- 著者
- Li Shen Xiaoxia Liu Geng Feng Fu Shixuan Hao Minghui Zhang Ting Wang Jing Yang Xiao Wu Lingxiang Mao
- 出版者
- 国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
- 雑誌
- Japanese Journal of Infectious Diseases (ISSN:13446304)
- 巻号頁・発行日
- pp.JJID.2015.464, (Released:2016-06-30)
- 参考文献数
- 27
- 被引用文献数
- 1 9
To investigate the epidemic of HIV, HCV and syphilis, HIV-1 subtype among men who have sex with men (MSM) and to measure factors that correlated with sexual transmitted infections (STIs), a cross-sectional survey was conducted among 657 MSM in Zhenjiang, Jiangsu, during 2012-2013. Social-demographic characterization and risky behaviors were collected and blood samples were obtained. In this survey, the prevalence of STIs of HIV (5.3%), HCV (0.6%) and syphilis (19.2%) were measured. Of 35 HIV-infected MSM, 1 (0.2%) and 17 (2.6%) were co-infected with HCV and syphilis. Among 33 samples with available HIV-1 genomic fragments sequences, 6.1% B, 72.7% CRF01_AE and 21.2% CRF07_BC were indentified. Multivariate logistic regression analysis showed that age>30 years (OR 2.002; 95% CI 1.144 to 3.502) and having had STIs symptoms in the past year (OR 11.673; 95% CI 3.092 to 44.078) were positively correlated with STIs positive, while consistently use condom when have sex with male partners (OR 0.621; 95% CI 0.408 to 0.945) was significantly associated with a low STIs rate. The worsening epidemic of HIV, HCV and syphilis, complex subtypes of HIV-1 and risk factors suggest that effective intervention strategies should be strengthened for MSM in Zhenjiang, Jiangsu.
- 著者
- Jie WANG Xinliang LI Yongyi GAN Tianxing FAN Jing YANG Fang RAO Jianbo YANG
- 出版者
- Center for Academic Publications Japan
- 雑誌
- Journal of Nutritional Science and Vitaminology (ISSN:03014800)
- 巻号頁・発行日
- vol.68, no.3, pp.181-188, 2022-06-30 (Released:2022-06-30)
- 参考文献数
- 57
- 被引用文献数
- 1
We aimed to assess the difference and agreement between the CL-series Vitamin D Total assay (Mindray), which was a kind of chemiluminescent immunoassay (CLIA) and liquid chromatography–tandem mass spectrometry (LC-MS/MS) in the measurement of serum 25-hydroxyvitamin D [25(OH)D] concentrations in children. We compared the 25(OH)D concentrations of 92 children using the CLIA and LC-MS/MS. Paired samples t-test was used to compare the two groups. Linear regression was used to show the correlation between CLIA and LC-MS/MS. The difference and bias between 2 methods were revealed in Bland-Altman plot. Agreement in classification of deficiency between CLIA and LC-MS/MS was assessed using Cohen’s Kappa. p value<0.05 was considered statistically significant. Using Shapiro-Wilk Test to assess whether the data follows a normal distribution. Using 95% children’s serum 25(OH)D concentrations by LC-MS/MS as the reference interval. The regression equation was CLIA=1.185×LC-MS/MS−3.328. The fitness adjusted r2 was 0.589. The CLIA showed positive bias compared to LC-MS/MS, p<0.05, bias=(1.94±16.56) ng/mL. Cohen’s Kappa=0.53, p<0.001. The agreement of 2 methods in diagnosing “deficiency” was good. According to Shapiro-Wilk Test, the data followed a normal distribution (W=0.99). The reference interval of children’s serum 25(OH)D concentrations by LC-MS/MS was 11.35–44.57 ng/mL. In measuring 25(OH)D concentration of children, CLIA represented higher levels than LC-MS/MS. The two methods were consistent in diagnosing vitamin D deficiency. The reference interval of children’s serum 25(OH)D concentrations by LC-MS/MS was 11.35–44.57 ng/mL in our area in summer.
- 著者
- Jing Yang Jing Zhong Ling-Zhi Zhou Tao Hong Xin-Hua Xiao Ge-Bo Wen
- 出版者
- 一般社団法人 日本内科学会
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.51, no.16, pp.2189-2192, 2012 (Released:2012-08-15)
- 参考文献数
- 25
- 被引用文献数
- 10 23
Agranulocytosis is a rare adverse effect of methimazole. The usual duration of treatment prior to the onset of agranulocytosis is approximately 1 to 4 months, and can be as long as 1 year. Agranulocytosis together with hepatotoxicity is an extremely rare idiosyncratic side effect of methimazole treatment. We present an unprecedented case of a Grave's disease patient who showed a strong reaction to methimazole with obvious agranulocytosis and hepatotoxicity which developed only six days after administration. This case, along with a literature review, is offered with the aim to increase the awareness of physicians of sudden onset agranulocytosis and hepatotoxicity from methimazole.