著者
Satoshi Iwata Shinya Murata Shi Rong Han Akira Wakana Miyuki Sawata Yoshiyuki Tanaka
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2016.299, (Released:2016-12-22)
参考文献数
23
被引用文献数
4

A 9-valent human papillomavirus (HPV 6/11/16/18/31/33/45/52/58) virus-like particle (VLP) vaccine (9vHPV) has been proven highly efficacious in preventing anogenital disease related with vaccine HPV types in a pivotal Phase III study in women aged 16 to 26 years. We report here the results of an open-label phase III study conducted to bridge the findings in women age 16 to 26 years to Japanese girls aged 9 to 15 years. All subjects (n = 100) received a 3-dose regimen of 9vHPV vaccine at day 1, month 2 and month 6. Anti-HPV serologic assays were performed at day 1, month 7, month 12, month 24 and month 30. At month 7 (4 weeks after dose 3), 100% of subjects seroconverted for each vaccine HPV type. Increases in geometric mean titers of anti-HPV 6/11/16/18/31/33/45/52/58 in girls were similar to those in Japanese women aged 16 to 26 years in the pivotal phase III study. Persistence of anti-HPV responses was observed through 2 years after dose 3. In addition, administration of 9vHPV vaccine was generally well tolerated in Japanese girls.
著者
Satoshi Iwata Shinya Murata Shi Rong Han Akira Wakana Miyuki Sawata Yoshiyuki Tanaka
出版者
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.70, no.4, pp.368-373, 2017 (Released:2017-07-24)
参考文献数
23
被引用文献数
3 4

A 9-valent human papillomavirus (HPV 6/11/16/18/31/33/45/52/58) virus-like particle vaccine (9vHPV) has been proven highly efficacious in preventing anogenital diseases related to HPV, in a pivotal phase III study for women aged 16-26 years. Here, we report the results of an open-label phase III study conducted to bridge the gap between the findings in women aged 16-26 years and Japanese girls aged 9-15 years. All subjects (n = 100) received a 3-dose regimen of 9vHPV vaccine on day 1 and at months 2 and 6. Anti-HPV serological assays were performed on day 1 and at months 7, 12, 24, and 30. At month 7 (4 weeks after the third dose), 100% of the subjects exhibited seroconversion for each type of HPV. Increases in geometric mean of the titers for anti-HPV 6/11/16/18/31/33/45/52/58 in the subjects were similar to those in Japanese women aged 16-26 years in a previous phase III study. Persistence of the anti-HPV response was observed for 2 years after administration of the third dose. In addition, administration of the 9vHPV vaccine was generally well-tolerated in Japanese girls.
著者
Kisei Minami Ryu Yasuda Runa Terakawa Yumi Koike Koichi Takeuchi Tsukasa Higuchi Ayaka Horiuchi Noriko Kubota Eiko Hidaka Yoshiyuki Kawakami
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.70, no.2, pp.192-194, 2017 (Released:2017-03-24)
参考文献数
9
被引用文献数
1

In the spring of 2015, we experienced a cluster of 4 sporadic cases of yersiniosis in children in Nagano prefecture, a rural area of Japan. Two patients developed appendicitis-like episodes; one had acute gastroenteritis, and the other had bacteremia associated with liver abscess. The causative agent of these infections was Yersinia enterocolitica serogroup O:8. None of the patients had an underlying illness, and all have recovered completely. The patients were neither socially nor geographically related to each other. These 4 consecutive cases suggest that Y. enterocolitica O:8 has spread substantially in the middle part of Japan, and that this virulent strain might be more common than previously reported in our country.
著者
Tomoko Sakihama Yasuharu Tokuda
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2015.489, (Released:2016-02-19)
参考文献数
26
被引用文献数
2

