subjects.
- 著者
- Yamanari Masahiro Ishii Kotaro Fukuda Shinichi Lim Yiheng Duan Lian Makita Shuichi Miura Masahiro Oshika Tetsuro Yasuno Yoshiaki
- 出版者
- Public Library of Science
- 雑誌
- PLoS ONE (ISSN:19326203)
- 巻号頁・発行日
- vol.7, no.9, pp.e44026, 2012-09
- 被引用文献数
- 26 5
PurposeTo investigate a relationship between birefringence and elasticity of porcine sclera ex vivo using polarization-sensitive optical coherence tomography (PS-OCT).MethodsElastic parameters and birefringence of 19 porcine eyes were measured. Four pieces of scleral strips which were parallel to the limbus, with a width of 4 mm, were dissected from the optic nerve head to the temporal side of each porcine eye. Birefringence of the sclera was measured with a prototype PS-OCT. The strain and force were measured with a uniaxial material tester as the sample was stretched with a speed of 1.8 mm/min after preconditioning. A derivative of the exponentially-fitted stress-strain curve at 0% strain was extracted as the tangent modulus. Power of exponential stress-strain function was also extracted from the fitting. To consider a net stiffness of sclera, structural stiffness was calculated as a product of tangent modulus and thickness. Correlations between birefringence and these elastic parameters were examined.ResultsStatistically significant correlations between birefringence and all of the elastic parameters were found at 2 central positions. Structural stiffness and power of exponential stress-strain function were correlated with birefringence at the position near the optic nerve head. No correlation was found at the position near the equator.ConclusionsThe evidence of correlations between birefringence and elasticity of sclera tested uniaxially was shown for the first time. This work may become a basis for in vivo measurement of scleral biomechanics using PS-OCT.