著者
Satoshi Iwata Shinya Murata Shi Rong Han Akira Wakana Miyuki Sawata Yoshiyuki Tanaka
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2016.299, (Released:2016-12-22)
参考文献数
23
被引用文献数
6

A 9-valent human papillomavirus (HPV 6/11/16/18/31/33/45/52/58) virus-like particle (VLP) vaccine (9vHPV) has been proven highly efficacious in preventing anogenital disease related with vaccine HPV types in a pivotal Phase III study in women aged 16 to 26 years. We report here the results of an open-label phase III study conducted to bridge the findings in women age 16 to 26 years to Japanese girls aged 9 to 15 years. All subjects (n = 100) received a 3-dose regimen of 9vHPV vaccine at day 1, month 2 and month 6. Anti-HPV serologic assays were performed at day 1, month 7, month 12, month 24 and month 30. At month 7 (4 weeks after dose 3), 100% of subjects seroconverted for each vaccine HPV type. Increases in geometric mean titers of anti-HPV 6/11/16/18/31/33/45/52/58 in girls were similar to those in Japanese women aged 16 to 26 years in the pivotal phase III study. Persistence of anti-HPV responses was observed through 2 years after dose 3. In addition, administration of 9vHPV vaccine was generally well tolerated in Japanese girls.
著者
Yoshikazu Iha Futoshi Higa Satoko Sunagawa Masamitsu Naka Haley L. Cash Kazuya Miyagi Shusaku Haranaga Masao Tateyama Tsukasa Uno Jiro Fujita
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.65, no.4, pp.295-300, 2012 (Released:2012-09-21)
参考文献数
27
被引用文献数
8 9

Climatic conditions may have affected the incidence of influenza during the pandemic of 2009 as well as at other times. This study evaluated the effects of climatic conditions on influenza incidence in Okinawa, a subtropical region in Japan, during the 2009 pandemic using surveillance data from rapid antigen test (RAT) results. Weekly RAT results performed in four acute care hospitals in the Naha region of the Okinawa Islands from January 2007 to July 2011 were anonymously collected for surveillance of regional influenza prevalence. Intense epidemic peaks were noted in August 2009 and December 2009–January 2010 during the influenza pandemic of 2009. RAT positivity rates were lower during the pandemic period than during the pre- and post-pandemic periods. Lower ambient temperature was associated with higher influenza incidence during pre- and post-pandemic periods but not during the pandemic of 2009. Lower relative humidity was associated with higher influenza incidence during the pandemic as well as during the other two periods. The association of climatic conditions and influenza incidence was less prominent during the pandemic of 2009 than during pre- and post-pandemic periods.
著者
Kenichi Komabayashi Junji Seto Shizuka Tanaka Yu Suzuki Tatsuya Ikeda Noriko Onuki Keiko Yamada Tadayuki Ahiko Hitoshi Ishikawa Katsumi Mizuta
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.71, no.6, pp.413-418, 2018-11-30 (Released:2018-11-22)
参考文献数
26
被引用文献数
1 19

The incidence of modified measles (M-Me), characterized by milder symptoms than those of typical measles (T-Me), has been increasing in Japan. However, the outbreak dominated by M-Me cases has not been thoroughly investigated worldwide. The largest importation-related outbreak of measles with genotype D8 occurred in Yamagata Prefecture, Japan, from March to April 2017. This phenomenon was observed after Japan had achieved measles elimination in 2015. We confirmed 60 cases by detecting the genome of the measles virus (MeV). Among the cases, 38 were M-Me and 22 were T-Me. Thirty-nine (65.0%) patients were 20–39 years of age. Three out of 7 primary cases produced 50 transmissions, of which each patient caused 9–25 transmissions. These patients were 22–31 years old and were not vaccinated. Moreover, they developed T-Me and kept contact with the public during their symptomatic periods. Considering that M-Me is generally caused by vaccine failure, some individuals in Japan may have insufficient immunity for MeV. Accordingly, additional doses of measles vaccine may be necessary in preventing measles importation and endemicity among individuals aged 20–39 years. Furthermore, to accurately and promptly diagnose individuals with measles, particularly those who can be considered as primary cases, efforts must be exerted to detect all measles cases using epidemiological and genetic approaches in countries where measles elimination had been achieved.
著者
Tomoko Sakihama Yasuharu Tokuda
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2015.489, (Released:2016-02-19)
参考文献数
26
被引用文献数
7