The risk factors are unclear for peripheral venous catheter-associated bloodstream infections (PVCBSI) by Bacillus cereus (B. cereus). Thus, we aimed to examine the risk factors in patients with B. cereus PVCBSI by conducting a 2-year case-control study in a large teaching hospital. We analyzed all adult cases of B. cereus PVCBSI (37 patients) and 180 controls, who were randomly selected from among patients who had a PVC in place for 2 days or longer. Multivariate analysis using the conditional logistic regression model indicated that independent risk factors were use of a peripheral parenteral nutrition(PPN) solution with adjusted odds ratio (OR) of 88.7 (95% confidence interval [CI], 17.4-451.9), and steroid therapy [adjusted OR, 5.7 (95% CI, 1.3-24.4)]. In conclusion, use of PPN solutions or steroids was independent risk factors for B. cereus PVCBSI. Appropriate use of PPN solutions may help prevent B. cereus PVCBSI. Prospective studies are needed to confirm these results.
著者
Alfonsus Adrian Hadikusumo Takako Utsumi Mochamad Amin Siti Qamariyah Khairunisa Anittaqwa Istimagfirah Rury Mega Wahyuni Maria Inge Lusida Soetjipto Edhi Rianto Juniastuti Yoshitake Hayashi
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.69, no.6, pp.493-499, 2016 (Released:2016-11-22)
参考文献数
47
被引用文献数
1

Transgender people are at a high risk for sexually transmitted viruses such as hepatitis B virus (HBV) and human immunodeficiency virus (HIV). Moreover, Indonesia has a moderate-to-high rate of HBV infection and rapid epidemic growth of HIV infection; hepatitis C virus (HCV) infection can co-occur with HBV and HIV infections. In this study, 10 of 107 individuals (9.3%) were positive for HBV surface antigen (HBsAg) and/or HBV DNA, whereas 19 of 101 individuals (18.8%) with negative results for HBsAg were positive for HBV core antibody (anti-HBc). Seven of the 107 individuals (6.5%) were anti-HCV positive, and 16 of the 100 tested samples (16.0%) were HIV positive. Genotype and subtype analyses of all 10 HBV DNA (6 HBsAg positive and 4 anti-HBc positive) strains showed that 3 were of the HBV genotype/HBsAg subtype C/adrq+, one was of C/adw2, and 5 were of B/adw2. The HCV subtype distribution showed that 33.3% were of HCV-1b, and 66.7% were of HCV-3k (n = 6). These distributions differed from those found in the general population of Surabaya, Indonesia. Interestingly, HIV subtype analysis showed a high prevalence of HIV, with possible recombinants of CRF01_AE and subtype B.
著者
Rafael Alves Guimarães Roselma Lucchese Inaina Lara Fernandes Ivânia Vera Aurélio Goulart Rodovalho Vanessa Alves Guimarães Gracielle Cristina Silva Rodrigo Lopes de Felipe Paulo Alexandre de Castro Priscilla Martins Ferreira
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2015.490, (Released:2016-06-30)
参考文献数
51

Objective: to estimate the prevalence and factors associated with lifetime HIV testing in non-injection drug users (NIDU). Methods: cross-sectional study was conducted with 323 individuals in clinics for chemical dependency of the state of Goiás, Central-West region of Brazil. Logistic regression analysis was used to identify factors associated with lifetime HIV testing. Results: The frequency of HIV testing was 48.9% (95% CI: 43.5-54.3%). HIV testing was associated with age, female gender, crack use, history of sexually transmitted infections, knowing people living with HIV/AIDS and/or someone who had died from AIDS, and having received some instruction on HIV/AIDS prevention methods. It was found that only 26.6% reported having access to the HIV rapid test. Conclusion: The determinants for HIV testing must be taken into account when planning prevention and programming strategies, including the widening of testing coverage among NIDU, educational health actions, links between sexually transmitted infections prevention services and addiction treatment services and the use of rapid tests to help people that are in contact with the virus learn about their HIV status, enter treatment, and improve their quality of life.
著者
Alfonsus Adrian Hadikusumo Takako Utsumi Mochamad Amin Siti Qamariyah Khairunisa Anittaqwa Istimagfirah Rury Mega Wahyuni Maria Inge Lusida Soetjipto Edhi Rianto Juniastuti Yoshitake Hayashi
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2015.384, (Released:2016-03-18)
参考文献数
47
被引用文献数
1

