著者

Noboru KOBAYASHI Ichiro YAMAMOTO

出版者

Atomic Energy Society of Japan

雑誌

Journal of Nuclear Science and Technology (ISSN:00223131)

巻号頁・発行日

vol.34, no.3, pp.318-324, 1997-03-25 (Released:2008-04-18)

参考文献数

6

被引用文献数

1

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By making use of the isotope approximation; neglecting squares of relative mass differences among the isotopes, the authors derived analytically approximations to ordinary diffusion coefficients in a 3- and 4- component isotope mixture. Moreover, approximations to multi-component diffusion coefficients were given on the analogy of those to the 3- and 4-component coefficients, and these approximations were verified to satisfy constrains on the exact ordinary diffusion coefficients. For 4-component mixture of uranium hexafluoride isotopes, 234UF6-235UF6-236UF6-236UF6, composition dependences of the approximation were equal to those of the exact diffusion coefficients. In addition, relative errors between the exact and the approximations were less than 0.2% for 5-component mixture of krypton 80-82-83-84-86 isotopes.

著者

Shingo ISHIKAWA Hiroshi TAKEMITSU Makoto HABARA Nobuko MORI Ichiro YAMAMOTO Toshiro ARAI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.77, no.12, pp.1681-1684, 2015 (Released:2016-01-01)

参考文献数

28

被引用文献数

4

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Nuclear factor κB (NF-κB) is a key factor in the development of chronic inflammation and is deeply involved in age-related and metabolic diseases development. These diseases have become a serious problem in cats. Sirtuin 1 (SIRT1) is associated with aging and metabolism through maintaining inflammation via NF-κB. In addition, fibroblasts are considered an important factor in the development of chronic inflammation. Therefore, we aimed to examine the effect of cat SIRT1 (cSIRT1) on NF-κB in cat fibroblast cells. The up-regulation of NF-κB transcriptional activity and pro-inflammatory cytokine mRNA expression by p65 subunit of NF-κB and lipopolysaccharide was suppressed by cSIRT1 in cat fibroblast cells. Our findings show that cSIRT1 is involved in the suppression of inflammation in cat fibroblast cells.

著者

Shingo ISHIKAWA Hiroshi TAKEMITSU Makoto HABARA Nobuko MORI Ichiro YAMAMOTO Toshiro ARAI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0245, (Released:2015-07-13)

被引用文献数

4

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Nuclear factor κB (NF-κB) is a key factor in the development of chronic inflammation and is deeply involved in age-related and metabolic diseases development. These diseases have become a serious problem in cats. Sirtuin 1 (SIRT1) is associated with aging and metabolism through maintaining inflammation via NF-κB. In addition, fibroblasts are considered an important factor in the development of chronic inflammation. Therefore, we aimed to examine the effect of cat SIRT1 (cSIRT1) on NF-κB in cat fibroblast cells. The up-regulation of NF-κB transcriptional activity and pro-inflammatory cytokine mRNA expression by p65 subunit of NF-κB and lipopolysaccharide was suppressed by cSIRT1 in cat fibroblast cells. Our findings show that cSIRT1 is involved in the suppression of inflammation in cat fibroblast cells.

著者

Masahiro MIYABE Azusa GIN Eri ONOZAWA Mana DAIMON Hana YAMADA Hitomi ODA Akihiro MORI Yutaka MOMOTA Daigo AZAKAMI Ichiro YAMAMOTO Mariko MOCHIZUKI Toshinori SAKO Katsutoshi TAMURA Katsumi ISHIOKA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0031, (Released:2015-05-10)

被引用文献数

2 11

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G protein-coupled receptor (GPR) 120 is an unsaturated fatty acid receptor, which is associated with various physiological functions. It is reported that the genetic variant of GPR120, p.Arg270His, is detected more in obese people, and this genetic variation functionally relates to obesity in humans. Obesity is a common nutritional disorder also in dogs, but the genetic factors have not ever been identified in dogs. In this study, we investigated the molecular structure of canine GPR120 and searched for candidate genetic variants which may relate to obesity in dogs. Canine GPR120 was highly homologous to those of other species, and seven transmembrane domains and two N-glycosylation sites were conserved. GPR120 mRNA was expressed in lung, jejunum, ileum, colon, hypothalamus, hippocampus, spinal cord, bone marrow, dermis and white adipose tissues in dogs, as those in mice and humans. Genetic variants of GPR120 were explored in client-owned 141 dogs, resulting in that 5 synonymous and 4 non-synonymous variants were found. The variant c.595C>A (p.Pro199Thr) was found in 40 dogs, and the gene frequency was significantly higher in dogs with higher body condition scores, i.e. 0.320 in BCS4-5 dogs, 0.175 in BCS3 dogs and 0.000 in BCS2 dogs. We conclude that c.595C>A (p.Pro199Thr) is a candidate variant relating to obesity, which may be helpful for nutritional management of dogs.