The risk factors are unclear for peripheral venous catheter-associated bloodstream infections (PVCBSI) by Bacillus cereus (B. cereus). Thus, we aimed to examine the risk factors in patients with B. cereus PVCBSI by conducting a 2-year case-control study in a large teaching hospital. We analyzed all adult cases of B. cereus PVCBSI (37 patients) and 180 controls, who were randomly selected from among patients who had a PVC in place for 2 days or longer. Multivariate analysis using the conditional logistic regression model indicated that independent risk factors were use of a peripheral parenteral nutrition(PPN) solution with adjusted odds ratio (OR) of 88.7 (95% confidence interval [CI], 17.4-451.9), and steroid therapy [adjusted OR, 5.7 (95% CI, 1.3-24.4)]. In conclusion, use of PPN solutions or steroids was independent risk factors for B. cereus PVCBSI. Appropriate use of PPN solutions may help prevent B. cereus PVCBSI. Prospective studies are needed to confirm these results.
著者
Satoshi Iwata Shinya Murata Shi Rong Han Akira Wakana Miyuki Sawata Yoshiyuki Tanaka
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.70, no.4, pp.368-373, 2017 (Released:2017-07-24)
参考文献数
23
被引用文献数
3 6

A 9-valent human papillomavirus (HPV 6/11/16/18/31/33/45/52/58) virus-like particle vaccine (9vHPV) has been proven highly efficacious in preventing anogenital diseases related to HPV, in a pivotal phase III study for women aged 16-26 years. Here, we report the results of an open-label phase III study conducted to bridge the gap between the findings in women aged 16-26 years and Japanese girls aged 9-15 years. All subjects (n = 100) received a 3-dose regimen of 9vHPV vaccine on day 1 and at months 2 and 6. Anti-HPV serological assays were performed on day 1 and at months 7, 12, 24, and 30. At month 7 (4 weeks after the third dose), 100% of the subjects exhibited seroconversion for each type of HPV. Increases in geometric mean of the titers for anti-HPV 6/11/16/18/31/33/45/52/58 in the subjects were similar to those in Japanese women aged 16-26 years in a previous phase III study. Persistence of the anti-HPV response was observed for 2 years after administration of the third dose. In addition, administration of the 9vHPV vaccine was generally well-tolerated in Japanese girls.
著者
Shinya Murata Yuzuru Takeuchi Kou Yamanaka Jun Hayakawa Masashige Yoshida Ruriko Yokokawa Akira Wakana Miyuki Sawata Yoshiyuki Tanaka
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.72, no.5, pp.299-305, 2019 (Released:2019-09-19)
参考文献数
30
被引用文献数
2