Transgender people are at high risk of sexually transmitted viruses such as hepatitis B virus (HBV) and human immunodeficiency virus (HIV). Moreover, Indonesia has a moderate to high rate of HBV infection and a rapid epidemic growth of HIV. Because hepatitis C virus (HCV) can co-occur with HBV and HIV, it was also evaluated in this study. Ten of 107 individuals (9.3%) were Hepatitis B surface antigen (HBsAg) positive and/or HBV DNA positive, whereas nineteen of 101 individuals (18.8%) with negative HBsAg were Hepatitis B core antibody (anti-HBc)-positive. Seven of 107 individuals (6.5%) were anti-HCV positive, and sixteen of 100 tested samples (16%) were HIV positive. Genotype and subtype analyses of all ten HBV DNA (six HBsAg positive and four anti-HBc positive) strains showed that three were HBV genotype/HBsAg subtype C/adrq+, one was C/adw2, and five were B/adw2. The HCV subtype distribution showed that 33.3% were HCV-1b, and 66.7% were HCV-3k (n=6). These distributions differed from those found in the general population of Surabaya, Indonesia. The HIV subtype analysis showed that, interestingly, a high prevalence of HIV, with possible recombinants of CRF01_AE and subtype B, were found.
著者
Li Shen Xiaoxia Liu Geng Feng Fu Shixuan Hao Minghui Zhang Ting Wang Jing Yang Xiao Wu Lingxiang Mao
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2015.464, (Released:2016-06-30)
参考文献数
27
被引用文献数
1 1

To investigate the epidemic of HIV, HCV and syphilis, HIV-1 subtype among men who have sex with men (MSM) and to measure factors that correlated with sexual transmitted infections (STIs), a cross-sectional survey was conducted among 657 MSM in Zhenjiang, Jiangsu, during 2012-2013. Social-demographic characterization and risky behaviors were collected and blood samples were obtained. In this survey, the prevalence of STIs of HIV (5.3%), HCV (0.6%) and syphilis (19.2%) were measured. Of 35 HIV-infected MSM, 1 (0.2%) and 17 (2.6%) were co-infected with HCV and syphilis. Among 33 samples with available HIV-1 genomic fragments sequences, 6.1% B, 72.7% CRF01_AE and 21.2% CRF07_BC were indentified. Multivariate logistic regression analysis showed that age>30 years (OR 2.002; 95% CI 1.144 to 3.502) and having had STIs symptoms in the past year (OR 11.673; 95% CI 3.092 to 44.078) were positively correlated with STIs positive, while consistently use condom when have sex with male partners (OR 0.621; 95% CI 0.408 to 0.945) was significantly associated with a low STIs rate. The worsening epidemic of HIV, HCV and syphilis, complex subtypes of HIV-1 and risk factors suggest that effective intervention strategies should be strengthened for MSM in Zhenjiang, Jiangsu.
著者
Hiroyuki Wakiguchi Yasuhiro Okamoto Manaka Matsunaga Yuichi Kodama Akinori Miyazono Shunji Seki Naohiro Ikeda Yoshifumi Kawano
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2015.362, (Released:2015-11-13)
参考文献数
10
被引用文献数
1

Cat scratch disease (CSD) is an infectious disease caused by Bartonella henselae. Atypical clinical presentations of CSD include prolonged fever and multiple hepatosplenic lesions, although these are rare. Furthermore, multiple renal lesions are extremely rare in CSD. The patient was an 11-year-old Japanese girl who had a prolonged fever of unknown cause after being scratched and bitten by a kitten. Abdominal computed tomography (CT) revealed multiple small, round hypodense lesions in both kidneys and in the spleen. Based on her history and the results of CT, a diagnosis of CSD was made; the diagnosis was confirmed with serological tests, which indicated antibodies against Bartonella henselae. After treatment with azithromycin, her fever immediately improved. Careful history taking and imaging are essential for the diagnosis of atypical CSD. In CT images, not only hepatosplenic lesions but also renal lesions are important features indicative of a diagnosis of atypical CSD. Subsequently, a diagnosis of CSD can be confirmed with specific serological tests. To the best of our knowledge, this is the first reported Japanese case of multiple renal and splenic lesions in a patient with CSD. Although atypical CSD is difficult to diagnose, an early diagnosis is important to prevent invasive examinations.
著者
Malay Kumar Saha Tanmay Mahapatra Subrata Biswas Piyali Ghosh Sanchita Mahapatra Aloke Kumar Deb Kshitiz Diwan
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2013.068, (Released:2014-11-25)
参考文献数
25
被引用文献数
1 1