Human papillomavirus (HPV)-associated disease is common among men with HPV infection. A quadrivalent HPV (qHPV) vaccine has demonstrated 85.9% efficacy against HPV6/11/16/18-related, persistent (≥ 6 month) infection in a study of Japanese men aged 16–26 years old. Here, we report the results of an open-label study of the immunogenicity and tolerability of the qHPV vaccine (NCT02576054), conducted to bridge findings from Japanese men to Japanese boys aged 9–15 years old. A total of 100 boys completed a three-vaccination regimen (Day 1, and Months 2 and 6), and 99 boys were included in the primary analysis population. The rate of seroconversion at one month after vaccine Dose 3 (Month 7) was high for each type of HPV (anti-HPV6/11/16/18 seroconversion rates [95% CI]: 94.9% [85.5%, 98.3%], 99.0% [94.4%, 100.0%], 99.0% [94.5%, 100.0%], and 99.0% [94.4%, 100.0%], respectively). Moreover, anti-HPV6/11/16/18 geometric mean titers were 482.9 mMU/mL, 1052.8 mMU/mL, 3878.3 mMU/mL, and 1114.5 mMU/mL, respectively. Immune responses to the qHPV vaccine were non-inferior among Japanese boys included in the current study and compared with young Japanese men from a separate study. Injection-site reactions were the most common adverse events, and administration of the vaccine was well tolerated in Japanese boys.
著者
Kisei Minami Ryu Yasuda Runa Terakawa Yumi Koike Koichi Takeuchi Tsukasa Higuchi Ayaka Horiuchi Noriko Kubota Eiko Hidaka Yoshiyuki Kawakami
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.70, no.2, pp.192-194, 2017 (Released:2017-03-24)
参考文献数
9
被引用文献数
2

In the spring of 2015, we experienced a cluster of 4 sporadic cases of yersiniosis in children in Nagano prefecture, a rural area of Japan. Two patients developed appendicitis-like episodes; one had acute gastroenteritis, and the other had bacteremia associated with liver abscess. The causative agent of these infections was Yersinia enterocolitica serogroup O:8. None of the patients had an underlying illness, and all have recovered completely. The patients were neither socially nor geographically related to each other. These 4 consecutive cases suggest that Y. enterocolitica O:8 has spread substantially in the middle part of Japan, and that this virulent strain might be more common than previously reported in our country.
著者
Alfonsus Adrian Hadikusumo Takako Utsumi Mochamad Amin Siti Qamariyah Khairunisa Anittaqwa Istimagfirah Rury Mega Wahyuni Maria Inge Lusida Soetjipto Edhi Rianto Juniastuti Yoshitake Hayashi
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.69, no.6, pp.493-499, 2016 (Released:2016-11-22)
参考文献数
47
被引用文献数
1

Transgender people are at a high risk for sexually transmitted viruses such as hepatitis B virus (HBV) and human immunodeficiency virus (HIV). Moreover, Indonesia has a moderate-to-high rate of HBV infection and rapid epidemic growth of HIV infection; hepatitis C virus (HCV) infection can co-occur with HBV and HIV infections. In this study, 10 of 107 individuals (9.3%) were positive for HBV surface antigen (HBsAg) and/or HBV DNA, whereas 19 of 101 individuals (18.8%) with negative results for HBsAg were positive for HBV core antibody (anti-HBc). Seven of the 107 individuals (6.5%) were anti-HCV positive, and 16 of the 100 tested samples (16.0%) were HIV positive. Genotype and subtype analyses of all 10 HBV DNA (6 HBsAg positive and 4 anti-HBc positive) strains showed that 3 were of the HBV genotype/HBsAg subtype C/adrq+, one was of C/adw2, and 5 were of B/adw2. The HCV subtype distribution showed that 33.3% were of HCV-1b, and 66.7% were of HCV-3k (n = 6). These distributions differed from those found in the general population of Surabaya, Indonesia. Interestingly, HIV subtype analysis showed a high prevalence of HIV, with possible recombinants of CRF01_AE and subtype B.
著者
Rafael Alves Guimarães Roselma Lucchese Inaina Lara Fernandes Ivânia Vera Aurélio Goulart Rodovalho Vanessa Alves Guimarães Gracielle Cristina Silva Rodrigo Lopes de Felipe Paulo Alexandre de Castro Priscilla Martins Ferreira
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2015.490, (Released:2016-06-30)
参考文献数
51
被引用文献数
2

Objective: to estimate the prevalence and factors associated with lifetime HIV testing in non-injection drug users (NIDU). Methods: cross-sectional study was conducted with 323 individuals in clinics for chemical dependency of the state of Goiás, Central-West region of Brazil. Logistic regression analysis was used to identify factors associated with lifetime HIV testing. Results: The frequency of HIV testing was 48.9% (95% CI: 43.5-54.3%). HIV testing was associated with age, female gender, crack use, history of sexually transmitted infections, knowing people living with HIV/AIDS and/or someone who had died from AIDS, and having received some instruction on HIV/AIDS prevention methods. It was found that only 26.6% reported having access to the HIV rapid test. Conclusion: The determinants for HIV testing must be taken into account when planning prevention and programming strategies, including the widening of testing coverage among NIDU, educational health actions, links between sexually transmitted infections prevention services and addiction treatment services and the use of rapid tests to help people that are in contact with the virus learn about their HIV status, enter treatment, and improve their quality of life.
著者
Fujio Kakuya Hitoshi Okubo Hiroaki Fujiyasu Iori Wakabayashi Masayo Syouji Takahiro Kinebuchi
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2020.181, (Released:2020-05-29)
参考文献数
15
被引用文献数
1

Coronavirus disease 2019 (COVID-19) is a severe infectious disease of the respiratory tract caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2, and has a high mortality rate. The disease emerged from Wuhan, China, in late 2019, and spread to Japan, including Hokkaido, in January 2020. In February 2020, three children were diagnosed with COVID-19 in Furano, Hokkaido, Japan. During this period, influenza and human metapneumovirus infections were prevalent among children in the Furano region. Two of the three cases experienced co-infection with other respiratory viruses, including influenza virus A or human metapneumovirus. To the authors’ knowledge, the cases described in the present report were the first pediatric patients with COVID-19 in Japan. In children with COVID-19, the possibility of co-infection with other respiratory pathogens should be considered.
著者
Alfonsus Adrian Hadikusumo Takako Utsumi Mochamad Amin Siti Qamariyah Khairunisa Anittaqwa Istimagfirah Rury Mega Wahyuni Maria Inge Lusida Soetjipto Edhi Rianto Juniastuti Yoshitake Hayashi
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2015.384, (Released:2016-03-18)
参考文献数
47
被引用文献数
1

Transgender people are at high risk of sexually transmitted viruses such as hepatitis B virus (HBV) and human immunodeficiency virus (HIV). Moreover, Indonesia has a moderate to high rate of HBV infection and a rapid epidemic growth of HIV. Because hepatitis C virus (HCV) can co-occur with HBV and HIV, it was also evaluated in this study. Ten of 107 individuals (9.3%) were Hepatitis B surface antigen (HBsAg) positive and/or HBV DNA positive, whereas nineteen of 101 individuals (18.8%) with negative HBsAg were Hepatitis B core antibody (anti-HBc)-positive. Seven of 107 individuals (6.5%) were anti-HCV positive, and sixteen of 100 tested samples (16%) were HIV positive. Genotype and subtype analyses of all ten HBV DNA (six HBsAg positive and four anti-HBc positive) strains showed that three were HBV genotype/HBsAg subtype C/adrq+, one was C/adw2, and five were B/adw2. The HCV subtype distribution showed that 33.3% were HCV-1b, and 66.7% were HCV-3k (n=6). These distributions differed from those found in the general population of Surabaya, Indonesia. The HIV subtype analysis showed that, interestingly, a high prevalence of HIV, with possible recombinants of CRF01_AE and subtype B, were found.
著者
Li Shen Xiaoxia Liu Geng Feng Fu Shixuan Hao Minghui Zhang Ting Wang Jing Yang Xiao Wu Lingxiang Mao
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2015.464, (Released:2016-06-30)
参考文献数
27
被引用文献数
1 5