Men having sex with men (MSM) in India are mostly hidden due to stigma and discrimination and are at higher risk of HIV acquisition. HIV Sentinel Surveillance (HSS) pointed rising HIV burden for Chhattisgarh, an important central Indian province, with the distinction of highest HIV prevalence among MSM in India and, therefore, warrants special attention to study the role of MSM in HIV epidemic. Cross-sectional analysis of latest (2010-11) HSS data for 227 MSM in Chhattisgarh revealed 14.98% HIV sero-positivity. Older age, unemployment and receiving money for sex with a man were associated with higher HIV risk. Participants were mostly young (mean age 26 years), school-level educated (51.98%), urban residents (99.56%), doing service (46.26%), not involved in heterosexual activities (97.36%) or paid sex (68.72%). None of the participants reported injecting drug use and almost all of them (98.68%) were Kothis. Some of the observed associations lacked statistical power due to sparse data in this initial surveillance among MSM in Chhattisgarh indicating the need for studies involving larger population to understand the role of MSM in the dynamics of HIV epidemic in this state for planning appropriate interventions as the epidemic probably being concentrated among MSM in Chhattisgarh.
著者
Thana Khawcharoenporn Benjawan Phetsuksiri Janisara Rudeeaneksin Sopa Srisungngam Anucha Apisarnthanarak
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2016.480, (Released:2017-03-28)
参考文献数
23
被引用文献数
1

Optimal testing strategy for diagnosing latent tuberculosis infection and guiding isoniazid preventive therapy (IPT) is uncertain among HIV-infected patients. A 4-year prospective study was conducted among Thai HIV-infected patients who underwent simultaneous tuberculin skin test (TST) and QuantiFERON®-TB Gold In-tube Test (QFT-IT) at care entry. Based on baseline test results, patients were categorized into 4 groups: 1) QFT-IT-positive, TST-reactive 2) QFT-IT-positive, TST-non-reactive 3) QFT-IT-negative, TST-reactive, or 4) QFT-IT-negative, TST-non-reactive. The QFT-IT-positive patients were offered 9-month IPT and underwent yearly QFT-IT. Among 150 enrolled patients, there were 8, 12, 16 and 114 patients in group 1, 2, 3 and 4, respectively. Sixteen of 19 QFT-IT-positive patients (84%) completed IPT. The incidence of tuberculosis was significantly higher in patients who declined IPT than those completing IPT (11.11 vs. 0 case/100 patient-year; P<0.001). Among the 16 patients completing IPT, 11 (69%) and 2 (12%) had QFT-IT reversion at 1 year and 2 years after IPT, respectively. The remaining 3/16 (19%) had no reversion and their baseline interferon-γ levels were all above 1.2 IU/ml. Initial QFT-IT-guided IPT was effective in preventing tuberculosis. Serial QFT-IT for evaluating IPT effectiveness had limitations given delayed and no reversion, especially in those with high baseline interferon-γ levels.
著者
Yoshiyuki Sugishita Takuya Yamagishi Yuzo Arima Narumi Hori Naomi Seki
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.69, no.2, pp.154-157, 2016 (Released:2016-03-23)
参考文献数
10
被引用文献数
1 4