To investigate the epidemic of HIV, HCV and syphilis, HIV-1 subtype among men who have sex with men (MSM) and to measure factors that correlated with sexual transmitted infections (STIs), a cross-sectional survey was conducted among 657 MSM in Zhenjiang, Jiangsu, during 2012-2013. Social-demographic characterization and risky behaviors were collected and blood samples were obtained. In this survey, the prevalence of STIs of HIV (5.3%), HCV (0.6%) and syphilis (19.2%) were measured. Of 35 HIV-infected MSM, 1 (0.2%) and 17 (2.6%) were co-infected with HCV and syphilis. Among 33 samples with available HIV-1 genomic fragments sequences, 6.1% B, 72.7% CRF01_AE and 21.2% CRF07_BC were indentified. Multivariate logistic regression analysis showed that age>30 years (OR 2.002; 95% CI 1.144 to 3.502) and having had STIs symptoms in the past year (OR 11.673; 95% CI 3.092 to 44.078) were positively correlated with STIs positive, while consistently use condom when have sex with male partners (OR 0.621; 95% CI 0.408 to 0.945) was significantly associated with a low STIs rate. The worsening epidemic of HIV, HCV and syphilis, complex subtypes of HIV-1 and risk factors suggest that effective intervention strategies should be strengthened for MSM in Zhenjiang, Jiangsu.
著者
Hiroyuki Wakiguchi Yasuhiro Okamoto Manaka Matsunaga Yuichi Kodama Akinori Miyazono Shunji Seki Naohiro Ikeda Yoshifumi Kawano
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2015.362, (Released:2015-11-13)
参考文献数
10
被引用文献数
2

Cat scratch disease (CSD) is an infectious disease caused by Bartonella henselae. Atypical clinical presentations of CSD include prolonged fever and multiple hepatosplenic lesions, although these are rare. Furthermore, multiple renal lesions are extremely rare in CSD. The patient was an 11-year-old Japanese girl who had a prolonged fever of unknown cause after being scratched and bitten by a kitten. Abdominal computed tomography (CT) revealed multiple small, round hypodense lesions in both kidneys and in the spleen. Based on her history and the results of CT, a diagnosis of CSD was made; the diagnosis was confirmed with serological tests, which indicated antibodies against Bartonella henselae. After treatment with azithromycin, her fever immediately improved. Careful history taking and imaging are essential for the diagnosis of atypical CSD. In CT images, not only hepatosplenic lesions but also renal lesions are important features indicative of a diagnosis of atypical CSD. Subsequently, a diagnosis of CSD can be confirmed with specific serological tests. To the best of our knowledge, this is the first reported Japanese case of multiple renal and splenic lesions in a patient with CSD. Although atypical CSD is difficult to diagnose, an early diagnosis is important to prevent invasive examinations.
著者
Malay Kumar Saha Tanmay Mahapatra Subrata Biswas Piyali Ghosh Sanchita Mahapatra Aloke Kumar Deb Kshitiz Diwan
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2013.068, (Released:2014-11-25)
参考文献数
25
被引用文献数
1 2

Men having sex with men (MSM) in India are mostly hidden due to stigma and discrimination and are at higher risk of HIV acquisition. HIV Sentinel Surveillance (HSS) pointed rising HIV burden for Chhattisgarh, an important central Indian province, with the distinction of highest HIV prevalence among MSM in India and, therefore, warrants special attention to study the role of MSM in HIV epidemic. Cross-sectional analysis of latest (2010-11) HSS data for 227 MSM in Chhattisgarh revealed 14.98% HIV sero-positivity. Older age, unemployment and receiving money for sex with a man were associated with higher HIV risk. Participants were mostly young (mean age 26 years), school-level educated (51.98%), urban residents (99.56%), doing service (46.26%), not involved in heterosexual activities (97.36%) or paid sex (68.72%). None of the participants reported injecting drug use and almost all of them (98.68%) were Kothis. Some of the observed associations lacked statistical power due to sparse data in this initial surveillance among MSM in Chhattisgarh indicating the need for studies involving larger population to understand the role of MSM in the dynamics of HIV epidemic in this state for planning appropriate interventions as the epidemic probably being concentrated among MSM in Chhattisgarh.