The number of notified syphilis cases in Tokyo has more than doubled in recent years. The number of reported primary and secondary syphilis cases increased from 108 cases (0.8 per 100,000 population) in 2007 to 245 cases in 2013 (1.9 per 100,000 population). During this period, the majority of cases was male (905/1,024), and the recent increase among primary and secondary syphilis cases was attributed to the increase among males (90/108 [83%] cases in 2007 to 218/245 [89%] cases in 2013); men aged 20–49 years contributed most to the increase, with those aged 30–34 years having the highest notification rate in 2013. Male-to-male transmission was the primary route of infection reported, and men who have sex with men (MSM) accounted for nearly 80% of male cases in 2013. Syphilis appears to be reemerging in Tokyo, and reducing the risk of acquiring syphilis among MSM aged 20–49 years should be a public health priority in Tokyo.
著者
Minetaro Arita
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2016.356, (Released:2016-10-31)
参考文献数
100
被引用文献数
3

Since the start of Global Polio Eradication Initiative in 1988, poliomyelitis cases caused by wild poliovirus (PV) were drastically reduced to only 74 cases in 2 endemic countries in 2015. With established vaccine campaign, current limited PV transmission suggested the endgame of the polio eradication program. In the endgame, we have emerging challenges specific to the endgame; tight budget, switching of the vaccines, and changes in the biorisk management. To overcome these challenges, several projects of PV study attract attention in the eradication program. Some of these emerging challenges/projects of PV study might arise as critical issues in the other eradication programs of the infectious diseases. Here, I will review state of the art of PV study and challenges that confront the polio eradication program.
著者
Yoshiyuki Sugishita Takuya Yamagishi Yuzo Arima Narumi Hori Naomi Seki
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2015.312, (Released:2015-09-11)
参考文献数
10
被引用文献数
1 4

The number of notified syphilis cases in Tokyo has more than doubled in recent years. The number of reported primary and secondary syphilis cases increased from 108 cases (0.8 per 100,000 population) in 2007 to 245 cases in 2013 (1.9 per 100,000 population). During this period, the majority of cases was male (905/1,024), and the recent increase among primary and secondary syphilis cases was attributed to the increase among males (90/108 [83%] cases in 2007 to 218/245 [89%] cases in 2013); men aged 20-49 years contributed most to the increase, with those aged 30-34 years having the highest rate in 2013. Male-to-male transmission was the primary route of infection reported, and men who have sex with men (MSM) accounted for nearly 80% of male cases in 2013. Syphilis appears to be reemerging in Tokyo, and reducing the risk of acquiring syphilis among MSM aged 20-49 years should be a public health priority in Tokyo.
著者
Panita Pathipvanich Naho Tsuchiya Archawin Rojanawiwat Wolf-Peter Schmidt Wattana Auwanit Pathom Sawanpanyalert Koya Ariyoshi
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.66, no.5, pp.375-378, 2013 (Released:2013-09-19)
参考文献数
14
被引用文献数
3 4

We conducted a hospital-based descriptive study to describe the changing pattern of patient numbers, characteristics, and mortality rates among human immunodeficiency virus (HIV)-infected patients in northern Thailand over 15 years. The survival status on October 31, 2010 of all HIV-infected adults who attended an HIV center in a government hospital between 1995 and 2010 was ascertained. In total, 3,706 patients were registered, 2,118 (57.2%) of which were male. The survival status of 3,439 patients (92.9%) was available. In addition, 1,543 deaths were identified out of 12,858 person-year-observations (PYO) resulting in a mortality rate of 12.4 deaths/100 PYO (95% confidence interval [CI], 11.3–13.0). An initial decline in mortality rates was observed prior to 1999, probably because of an increase in the proportion of less symptomatic patients. After the introduction of the national highly active antiretroviral therapy (HAART) program, a profound decline in mortality rates was observed, reaching 2.0 deaths/100 PYO (95% CI, 1.4–2.9) in 2010. Simultaneously, the number of patients on follow-up increased by nearly fourfold. Although HAART has drastically improved the survival of HIV-infected patients, the number of patients receiving therapy at this HIV clinic has substantially increased. While referral of HIV patients to general physicians' care should be urged, we cannot overemphasize the importance of preventing new HIV infections.